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Volume 14, Issue 9, Supplement , Pages 16-22 , September 2008

Twenty Years of Unrelated Donor Bone Marrow Transplantation for Pediatric Acute Leukemia Facilitated by the National Marrow Donor Program

Margaret L. MacMillan
- Division of Pediatric Hematology, Oncology, and Blood and Marrow Transplantation, University of Minnesota Blood and Marrow Transplant Program, Minneapolis, Minnesota
- Correspondence and reprint requests: Margaret L. MacMillan, MD, University of Minnesota, Department of Pediatrics, 420 Delaware Street, Southeast, MMC 484, Minneapolis, MN 55455.
Stella M. Davies
- Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Gene O. Nelson
- National Marrow Donor Program, Minneapolis, Minnesota
Pintip Chitphakdithai
- National Marrow Donor Program, Minneapolis, Minnesota
Dennis L. Confer
- National Marrow Donor Program, Minneapolis, Minnesota
Roberta J. King
- National Marrow Donor Program, Minneapolis, Minnesota
Nancy A. Kernan
- Memorial Sloan-Kettering Cancer Center, New York, New York

Received 22 May 2008 ,Accepted 27 May 2008.

Number of pediatric transplants facilitated by the NMDP, by year and stem cell source.

Number of pediatric transplants facilitated by the NMDP, by year and stem cell source.
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Probability of survival after unrelated donor for children with acute leukemia, by transplant period. P-value at 2 years <.001.

Probability of survival after unrelated donor for children with acute leukemia, by transplant period. P-value at 2 years <.001.
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(A) Probability of survival after unrelated donor BMT for children with acute leukemia in first complete remission (CR1) at time of transplant, by transplant period. P-value at 2 years <.001. (B) Prob

(A) Probability of survival after unrelated donor BMT for children with acute leukemia in first complete remission (CR1) at time of transplant, by transplant period. P-value at 2 years <.001. (B) Probability of survival after unrelated donor BMT for children with acute leukemia in second complete remission (CR2) at time of transplant, by transplant period. P-value at 2 years = .001.
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Cumulative incidence of TRM in children with acute leukemia in CR1 or CR2 at the time of BMT, by transplant period. P-value <.001.

Cumulative incidence of TRM in children with acute leukemia in CR1 or CR2 at the time of BMT, by transplant period. P-value <.001.
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(A) Probability of survival after HLA well-matched unrelated donor BMT for children with acute leukemia, by transplant period. P-value at 2 years <.001. (B) Probability of survival after HLA mismatche

(A) Probability of survival after HLA well-matched unrelated donor BMT for children with acute leukemia, by transplant period. P-value at 2 years <.001. (B) Probability of survival after HLA mismatched unrelated donor BMT for children with acute leukemia, by transplant period. P-value at 2 years = .008.
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Probability of survival after unrelated donor BMT in 2003 to 2006 for children with acute leukemia, by disease state at time of transplant. P-value at 2 years <.001 for ALL, =.007 for AML.

Probability of survival after unrelated donor BMT in 2003 to 2006 for children with acute leukemia, by disease state at time of transplant. P-value at 2 years <.001 for ALL, =.007 for AML.
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Probability of survival after unrelated donor BMT for children with SAA by transplant period. Dataset includes additional recipients with non-myeloablative conditioning regimens. Pointwise P-value at

Probability of survival after unrelated donor BMT for children with SAA by transplant period. Dataset includes additional recipients with non-myeloablative conditioning regimens. Pointwise P-value at 2 years <.001.
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