Biology of Blood and Marrow Transplantation
Volume 14, Issue 5 , Pages 576-582 , May 2008

IV Busulfan Dose Individualization in Children undergoing Hematopoietic Stem Cell Transplant: Limited Sampling Strategies

  • L. Lee Dupuis

      Affiliations

    • Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
    • Department of Pharmacy, The Hospital for Sick Children, Toronto, Ontario, Canada
    • Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada
    • Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada
    • Corresponding Author InformationCorrespondence and reprint requests: L.L. Dupuis, RPh., MScPhm., FCSHP, Department of Pharmacy, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8.
    • ,
  • Cathryn Sibbald

      Affiliations

    • Department of Pharmacy, The Hospital for Sick Children, Toronto, Ontario, Canada
    • ,
  • Tal Schechter

      Affiliations

    • Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada
    • ,
  • Marc Ansari

      Affiliations

    • Division of Haematology/Oncology, CHU Ste-Justine, Montréal, Québec, Canada
    • ,
  • Adam Gassas

      Affiliations

    • Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada
    • ,
  • Yves Théorêt

      Affiliations

    • Department of Clinical Biochemistry, CHU Ste-Justine, Montréal, Québec, Canada
    • Department of Pharmacology, Université de Montréal, Montréal, Québec, Canada
    • ,
  • Nastya Kassir

      Affiliations

    • Faculty of Pharmacy, Université de Montréal, Montréal, Québec, Canada
    • ,
  • Martin A. Champagne

      Affiliations

    • Division of Haematology/Oncology, CHU Ste-Justine, Montréal, Québec, Canada
    • Department of Pediatrics, Université de Montréal, Montréal, Québec, Canada
    • ,
  • John Doyle

      Affiliations

    • Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada
    • Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada

Received 3 January 2008 ,Accepted 6 March 2008.

  • Image Result

    Development phase: BA plots of AUC7 versus AUC predicted by each limited sampling strategy (LSS). (A) 1-sample LSS; (B) 2-sample LSS; (C) 3-sample LSS.

    Development phase: BA plots of AUC7 versus AUC predicted by each limited sampling strategy (LSS). (A) 1-sample LSS; (B) 2-sample LSS; (C) 3-sample LSS.

  • Image Result

    Validation phase: BA plots of AUC7 versus AUC predicted by each limited sampling strategy (LSS). (A) 1-point LSS; (B) 2-point LSS; (C) 3-point LSS.

    Validation phase: BA plots of AUC7 versus AUC predicted by each limited sampling strategy (LSS). (A) 1-point LSS; (B) 2-point LSS; (C) 3-point LSS.

PII: S1083-8791(08)00111-0

doi: 10.1016/j.bbmt.2008.03.002

Biology of Blood and Marrow Transplantation
Volume 14, Issue 5 , Pages 576-582 , May 2008

Article Tools

* Image Usage & Resolution