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Volume 14, Issue 4 , Pages 449-457 , April 2008

Impact of Graft Cell Dose on Transplant Outcomes following Unrelated Donor Allogeneic Peripheral Blood Stem Cell Transplantation: Higher CD34⁺ Cell Doses Are Associated with Decreased Relapse Rates

Ryotaro Nakamura
- Division of Hematology/Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California
- Correspondence and reprint requests: Ryotaro Nakamura, MD, Division of Hematology/Hematopoietic Cell Transplantation, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, California 91010-3000.
Nademanee Auayporn
- Division of Hematology/Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California
David D. Smith
- Department of Biostatistics, City of Hope National Medical Center, Duarte, California
- These authors contributed equally to this article.
Joycelynne Palmer
- Department of Biostatistics, City of Hope National Medical Center, Duarte, California
- These authors contributed equally to this article.
Joel Y. Sun
- Division of Hematology/Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California
Jeffrey Schriber
- City of Hope/Samaritan Hematopoietic Cell Transplantation Program, Phoenix, Arizona
Vinod Pullarkat
- Division of Hematology/Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California
Pablo Parker
- Division of Hematology/Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California
Roberto Rodriguez
- Division of Hematology/Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California
Anthony Stein
- Division of Hematology/Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California
Joseph Rosenthal
- Division of Hematology/Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California
Shirong Wang
- Department of Transfusion Medicine, City of Hope National Medical Center, Duarte, California
Chatchada Karanas
- Division of Hematology/Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California
Karl Gaal
- Department of Anatomic Pathology, City of Hope National Medical Center, Duarte, California
David Senitzer
- Division of Hematology/Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California
Stephen J. Forman
- Division of Hematology/Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California

Received 13 December 2007 ,Accepted 6 February 2008.

Neutrophil recovery is associated with CD34⁺ cell dose. There was a significant inverse relationship between higher CD34⁺ cell dose (log scale) and faster neutrophil engraftment (r = −0.16, P = .035).

Neutrophil recovery is associated with CD34⁺ cell dose. There was a significant inverse relationship between higher CD34⁺ cell dose (log scale) and faster neutrophil engraftment (r = −0.16, P = .035).
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Effect of CD34+ cell dose on relapse (a), DFS (b), and OS (c).

Effect of CD34⁺ cell dose on relapse (a), DFS (b), and OS (c).
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Absolute lymphocyte count on day +30 posttransplant is associated with CD34+ cell dose. There was a highly significant correlation between CD34+ cell dose infused and ALC on day 30 posttransplant (r =

Absolute lymphocyte count on day +30 posttransplant is associated with CD34⁺ cell dose. There was a highly significant correlation between CD34⁺ cell dose infused and ALC on day 30 posttransplant (r = 0.378, P < .0001).
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Effect of CD34+ cell dose on relapse in myeloid cancers (a) and lymphoid cancers (b).

Effect of CD34⁺ cell dose on relapse in myeloid cancers (a) and lymphoid cancers (b).
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