Costs of Allogeneic Hematopoietic Cell Transplantation with High-Dose Regimens

Characteristics of costs during the first year. (A) Proportion of costs by phase after transplantation. Abbreviation: early phase, initial admission through 100 days after transplantation; later phase, from 101 days to 1 year (365 days) after transplantation. (B) Relationship between total costs and disease-free survival during the first year by each year of transplantation. Boxes indicate the median costs in 2004 dollars within the first year post-HDCT. Lines indicate the disease-free survival at 1 year. Numbers of patients in each transplant year are shown in the parentheses.

Relationship between costs and post-transplant events or death. (A) Costs and overall survival during the first year after transplantation by number of complications. Boxes indicate the estimated mean costs in 2004 dollars for the first year after transplantation, which were adjusted for patient and transplant characteristics and the 95% confidence interval were shown by the full range of upper and lower whiskers. Lines indicate the overall survival at 1 year. Late neutrophil recovery, veno-occlusive disease, idiopathic pneumonia/diffuse alveolar hemorrhage, severe infection, severe renal/bladder toxicity (≥grade 3), severe neurological toxicity (≥grade 3), severe cardiac toxicity (≥grade 3), grade II to IV acute GVHD, extensive chronic GVHD, relapse, and in-hospital death during the first year were considered. Numbers of patients with each number of complications are shown in the parentheses. (B) Costs during the first year after transplantation for deceased or surviving patients.