Biology of Blood and Marrow Transplantation
Volume 14, Issue 6 , Pages 664-671 , June 2008

Reduced-Intensity Conditioning Allogeneic Transplantation from Unrelated Donors: Evaluation of Mycophenolate Mofetil Plus Cyclosporin A as Graft-versus-Host Disease Prophylaxis

  • Jose A. Pérez-Simón

      Affiliations

    • Servicio de Hematología, Hospital Clínico Universitario de Salamanca
    • Corresponding Author InformationCorrespondence and reprint requests: José A Pérez-Simón, MD, PhD, Servicio de Hematología, Hospital Clínico Universitario de Salamanca, Paseo de San Vicente 37007, Salamanca, Spain.
    • ,
  • Rodrigo Martino

      Affiliations

    • Hospital Santa Creu i Sant Pau, Barcelona, Spain
    • ,
  • Dolores Caballero

      Affiliations

    • Servicio de Hematología, Hospital Clínico Universitario de Salamanca
    • ,
  • David Valcarcel

      Affiliations

    • Hospital Santa Creu i Sant Pau, Barcelona, Spain
    • ,
  • Noemi Rebollo

      Affiliations

    • Servicio de Farmacia, Hospital Clínico Universitario de Salamanca, Spain
    • ,
  • Rafael de la Cámara

      Affiliations

    • Hospital de la Princesa, Madrid, Spain
    • ,
  • Javier Pérez de Oteiza

      Affiliations

    • Hospital Ramón y Cajal, Madrid, Spain
    • ,
  • Inmaculada Heras

      Affiliations

    • Hospital Morales Meseguer, Murcia, Spain
    • ,
  • Maria V. Calvo

      Affiliations

    • Servicio de Farmacia, Hospital Clínico Universitario de Salamanca, Spain
    • ,
  • Jordi Sierra

      Affiliations

    • Hospital Santa Creu i Sant Pau, Barcelona, Spain
    • ,
  • Jesús F. San Miguel

      Affiliations

    • Servicio de Hematología, Hospital Clínico Universitario de Salamanca
    • ,
  • Grupo Español de Trasplante Hematopoyético (GETH)

Received 21 February 2008 ,Accepted 19 March 2008.

  • Image Result

    Cumulative incidence of acute and chronic GVHD.

    Cumulative incidence of acute and chronic GVHD.

  • Image Result

    Concentration versus time profile of mycophenolic acid in 8 patients after oral or intravenous MMF administration. Patients 2, 3, and 6 are highlighted to show the high intraindividual variation of MP

    Concentration versus time profile of mycophenolic acid in 8 patients after oral or intravenous MMF administration. Patients 2, 3, and 6 are highlighted to show the high intraindividual variation of MPA pharmacokinetics.

  • Image Result
    Transplant related mortality.

    Transplant related mortality.

  • Image Result
    Event free and overall survival.

    Event free and overall survival.

PII: S1083-8791(08)00116-X

doi: 10.1016/j.bbmt.2008.03.007

Biology of Blood and Marrow Transplantation
Volume 14, Issue 6 , Pages 664-671 , June 2008

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