ABO Incompatibility is Associated with Increased Non-Relapse and GVHD Related Mortality in Patients with Malignancies Treated with a Reduced Intensity Regimen: A Single Center Experience of 221 Patients

Cumulative incidence of acute GVHD (aGVHD): there is a trend for more severe aGVHD grade III-IV in ABO major mismatched (MM) group compared to ABO matched group (P =.098). (Here and in subsequent figures, absolute numbers of patients are shown in the appropriate fields.)

Non-relapse mortality is higher in ABO mismatched groups: P =.045 for minor and P =.023 for major mismatched groups, respectively.

GVHD-associated mortality is higher in the ABO major mismatched group compared with the ABO matched group (P =.021).

Distribution of major causes of death is different in ABO matched and mismatched groups, P =.037 according to chi-square test (ARDS indicates adult respiratory distress syndrome; MOF, multi-organ failure).

Kaplan-Meier probability of overall survival according to the degree of ABO incompatibility. (M and dotted line indicate median survival.)