Biology of Blood and Marrow Transplantation
Volume 14, Issue 1 , Pages 88-98 , January 2008

Once-Daily Intravenous Busulfan with Therapeutic Drug Monitoring Compared to Conventional Oral Busulfan Improves Survival and Engraftment in Children Undergoing Allogeneic Stem Cell Transplantation

  • Imke H. Bartelink

      Affiliations

    • Departments of Hematology, Immunology and Clinical Pharmacy, University Medical Center Utrecht, the Netherlands
    • Corresponding Author InformationCorrespondence and reprint requests: Imke Bartelink, University Medical Center, Department of Pharmacy, Room HP D00.218, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
    • ,
  • Robbert G.M. Bredius

      Affiliations

    • Departments of Hematology, Immunology and Clinical Pharmacy, Leiden University Medical Center, the Netherlands
    • ,
  • Tessa T. Ververs

      Affiliations

    • Departments of Hematology, Immunology and Clinical Pharmacy, University Medical Center Utrecht, the Netherlands
    • ,
  • Martine F. Raphael

      Affiliations

    • Departments of Hematology, Immunology and Clinical Pharmacy, University Medical Center Utrecht, the Netherlands
    • ,
  • Charlotte van Kesteren

      Affiliations

    • Departments of Hematology, Immunology and Clinical Pharmacy, University Medical Center Utrecht, the Netherlands
    • ,
  • Marc Bierings

      Affiliations

    • Departments of Hematology, Immunology and Clinical Pharmacy, University Medical Center Utrecht, the Netherlands
    • ,
  • Carin M.A. Rademaker

      Affiliations

    • Departments of Hematology, Immunology and Clinical Pharmacy, University Medical Center Utrecht, the Netherlands
    • ,
  • J. den Hartigh

      Affiliations

    • Departments of Hematology, Immunology and Clinical Pharmacy, Leiden University Medical Center, the Netherlands
    • ,
  • Cuno S.P.M. Uiterwaal

      Affiliations

    • Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, the Netherlands
    • ,
  • Juliette Zwaveling

      Affiliations

    • Departments of Hematology, Immunology and Clinical Pharmacy, Leiden University Medical Center, the Netherlands
    • ,
  • Jaap J. Boelens

      Affiliations

    • Departments of Hematology, Immunology and Clinical Pharmacy, University Medical Center Utrecht, the Netherlands

Received 23 July 2007 ,Accepted 24 September 2007.

  • Image Result

    Kaplan-Meier Curve of event free survival (a), survival (b) and graft failure (c) after HSCT with iv-targeted-Bu versus oral Bu.

    Kaplan-Meier Curve of event free survival (a), survival (b) and graft failure (c) after HSCT with iv-targeted-Bu versus oral Bu.

  • Image Result

    Example of blood concentrations in a patient.

    Example of blood concentrations in a patient.

PII: S1083-8791(07)00486-7

doi: 10.1016/j.bbmt.2007.09.015

Biology of Blood and Marrow Transplantation
Volume 14, Issue 1 , Pages 88-98 , January 2008

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