Biology of Blood and Marrow Transplantation
Volume 14, Issue 6 , Pages 702-708 , June 2008

Allogeneic Hematopoietic Stem Cell Transplantation Using Reduced-Intensity Conditioning for Adult T Cell Leukemia/Lymphoma: Impact of Antithymocyte Globulin on Clinical Outcome

  • Ryuji Tanosaki

      Affiliations

    • Stem Cell Transplantation Unit, National Cancer Center Hospital, Tokyo, Japan
    • Corresponding Author InformationCorrespondence and reprint requests: Ryuji Tanosaki, MD, Stem Cell Transplantation Unit, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.
    • ,
  • Naokuni Uike

      Affiliations

    • Department of Hematology, National Kyushu Cancer Center, Fukuoka, Japan
    • ,
  • Atae Utsunomiya

      Affiliations

    • Department of Hematology, Imamura Bun-in Hospital, Kagoshima, Japan
    • ,
  • Yoshio Saburi

      Affiliations

    • Department of Hematology, Oita Prefectural Hospital, Oita, Japan
    • ,
  • Masato Masuda

      Affiliations

    • Cancer Center, University of the Ryukyus, Okinawa, Japan
    • ,
  • Masao Tomonaga

      Affiliations

    • Department of Hematology, Molecular Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University, School of Medicine, Nagasaki, Japan
    • ,
  • Tetsuya Eto

      Affiliations

    • Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan
    • ,
  • Michihiro Hidaka

      Affiliations

    • Department of Hematology, National Hospital Organization Kumamoto Medical Center, Kumamoto, Japan
    • ,
  • Mine Harada

      Affiliations

    • Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    • ,
  • Ilseung Choi

      Affiliations

    • Department of Hematology, National Kyushu Cancer Center, Fukuoka, Japan
    • ,
  • Takeharu Yamanaka

      Affiliations

    • Institute for Clinical Research, National Kyushu Cancer Center, Fukuoka, Japan
    • ,
  • Mari Kannagi

      Affiliations

    • Department of Immunotherapeutics, Tokyo Medical and Dental University, Medical Research Division, Tokyo, Japan
    • ,
  • Masao Matsuoka

      Affiliations

    • Laboratory of Virus Immunology, Institute for Virus Research, Kyoto University, Kyoto, Japan
    • ,
  • Jun Okamura

      Affiliations

    • Institute for Clinical Research, National Kyushu Cancer Center, Fukuoka, Japan

Received 25 February 2008 ,Accepted 25 March 2008.

References 

  1. Uchiyama T, Yodoi J, Sagawa K, Takatsuki K, Uchino H. Adult T-cell leukemia: clinical and hematological features of 16 cases. Blood. 1977;50:481–492
  2. Shimoyama M, Ota K, Kikuchi M, et al. Major prognostic factors of adult patients with advanced T-cell lymphoma/leukemia. J Clin Oncol. 1988;6:1088–1097
  3. Shimoyama M Lymphoma Study Group. Diagnostic criteria and classification of clinical subtypes of adult T-cell leukemia-lymphoma. Br J Haematol. 1991;79:428–437
  4. Yamada Y, Tomonaga M, Fukuda H, et al. A new G-CSF-supproted combination chemotherapy, LSG15, for adult T-cell leukaemia-lymphoma: Japan Clinical Oncology Group Study 9303. Br J Haematol. 2001;113:375–382
  5. Tsukasaki K, Maeda T, Arimura K, et al. Poor outcome of autologous stem cell transplantation for adult T cell leukemia/lymphoma: a case report and review of the literature. Bone Marrow Transplant. 1999;23:87–89
  6. Tsukasaki K, Utsunomiya A, Fukuda H, et al. VCAP-AMP-VECP compared with biweekly CHOP for adult T-cell leukemia-lymphoma: Japan Clinical Oncology Group Study JCOG9801. J Clin Oncol. 2007;25:5458–5464
  7. Utsunomiya A, Miyazaki Y, Takatsuka Y, et al. Improved outcome of adult T cell leukemia/lymphoma with allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant. 2001;27:15–20
  8. Kami M, Hamaki T, Miyakoshi S, et al. Allogeneic haematopoietic stem cell transplantation for the treatment of adult T-cell leukaemia/lymphoma. Br J Haematol. 2003;120:304–309
  9. Fukushima T, Miyazaki Y, Honda S, et al. Allogeneic hematopoietic stem-cell transplantation provides sustained long-term survival for patients with adult T-cell leukemia/lymphoma. Leukemia. 2005;19:829–834
  10. Kato K, Kanda Y, Eto T, et al. Allogeneic bone marrow transplantation from unrelated HTLV-I-negative donors for adult T-cell leukemia/lymphoma: retrospective analysis of data from the Japan Marrow Donor Program. Biol Blood Marrow Transplant. 2007;13:90–99
  11. Okamura J, Utsunomiya A, Tanosaki R, et al. Allogeneic stem-cell transplantation with reduced conditioning intensity as a novel immunotherapy and antiviral therapy for adult T-cell leukemia/lymphoma. Blood. 2005;105:4143–4145
  12. Slavin S, Nagler A, Naparstek E, et al. Nonmyeloablative stem cell transplantation and cell therapy as an alternative to conventional bone marrow transplantation with lethal cytoreduction for the treatment of malignant and nonmalignant hematologic diseases. Blood. 1998;91:756–763
  13. Okamura J, Uike N, Utsunomiya A, Tanosaki R. Allogeneic stem cell transplantation for adult T-cell leukemia/lymphoma. Int J Hematol. 2007;86:118–125
  14. Thiede C, Florek M, Bornhauser M, et al. Rapid quantification of mixed chimerism using multiplex amplification of short tandem repeat markers and fluorescence detection. Bone Marrow Transplant. 1999;23:1055–1060
  15. National Cancer Center Institute. Common Terminology Criteria for Adverse Events v3.0 (CTCAE). http://ctep.cancer.gov/reporting/ctc_v30.html
  16. Glucksberg H, Storb R, Fefer A, et al. Clinical manifestation of graft-versus-host disease in human recipients of marrow from HLA-matched sibling donors. Transplantation. 1974;18:295–304
  17. Przepiorka D, Weisdorf D, Martin P, et al. Report of the 1994 consensus conference on acute GVHD grading. Bone Marrow Transplant. 1995;15:825–828
  18. Vogelsang GB. How I treat chronic graft-versus-host disease. Blood. 2001;97:1196–1201
  19. Sonoda J, Koriyama C, Yamamoto S, et al. HTLV-1 provirus load in peripheral blood lymphocytes of HTLV-1 carriers is diminished by green tea drinking. Cancer Sci. 2004;95:596–601
  20. Simon R, Wittes RE. Methodologic guidelines for reports of clinical trials. Cancer Treat Rep. 1985;69:1–3
  21. Nakai K, Mineishi S, Kami K, et al. Anti-thymocyte globulin affects the occurrence of acute and chronic graft-versus-host disease after a reduced-intensity conditioning regimen by modulating mixed chimerism induction and immune reconstitution. Transplantation. 2003;75:2135–2143
  22. Harashima N, Kurihara K, Utsunomiya A, et al. Graft-versus-human Tax response in adult T cell leukemia patients after hematopoietic stem cell transplantation. Cancer Res. 2004;64:391–399
  23. Kannagi M, Harashima N, Kurihara K, et al. Tumor immunity against adult T-cell leukemia. Cancer Sci. 2005;96:249–255
  24. Suzumiya J, Marutsuka K, Nabeshima K, et al. Autopsy findings in 47 cases of adult T-cell leukemia/lymphoma in Miyazaki Prefecture, Japan. Leuk Lymphoma. 1993;11:281–286
  25. Fujiwara H, Eizuru Y, Matsumoto T, et al. The significance of cytomegalovirus infection over the clinical course of adult T-cell leukemia/lymphoma. Microbiol Immunol. 2001;45:97–100

PII: S1083-8791(08)00131-6

doi: 10.1016/j.bbmt.2008.03.010

Biology of Blood and Marrow Transplantation
Volume 14, Issue 6 , Pages 702-708 , June 2008

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