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Volume 14, Issue 6 , Pages 702-708 , June 2008

Allogeneic Hematopoietic Stem Cell Transplantation Using Reduced-Intensity Conditioning for Adult T Cell Leukemia/Lymphoma: Impact of Antithymocyte Globulin on Clinical Outcome

Ryuji Tanosaki
- Stem Cell Transplantation Unit, National Cancer Center Hospital, Tokyo, Japan
- Correspondence and reprint requests: Ryuji Tanosaki, MD, Stem Cell Transplantation Unit, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.
Naokuni Uike
- Department of Hematology, National Kyushu Cancer Center, Fukuoka, Japan
Atae Utsunomiya
- Department of Hematology, Imamura Bun-in Hospital, Kagoshima, Japan
Yoshio Saburi
- Department of Hematology, Oita Prefectural Hospital, Oita, Japan
Masato Masuda
- Cancer Center, University of the Ryukyus, Okinawa, Japan
Masao Tomonaga
- Department of Hematology, Molecular Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University, School of Medicine, Nagasaki, Japan
Tetsuya Eto
- Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan
Michihiro Hidaka
- Department of Hematology, National Hospital Organization Kumamoto Medical Center, Kumamoto, Japan
Mine Harada
- Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
Ilseung Choi
- Department of Hematology, National Kyushu Cancer Center, Fukuoka, Japan
Takeharu Yamanaka
- Institute for Clinical Research, National Kyushu Cancer Center, Fukuoka, Japan
Mari Kannagi
- Department of Immunotherapeutics, Tokyo Medical and Dental University, Medical Research Division, Tokyo, Japan
Masao Matsuoka
- Laboratory of Virus Immunology, Institute for Virus Research, Kyoto University, Kyoto, Japan
Jun Okamura
- Institute for Clinical Research, National Kyushu Cancer Center, Fukuoka, Japan

Received 25 February 2008 ,Accepted 25 March 2008.

Kaplan-Meier estimate of the cumulative probability of achieving complete donor chimera in the mononuclear cell fraction in peripheral blood. PBMNC indicates peripheral blood mononuclear cell; ATG, an

Kaplan-Meier estimate of the cumulative probability of achieving complete donor chimera in the mononuclear cell fraction in peripheral blood. PBMNC indicates peripheral blood mononuclear cell; ATG, antithymocyte globulin; ATG(+), patients treated with a conditioning regimen that included ATG in the previous study (n = 15); ATG(−), patients treated without ATG in the current study (n = 14). The achievement of complete donor chimera was significantly delayed in the current study compared to the previous study (P = .001).
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Cumulative incidence estimates of relapse and Kaplan-Meier survival estimates in comparison between the absence (the current study) and presence (the previous study) of ATG in the conditioning regimen

Cumulative incidence estimates of relapse and Kaplan-Meier survival estimates in comparison between the absence (the current study) and presence (the previous study) of ATG in the conditioning regimen. (A) Total and early relapse within 100 days tended to be decreased in the current study, but not significantly different (P = .26). (B) There was no significant difference in overall survival rate between with and without ATG (P = .28).
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The kinetics of the HTLV-1 proviral load within 6 months after RIST. The panel on the left (A) indicates the kinetics of HTLV-1 proviral load in the current study, whereas the panel on the right (B) s

The kinetics of the HTLV-1 proviral load within 6 months after RIST. The panel on the left (A) indicates the kinetics of HTLV-1 proviral load in the current study, whereas the panel on the right (B) shows the kinetics in the previous study. The HTLV-I proviral load was expressed as copy numbers per 1000 mononuclear cells (MNC). A load of <0.5 copies per 1000 MNC was considered to be undetectable. Closed circles indicate patients whose proviral load became undetectable at least once, whereas open circles indicate patients whose proviral load remained detectable.
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Kaplan-Meier estimate of overall survival for all patients treated in both studies according to the grade of aGVHD. Patients with grade I-II aGVHD had a significantly better overall survival compared

Kaplan-Meier estimate of overall survival for all patients treated in both studies according to the grade of aGVHD. Patients with grade I-II aGVHD had a significantly better overall survival compared to those without aGVHD (P = .0012). Severe aGVHD (grade III-IV) did not affect favorably in respect of overall survival compared to those without aGVHD (P = .39).
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