Biology of Blood and Marrow Transplantation
Volume 14, Issue 5 , Pages 576-582 , May 2008

IV Busulfan Dose Individualization in Children undergoing Hematopoietic Stem Cell Transplant: Limited Sampling Strategies

  • L. Lee Dupuis

      Affiliations

    • Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
    • Department of Pharmacy, The Hospital for Sick Children, Toronto, Ontario, Canada
    • Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada
    • Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada
    • Corresponding Author InformationCorrespondence and reprint requests: L.L. Dupuis, RPh., MScPhm., FCSHP, Department of Pharmacy, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8.
    • ,
  • Cathryn Sibbald

      Affiliations

    • Department of Pharmacy, The Hospital for Sick Children, Toronto, Ontario, Canada
    • ,
  • Tal Schechter

      Affiliations

    • Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada
    • ,
  • Marc Ansari

      Affiliations

    • Division of Haematology/Oncology, CHU Ste-Justine, Montréal, Québec, Canada
    • ,
  • Adam Gassas

      Affiliations

    • Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada
    • ,
  • Yves Théorêt

      Affiliations

    • Department of Clinical Biochemistry, CHU Ste-Justine, Montréal, Québec, Canada
    • Department of Pharmacology, Université de Montréal, Montréal, Québec, Canada
    • ,
  • Nastya Kassir

      Affiliations

    • Faculty of Pharmacy, Université de Montréal, Montréal, Québec, Canada
    • ,
  • Martin A. Champagne

      Affiliations

    • Division of Haematology/Oncology, CHU Ste-Justine, Montréal, Québec, Canada
    • Department of Pediatrics, Université de Montréal, Montréal, Québec, Canada
    • ,
  • John Doyle

      Affiliations

    • Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada
    • Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada

Received 3 January 2008 ,Accepted 6 March 2008.

References 

  1. Dix SP, Wingard JR, Mullins RE, et al. Association of busulfan area under the curve with veno-occlusive disease following BMT. Bone Marrow Transplant. 1996;17:225–230
  2. Grochow LB. Busulfan disposition: the role of therapeutic monitoring in bone marrow transplantation induction regimens. Semin Oncol. 1993;20:18–25
  3. Slattery JT, Sanders JE, Buckner CD, et al. Graft-rejection and toxicity following bone marrow transplantation in relation to busulfan pharmacokinetics. Bone Marrow Transplant. 1995;16:31–42
  4. Slattery JT, Clift RA, Buckner CD, et al. Marrow transplantation for chronic myeloid leukemia: the influence of plasma busulfan levels on the outcome of transplantation. Blood. 1997;89:3055–3060
  5. Hassan M, Ehrsson H. Gas chromatographic determination of busulfan in plasma with electron-capture detection. J Chromatogr A. 1983;277:374–380
  6. Chen TL, Grochow LB, Hurowitz LA, Brundrett RB. Determination of busulfan in human plasma by gas chromatography with electron-capture detection. J Chromatogr A. 1988;425:303–309
  7. Rifai N, Sakamoto M, Lafi M, Guinan E. Measurement of plasma busulfan concentration by high-performance liquid chromatography with ultraviolet detection. Ther Drug Monit. 1997;19:169–174
  8. Vaughan WP, Carey D, Perry S, Westfall AO, Salzman DE. A limited sampling strategy for pharmacokinetic directed therapy with intravenous busulfan. Biol Blood Marrow Transplant. 2002;8:619–624
  9. Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet. 1986;1:307–310
  10. Nguyen L, Leger F, Lennon S, Puozzo C. Intravenous busulfan in adults prior to haematopoietic stem cell transplantation: a population pharmacokinetic study. Cancer Chemother Pharmacol. 2006;57:191–198

PII: S1083-8791(08)00111-0

doi: 10.1016/j.bbmt.2008.03.002

Biology of Blood and Marrow Transplantation
Volume 14, Issue 5 , Pages 576-582 , May 2008

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