Biology of Blood and Marrow Transplantation
Volume 14, Issue 1 , Pages 1-6 , January 2008

State of the Art Review: HLA Matching and Outcome of Unrelated Donor Umbilical Cord Blood Transplants

  • Naynesh Kamani

      Affiliations

    • Children's National Medical Center, Washington, DC
    • ,
  • Stephen Spellman

      Affiliations

    • National Marrow Donor Program, Minneapolis, Minnesota
    • ,
  • Carolyn Katovich Hurley

      Affiliations

    • Department of Oncology, Georgetown University, Washington, DC
    • ,
  • Juliet N. Barker

      Affiliations

    • Memorial Sloan-Kettering Cancer Center, New York, New York
    • ,
  • Franklin O. Smith

      Affiliations

    • Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio
    • ,
  • Machteld Oudshoorn

      Affiliations

    • Europdonor Foundation, Leiden, The Netherlands
    • ,
  • Robert Bray

      Affiliations

    • Emory University School of Medicine, Atlanta, Georgia
    • ,
  • Anajane Smith

      Affiliations

    • Seattle Cancer Care Alliance, Seattle, Washington
    • ,
  • Thomas M. Williams

      Affiliations

    • University of New Mexico School of Medicine, Albuquerque, New Mexico
    • ,
  • Brent Logan

      Affiliations

    • CIBMTR Statistical Center, Medical College of Wisconsin, Milwaukee, Wisconsin
    • ,
  • Mary Eapen

      Affiliations

    • CIBMTR Statistical Center, Medical College of Wisconsin, Milwaukee, Wisconsin
    • ,
  • Claudio Anasetti

      Affiliations

    • H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida
    • ,
  • Michelle Setterholm

      Affiliations

    • National Marrow Donor Program, Minneapolis, Minnesota
    • ,
  • Dennis L. Confer

      Affiliations

    • National Marrow Donor Program, Minneapolis, Minnesota
    • Corresponding Author InformationCorrespondence and reprint requests: Dennis Confer, MD, National Marrow Donor Program, 3001 Broadway Street NE, Minneapolis, MN 55413.

Received 31 October 2007 ,Accepted 10 November 2007.

References 

  1. Kurtzberg J, Laughlin M, Graham ML, et al. Placental blood as a source of hematopoietic stem cells for transplantation into unrelated recipients. N Engl J Med. 1996;335:157–166
  2. Eapen M, Rubinstein P, Zhang MJ, et al. Outcomes of transplantation of unrelated donor umbilical cord blood and bone marrow in children with acute leukaemia: a comparison study. Lancet. 2007;369:1947–1954
  3. Rocha V, Cornish J, Sievers EL, et al. Comparison of outcomes of unrelated bone marrow and umbilical cord blood transplants in children with acute leukemia. Blood. 2001;97:2962–2971
  4. Laughlin MJ, Barker J, Bambach B, et al. Hematopoietic engraftment and survival in adult recipients of umbilical-cord blood from unrelated donors. N Engl J Med. 2001;344:1815–1822
  5. Laughlin MJ, Eapen M, Rubinstein P, et al. Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia. N Engl J Med. 2004;351:2265–2275
  6. Barker JN, Davies SM, DeFor T, Ramsay NK, Weisdorf DJ, Wagner JE. Survival after transplantation of unrelated donor umbilical cord blood is comparable to that of human leukocyte antigen-matched unrelated donor bone marrow: results of a matched-pair analysis. Blood. 2001;97:2957–2961
  7. Gluckman E, Rocha V. Donor selection for unrelated cord blood transplants. Curr Opin Immunol. 2006;18:565–570
  8. Hurley C, Baxter-Lowe LA, Davies S, et al. National Marrow Donor Program HLA matching guidelines for unrelated marrow transplants. Biol Blood Marrow Transplant. 2003;9:610–615
  9. Petersdorf EW, Longton GM, Anasetti C, et al. The significance of HLA-DRB1 matching on clinical outcome after HLA-A, B, DR identical unrelated donor marrow transplantation. Blood. 1995;86:1606–1613
  10. Flomenberg N, Baxter-Lowe LA, Confer D, et al. Impact of HLA class I and class II high-resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C mismatching is associated with a strong adverse effect on transplantation outcome. Blood. 2004;104:1923–1930
  11. Morishima Y, Sasazuki T, Inoki H, et al. The clinical significance of human leukocyte antigen (HLA) allele compatibility in patients receiving a marrow transplant from serologically HLA-A, HLA-B, and HLA-DR matched unrelated donors. Blood. 2002;99:4200–4206
  12. Petersdorf EW, Anasetti C, Martin PJ, et al. Limits of HLA mismatching in unrelated hematopoietic cell transplantation. Blood. 2004;104:2976–2980
  13. Lee SJ, Klein J, Haagenson M, et al. The contribution of high resolution donor-recipient HLA matching to the success of unrelated donor marrow transplantation. Prepublished online September 4, 2007; doi 10.1182/blood-2007-06-097386.
  14. Kernan NA, Carter SL, Wagner JE, et al. Umbilical cord blood transplantation in pediatric patients: results of the prospective, multi-institutional cord blood transplantation study (COBLT). Tandem BMT Meetings Abstract. 2006;
  15. Kogler G, Enczmann J, Rocha V, Gluckman E, Wernet P. High-resolution HLA typing by sequencing for HLA-A, -B, -C, -DR, -DQ in 122 unrelated cord blood/patient pair transplants hardly improves long-term clinical outcome. Bone Marrow Transplant. 2005;36:1033–1041
  16. Ohnuma K, Isoyama K, Ikuta K, et al. The influence of HLA genotyping compatibility on clinical outcome after cord blood transplantation from unrelated donors. J Hematother Stem Cell Res. 2000;9:541–550
  17. Cornetta K, Laughlin M, Carter S, et al. Umbilical cord blood transplantation in adults: results of the prospective Cord Blood Transplantation (COBLT). Biol Blood Marrow Transplant. 2005;11:149–160
  18. Kurtzberg J, Carter SL, Wagner JE, et al. Results of the Cord Blood Transplantation Study (COBLT): clinical outcomes of unrelated donor umbilical cord blood transplantation in pediatric patients with leukemia. Submitted.
  19. Petersdorf EW, Longton GM, Anasetti C, et al. Definition of HLA-DQ as a transplantation antigen. Proc Natl Acad Sci USA. 1996;93:15358–15363
  20. Hurley CK, Fernandez-Vina M, Hildebrand WH, et al. A high degree of HLA diversity arises from limited allelic diversity: analysis of 1775 unrelated bone marrow transplant donor-recipient pairs. Hum Immunol. 2007;68:30–40
  21. Rocha V, Labopin M, Sanz G, et al. Acute Leukemia Working Party of European Blood and Marrow Transplant Group; Eurocord-Netcord Registry. Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia. N Engl J Med. 2004;351:2276–2285
  22. Rubinstein P, Carrier C, Scaradavou A, et al. Outcomes among 562 recipients of placental-blood transplants from unrelated donors. N Engl J Med. 1998;339:1565–1577
  23. Gluckman E, Rocha V, Boyer-Chammard A, et al. Outcome of cord-blood transplantation from related and unrelated donors. Eurocord Transplant Group and the European Blood and Marrow Transplantation Group. N Engl J Med. 1997;337:373–381
  24. Wagner JE, Rosenthal J, Sweetman R, et al. Successful transplantation of HLA-matched and HLA-mismatched umbilical cord blood from unrelated donors: analysis of engraftment and acute graft-versus-host disease. Blood. 1996;88:795–802
  25. Wagner JE, Barker JN, DeFor TE, et al. Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival. Blood. 2002;100:1611–1618
  26. Migliaccio AR, Adamson JW, Stevens CE, Dobrila NL, Carrier CM, Rubinstein P. Cell dose and speed of engraftment in placental/umbilical cord blood transplantation: graft progenitor cell content is a better predictor than nucleated cell quantity. Blood. 2000;96:2717–2722
  27. Gluckman E, Rocha V, Arcese W, et al. Factors associated with outcomes of unrelated cord blood transplant: guidelines for donor choice. Exp Hematol. 2004;32:397–407
  28. Gibbons R. Analysis of the NYBC, NMDP and NHLBI Cord Blood Data. IOM Report. Cord blood: establishing a National Hematopoietic Stem Cell Bank Program. IOM. 2005;265–273

PII: S1083-8791(07)00572-1

doi: 10.1016/j.bbmt.2007.11.003

Biology of Blood and Marrow Transplantation
Volume 14, Issue 1 , Pages 1-6 , January 2008

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