Biology of Blood and Marrow Transplantation
Volume 14, Issue 9, Supplement , Pages 8-15 , September 2008

Twenty Years of Unrelated Donor Hematopoietic Cell Transplantation for Adult Recipients Facilitated by the National Marrow Donor Program

  • Chatchada Karanes

      Affiliations

    • City of Hope National Medical Center, Duarte, California
    • ,
  • Gene O. Nelson

      Affiliations

    • National Marrow Donor Program, Minneapolis, Minnesota
    • ,
  • Pintip Chitphakdithai

      Affiliations

    • National Marrow Donor Program, Minneapolis, Minnesota
    • ,
  • Edward Agura

      Affiliations

    • Baylor University Medical Center, Dallas, Texas
    • ,
  • Karen K. Ballen

      Affiliations

    • Massachusetts General Hospital, Boston, Massachusetts
    • ,
  • Charles D. Bolan

      Affiliations

    • Hematology Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland
    • ,
  • David L. Porter

      Affiliations

    • University of Pennsylvania Medical Center, Philadelphia, Pennsylvania
    • ,
  • Joseph P. Uberti

      Affiliations

    • Karmanos Cancer Institute, Detroit, Michigan
    • ,
  • Roberta J. King

      Affiliations

    • National Marrow Donor Program, Minneapolis, Minnesota
    • ,
  • Dennis L. Confer

      Affiliations

    • National Marrow Donor Program, Minneapolis, Minnesota
    • Corresponding Author InformationCorrespondence and reprint requests: Dennis L. Confer, MD, National Marrow Donor Program, 3001 Broadway Street NE, Suite 100, Minneapolis, MN 55413.

Received 5 June 2008 ,Accepted 5 June 2008.

  • Image Result

    Number of adult transplants in the study population for each disease by transplant period. Transplant numbers for all diseases except CML have increased over the 4 time periods.

    Number of adult transplants in the study population for each disease by transplant period. Transplant numbers for all diseases except CML have increased over the 4 time periods.

  • Image Result

    (A) Survival of adults with AML after HCT during 4 time periods. Survival is significantly better at 2 years post-transplant for patients transplanted during 2003-2006 compared to 1999-2002 (P ≤ .008)

    (A) Survival of adults with AML after HCT during 4 time periods. Survival is significantly better at 2 years post-transplant for patients transplanted during 2003-2006 compared to 1999-2002 (P ≤ .008) and also compared to 1996-1998 and 1987-1995 (P < .0001). (B) Survival of adults with AML after HLA well-matched HCT during 4 time periods. Survival is significantly better (P < .0001) at 2 years post-transplant for patients transplanted during 1999-2002 and 2003-2006 compared to patients transplanted during 1987-1998 and 1996-1998.

  • Image Result
    Survival of adults with ALL after HCT during 4 time periods. Survival is significantly better (P < .0001) at 2 years posttransplant for patients transplanted during 2003-2006 compared to patients tran

    Survival of adults with ALL after HCT during 4 time periods. Survival is significantly better (P < .0001) at 2 years posttransplant for patients transplanted during 2003-2006 compared to patients transplanted during the previous periods.

  • Image Result
    Survival of adults with MDS after HCT during 4 time periods. Survival is significantly better (P < .0001) at 2 years post-transplant for patients transplanted during 2003-2006 compared to patients tra

    Survival of adults with MDS after HCT during 4 time periods. Survival is significantly better (P < .0001) at 2 years post-transplant for patients transplanted during 2003-2006 compared to patients transplanted during the previous periods.

  • Image Result
    (A) Survival of adults with CML after HCT during 4 time periods. Survival is significantly better at 2 years post-transplant for patients transplanted during 2003-2006 compared to patients transplante

    (A) Survival of adults with CML after HCT during 4 time periods. Survival is significantly better at 2 years post-transplant for patients transplanted during 2003-2006 compared to patients transplanted during 1987-1995 and 1996-1998 (P < .0001), but was not significantly different compared to patients transplanted during 1999-2002. (B) Survival of adults with CML in CP1, CP2/accelerated, or blast phase after HCT. Survival is significantly better (P < .0001) at 2 years post-transplant for patients transplanted during CP1 compared to the other phases. Survival is also significantly better (P < .0001) at 2 years post-transplant for patients transplanted during CP2/accelerated phase compared to blast phase.

  • Image Result
    Survival of adults with SAA after HCT during 4 time periods. Survival is significantly better at 2 years post-transplant for patients transplanted during 2003-2006 compared to patients transplanted du

    Survival of adults with SAA after HCT during 4 time periods. Survival is significantly better at 2 years post-transplant for patients transplanted during 2003-2006 compared to patients transplanted during 1987-1995 and 1996-1998 (P < .0001), but was not significantly different compared to patients transplanted during 1999-2002.

 STATEMENT OF CONFLICT OF INTEREST: See Acknowledgements on page 15.

PII: S1083-8791(08)00249-8

doi: 10.1016/j.bbmt.2008.06.006

Biology of Blood and Marrow Transplantation
Volume 14, Issue 9, Supplement , Pages 8-15 , September 2008

Article Tools

* Image Usage & Resolution