« Previous
Next »
Biology of Blood and Marrow Transplantation
Volume 14, Issue 1
, Pages 67-74
, January 2008
Recipient NOD2/CARD15 Variants: A Novel Independent Risk Factor for the Development of Bronchiolitis Obliterans after Allogeneic Stem Cell Transplantation
References
- Specific immune responses against airway epithelial cells in a transgenic mouse trachea transplantation model for obliterative airway disease. Transplantation. 2003;76:1022–1028
- Immune mechanisms in the pathogenesis of bronchiolitis obliterans syndrome after lung transplantation. Pediatr Transplant. 2005;9:84–93
- Both donor and recipient NOD2/CARD15 mutations associate with transplant-related mortality and GvHD following allogeneic stem cell transplantation. Blood. 2004;104:889–894
- Effect of NOD2/CARD15 variants in T-cell–depleted allogeneic stem cell transplantation. Haematologica. 2006;91:1372–1376
- Lung epithelium as a sentinel and effector system in pneumonia–molecular mechanisms of pathogen recognition and signal transduction. Respir Res. 2006;7:97
- Pretransplant lung function, respiratory failure, and mortality after stem cell transplantation. Am J Respir Crit Care Med. 2005;172:384–390
- Measuring therapeutic response in chronic graft-versus-host disease: National Institute of Health Consensus Development Project on criteria for clinical trials in chronic graft-versus-host disease: IV. Response criteria working group report. Biol Blood Marrow Transplant. 2006;12:252–266
- Prevalence of CARD15/NOD2 mutations in Caucasian healthy people. Am J Gastroenterol. 2007;102:1259–1267
- Analysis of the CARD15 variants R702W, G908R and L1007fs in Italian IBD patients. Eur J Hum Genet. 2004;12:206–212
- CARD15 mutations in Dutch familial and sporadic inflammatory bowel disease and an overview of European studies. Eur J Gastroenterol Hepatol. 2007;19:449–459
- Risk factors for bronchiolitis obliterans in allogeneic hematopoietic stem-cell transplantation for leukemia. Chest. 2005;128:153–161
- Bronchiolitis obliterans in bone marrow transplantation and its relationship to chronic graft-versus-host disease and low serum IgG. Blood. 1988;72:621–627
- Incidence, outcome, and risk factors of late-onset noninfectious pulmonary complications after unrelated donor stem cell transplantation. Bone Marrow Transplant. 2004;33:751–758
- Late-onset noninfectious pulmonary complications after allogeneic bone marrow transplantation. Br J Haematol. 1998;100:680–687
- Bronchiolitis obliterans in chronic graft-versus-host disease: analysis of risk factors and treatment outcomes. Biol Blood Marrow Transplant. 2003;9:657–666
- Long-term follow-up of immunosuppressive treatment for obstructive airway disease after allogeneic bone marrow transplantation. Bone Marrow Transplant. 1997;20:403–408
- Airflow obstruction after myeloablative allogeneic hematopoietic stem cell transplantation. Am J Respir Crit Care Med. 2003;168:208–214
- Late pulmonary impairment following allogeneic bone marrow transplantation. Eur J Med Res. 1996;1:343–348
- Risk factors for air-flow obstruction in recipients of bone marrow transplants. Ann Intern Med. 1987;107:648–656
- Obstructive lung disease after allogeneic marrow transplantation: clinical presentation and course. Ann Intern Med. 1989;111:368–376
- Non-infectious lung complications are closely associated with chronic graft-versus-host disease: a single-center study of incidence, risk factors and outcome. Bone Marrow Transplant. 2000;25:1263–1268
- Bronchiolitis obliterans after bone marrow transplantation: the effect of preconditioning. Respiration. 1993;60:109–114
- Host recognition of bacterial muramyl dipeptide mediated through NOD2: implications for Crohn's disease. J Biol Chem. 2003;278:5509–5512
- . Nods: a family of cytosolic proteins that regulate the host response to pathogens. Curr Opin Microbiol. 2002;5:76–80
- Card15 gene overexpression in mononuclear and epithelial cells of the inflamed Crohn's disease colon. Gut. 2003;52:840–846
- CARD15/NOD2 functions as an antibacterial factor in human intestinal epithelial cells. Gastroenterology. 2003;124:993–1000
- Nucleotide-binding oligomerization domain proteins are innate immune receptors for internalized Streptococcus pneumoniae. J Biol Chem. 2004;279:36426–36432
- Various human epithelial cells express functional Toll-like receptors, NOD1 and NOD2 to produce anti-microbial peptides, but not proinflammatory cytokines. Mol Immunol. 2007;44(12):3100–3111
- TNF-alpha and IFN-gamma regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells. Gastroenterology. 2003;124:1001–1009
- Increased bronchoalveolar lavage human beta-defensin type 2 in bronchiolitis obliterans syndrome after lung transplantation. Transplantation. 2004;78:1222–1224
- Proteomic identification of human neutrophil alpha-defensins in chronic lung allograft rejection. Proteomics. 2005;5:1705–1713
- Transcript signatures of lymphocytic bronchitis in lung allograft biopsy specimens. J Heart Lung Transplant. 2005;24:1055–1066
- . NOD2/CARD15 and the Paneth cell: another piece in the genetic jigsaw of inflammatory bowel disease. Gut. 2003;52:1533–1535
- . NOD2 mutations and Crohn's disease: are Paneth cells and their antimicrobial peptides the link?. Gut. 2004;53:1558–1560
- NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression. Gut. 2004;53:1658–1664
- Defensin deficiency, intestinal microbes, and the clinical phenotypes of Crohn's disease. J Leukoc Biol. 2005;77:460–465
- Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science. 2005;307:731–734
- NOD2/CARD15 mediates induction of the antimicrobial peptide human beta-defensin-2. J Biol Chem. 2006;281:2005–2011
- . Paneth cells: leukocyte-like mediators of innate immunity in the intestine. J Leukoc Biol. 2006;80:500–508
- Airway goblet cells and respiratory epithelial injury in an animal model of obliterative airways disease (OAD). Am J Transplant. 2001;1:321–324
- Obliterative airway disease in rat tracheal allografts requires tumor necrosis factor alpha. Exp Mol Pathol. 2005;78:190–197
- Regulatory role of IL-10 in experimental obliterative bronchiolitis in rats. Exp Mol Pathol. 2002;73:164–170
- Integrity of airway epithelium is essential against obliterative airway disease in transplanted rat tracheas. J Heart Lung Transplant. 2005;24:882–890
- IFNγ differentially controls the development of idiopathic pneumonia syndrome and GVHD of the gastrointestinal tract. Blood. 2007;110:1064–1072
- Azithromycin in bronchiolitis obliterans complicating bone marrow transplantation: a preliminary study. Eur Respir J. 2005;25:490–493
- Genetic variation in bactericidal/permeability-increasing protein influences the risk of developing rapid airflow decline after hematopoietic cell transplantation. Blood. 2006;107:2200–2207
- NOD2 is a negative regulator of Toll-like receptor 2–mediated T helper type 1 responses. Nat Immunol. 2004;5:800–808
- Early-onset sarcoidosis and CARD15 mutations with constitutive nuclear factor-κB activation: common genetic etiology with Blau syndrome. Blood. 2005;105:1195–1197
- Interstitial pneumonitis in Blau syndrome with documented mutation in CARD15. Arthritis Rheum. 2007;56:1292–1294
Dr. Hildebrandt is a Max Eder Scholar of the Deutsche Krebshilfe eV and a Research Scholar of the European Hematology Association.
PII: S1083-8791(07)00464-8
doi: 10.1016/j.bbmt.2007.09.009
© 2008 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.
« Previous
Next »
Biology of Blood and Marrow Transplantation
Volume 14, Issue 1
, Pages 67-74
, January 2008
