Biology of Blood and Marrow Transplantation
Volume 14, Issue 7 , Pages 748-758 , July 2008

Classification of HLA-Matching for Retrospective Analysis of Unrelated Donor Transplantation: Revised Definitions to Predict Survival

  • Daniel Weisdorf

      Affiliations

    • University of Minnesota, Minneapolis, Minnesota
    • Corresponding Author InformationCorrespondence and reprint requests: Daniel Weisdorf, MD, University of Minnesota, Department of Medicine, 420 Delaware Street SE, MMC 480, Minneapolis, MN 55455.
    • ,
  • Stephen Spellman

      Affiliations

    • National Marrow Donor Program, Minneapolis, Minnesota
    • Center for International Blood and Marrow Transplant Research, Minneapolis, Minnesota
    • ,
  • Michael Haagenson

      Affiliations

    • Center for International Blood and Marrow Transplant Research, Minneapolis, Minnesota
    • ,
  • Mary Horowitz

      Affiliations

    • Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin
    • ,
  • Stephanie Lee

      Affiliations

    • Fred Hutchinson Cancer Research Center, Seattle, Washington
    • ,
  • Claudio Anasetti

      Affiliations

    • H. Lee Moffitt Cancer Center, Tampa, Florida
    • ,
  • Michelle Setterholm

      Affiliations

    • National Marrow Donor Program, Minneapolis, Minnesota
    • ,
  • Rebecca Drexler

      Affiliations

    • National Marrow Donor Program, Minneapolis, Minnesota
    • Center for International Blood and Marrow Transplant Research, Minneapolis, Minnesota
    • ,
  • Martin Maiers

      Affiliations

    • National Marrow Donor Program, Minneapolis, Minnesota
    • ,
  • Roberta King

      Affiliations

    • National Marrow Donor Program, Minneapolis, Minnesota
    • ,
  • Dennis Confer

      Affiliations

    • National Marrow Donor Program, Minneapolis, Minnesota
    • Center for International Blood and Marrow Transplant Research, Minneapolis, Minnesota
    • ,
  • John Klein

      Affiliations

    • Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin

Received 10 January 2008 ,Accepted 7 April 2008.

References 

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  2. Petersdorf EW, Longton GM, Anasetti C, et al. The significance of HLA-DRB1 matching on clinical outcome after HLA-A, B, DR identical unrelated donor marrow transplantation. Blood. 1995;86:1606–1613
  3. Petersdorf EW, Longton GM, Anasetti C, et al. Definition of HLA-DQ as a transplantation antigen. Proc Natl Acad Sci USA. 1996;93:15358–15363
  4. Petersdorf EW, Longton GM, Anasetti C, et al. Association of HLA-C disparity with graft failure after marrow transplantation from unrelated donors. Blood. 1997;89:1818–1823
  5. Petersdorf EW, Gooley TA, Anasetti C, et al. Optimizing outcome after unrelated marrow transplantation by comprehensive matching of HLA class I and II alleles in the donor and recipient. Blood. 1998;92:3515–3520
  6. Petersdorf EW, Hansen JA, Martin PJ, et al. Major-histocompatibility-complex class I alleles and antigens in hematopoietic-cell transplantation. N Engl J Med. 2001;345:1794–1800
  7. Petersdorf EW, Anasetti C, Martin PJ, et al. Limits of HLA mismatching in unrelated hematopoietic cell transplantation. Blood. 2004;104:2976–2980
  8. Sasazuki T, Juji T, Morishima Y, et al. Effect of matching of class I HLA alleles on clinical outcome after transplantation of hematopoietic stem cells from an unrelated donor. Japan Marrow Donor Program. N Engl J Med. 1998;339:1177–1185
  9. Morishima Y, Sasazuki T, Inoko H, et al. The clinical significance of human leukocyte antigen (HLA) allele compatibility in patients receiving a marrow transplant from serologically HLA-A, HLA-B, and HLA-DR matched unrelated donors. Blood. 2002;99:4200–4206
  10. Flomenberg N, Baxter-Lowe LA, Confer D, et al. Impact of HLA class I and class II high-resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C mismatching is associated with a strong adverse effect on transplantation outcome. Blood. 2004;104:1923–1930
  11. Petersdorf EW, Smith AG, Mickelson EM, et al. The role of HLA-DPB1 disparity in the development of acute graft-versus-host disease following unrelated donor marrow transplantation. Blood. 1993;81:1923–1932
  12. Petersdorf EW, Gooley T, Malkki M, et al. The biological significance of HLA-DP gene variation in haematopoietic cell transplantation. Br J Haematol. 2001;112:988–994
  13. Shaw BE, Marsh SG, Mayor NP, Russell NH, Madrigal JA. HLA-DPB1 matching status has significant implications for recipients of unrelated donor stem cell transplants. Blood. 2006;107:1220–1226
  14. Hurley CK, Fernandez-Vina M, Hildebrand WH, et al. A high degree of HLA disparity arises from limited allelic diversity: analysis of 1775 unrelated bone marrow transplant donor-recipient pairs. Hum Immunol. 2007;68:30–40
  15. Petersdorf EW, Kollman C, Hurley CK, et al. Effect of HLA class II gene disparity on clinical outcome in unrelated donor hematopoietic cell transplantation for chronic myeloid leukemia: the US National Marrow Donor Program Experience. Blood. 2001;98:2922–2929
  16. Ho VT, Kim HT, Liney D, et al. HLA-C mismatch is associated with inferior survival after unrelated donor non-myeloablative hematopoietic stem cell transplantation. Bone Marrow Transplant. 2006;37:845–850
  17. Petersdorf EW, Malkki M, Gooley TA, Martin PJ, Guo Z. MHC haplotype matching for unrelated hematopoietic cell transplantation. PLoS Med. 2007;4:e8
  18. Lee SJ, Klein J, Haagenson M, et al. The contribution of high resolution donor-recipient HLA matching to the success of unrelated donor marrow transplantation. Blood. 2007;110:4576–4583
  19. Spellman S, Maiers M, Setterholm M, et al. A standard definition of HLA matching for hematopoietic stem cell transplant outcomes. Biol Blood Marrow Transplant. 2006;12(Suppl 1):211
  20. Klein JP, Moeschberger ML. Survival Analysis: Statistical Methods for Censored and Truncated Data. New York: Springer-Verlag; 2003;

PII: S1083-8791(08)00147-X

doi: 10.1016/j.bbmt.2008.04.003

Biology of Blood and Marrow Transplantation
Volume 14, Issue 7 , Pages 748-758 , July 2008

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