Biology of Blood and Marrow Transplantation
Volume 14, Issue 1 , Pages 7-9 , January 2008

Alemtuzumab-Induced Resolution of Refractory Cutaneous Chronic Graft-Versus-Host Disease

  • Guillermo J. Ruiz-Argüelles

      Affiliations

    • Centro de Hematología y Medicina Interna de Puebla, Puebla, Mexico
    • Corresponding Author InformationCorrespondence and reprint requests: Guillermo J. Ruiz-Argüelles, MD, FACP, FRCP (Glasg), Centro de Hematología y Medicina Interna de Puebla, 8B Sur 3710, 72530 Puebla, Mexico.
    • ,
  • Javier Gil-Beristain

      Affiliations

    • Centro Médico Anzures, Puebla, Mexico
    • ,
  • Mario Magaña

      Affiliations

    • Centro de Dermatología & Dermatopatología, Mexico City, Mexico
    • ,
  • Guillermo J. Ruiz-Delgado

      Affiliations

    • Hospital Universitario de Monterrey, Mexico City, Mexico

  • Image Result

    Skin biopsy obtained before treatment with alemtuzumab. Thinned and detached epidermis is apparent, with a hint of lichenoid arrangement of the lymphocytic infiltrate in the upper dermis.

    Skin biopsy obtained before treatment with alemtuzumab. Thinned and detached epidermis is apparent, with a hint of lichenoid arrangement of the lymphocytic infiltrate in the upper dermis.

  • Image Result

    A, Skin changes in the right lower limb of the patient prior to the treatment with alemtuzumab; extensive ulceration is obvious. B, The same region 6 months after the treatment.

    A, Skin changes in the right lower limb of the patient prior to the treatment with alemtuzumab; extensive ulceration is obvious. B, The same region 6 months after the treatment.

PII: S1083-8791(07)00488-0

doi: 10.1016/j.bbmt.2007.09.013

Biology of Blood and Marrow Transplantation
Volume 14, Issue 1 , Pages 7-9 , January 2008

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