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Volume 14, Issue 7 , Pages 759-765 , July 2008

Plasma Elevations of Tumor Necrosis Factor-Receptor-1 at Day 7 Postallogeneic Transplant Correlate with Graft-versus-Host Disease Severity and Overall Survival in Pediatric Patients

Carrie L. Kitko
- Department of Pediatrics, University of Michigan Medical School, Ann Arbor, Michigan
- Department of Medicine, University of Michigan Medical School, Ann Arbor, Michigan
- Correspondence and reprint requests: Carrie Kitko, MD, Blood and Marrow Transplant Program, 5303 Cancer Center, 1500 E. Medical Center Drive, SPC 5941, Ann Arbor, MI 48109-5941.
Sophie Paczesny
- Blood and Marrow Transplantation Program, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan
Gregory Yanik
- Department of Pediatrics, University of Michigan Medical School, Ann Arbor, Michigan
- Department of Medicine, University of Michigan Medical School, Ann Arbor, Michigan
Thomas Braun
- Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, Michigan
Dawn Jones
- Blood and Marrow Transplantation Program, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan
Joel Whitfield
- Blood and Marrow Transplantation Program, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan
Sung W. Choi
- Department of Pediatrics, University of Michigan Medical School, Ann Arbor, Michigan
- Department of Medicine, University of Michigan Medical School, Ann Arbor, Michigan
Raymond J. Hutchinson
- Department of Pediatrics, University of Michigan Medical School, Ann Arbor, Michigan
James L.M. Ferrara
- Department of Pediatrics, University of Michigan Medical School, Ann Arbor, Michigan
- Department of Medicine, University of Michigan Medical School, Ann Arbor, Michigan
John E. Levine
- Department of Pediatrics, University of Michigan Medical School, Ann Arbor, Michigan
- Department of Medicine, University of Michigan Medical School, Ann Arbor, Michigan

Received 29 November 2007 ,Accepted 9 April 2008.

Mean day 7 ratios are associated with maximum severity of GVHD (P = .02). Mean ± SEM; Grade 0-I, 1.7 ± 0.16; Grade II, 2.4 ± 0.68; Grade III-IV, 3.0 ± 0.62.

Mean day 7 ratios are associated with maximum severity of GVHD (P = .02). Mean ± SEM; Grade 0-I, 1.7 ± 0.16; Grade II, 2.4 ± 0.68; Grade III-IV, 3.0 ± 0.62.
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ROC curve. The AUC of the ROC curve is 0.63, P = .04. The cross indicates a threshold ratio of 2.5 corresponding to a specificity of 82% and a sensitivity of 31%.

ROC curve. The AUC of the ROC curve is 0.63, P = .04. The cross indicates a threshold ratio of 2.5 corresponding to a specificity of 82% and a sensitivity of 31%.
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Kaplan-Meier plot of OS in children based on the day 7 TNFR1 threshold of 2.5 (P = .04).

Kaplan-Meier plot of OS in children based on the day 7 TNFR1 threshold of 2.5 (P = .04).
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Kaplan-Meier plot of OS based on the day 7 TNFR1 threshold of 2.5 by donor source. MRD low = recipients of matched related donor HCT with a day 7 TNFR1 ratio ≤2.5, MRD high = recipients of matched rel

Kaplan-Meier plot of OS based on the day 7 TNFR1 threshold of 2.5 by donor source. MRD low = recipients of matched related donor HCT with a day 7 TNFR1 ratio ≤2.5, MRD high = recipients of matched related donor HCT with a day 7 TNFR1 ratio >2.5, MUD low = recipients of matched unrelated donor HCT with a day 7 TNFR1 ratio ≤2.5, MUD high = recipients of matched unrelated donor HCT with a day 7 TNFR1 ratio >2.5. P = .01, log rank test for trend.
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