Biology of Blood and Marrow Transplantation
Volume 14, Issue 9, Supplement , Pages 8-15 , September 2008

Twenty Years of Unrelated Donor Hematopoietic Cell Transplantation for Adult Recipients Facilitated by the National Marrow Donor Program

  • Chatchada Karanes

      Affiliations

    • City of Hope National Medical Center, Duarte, California
    • ,
  • Gene O. Nelson

      Affiliations

    • National Marrow Donor Program, Minneapolis, Minnesota
    • ,
  • Pintip Chitphakdithai

      Affiliations

    • National Marrow Donor Program, Minneapolis, Minnesota
    • ,
  • Edward Agura

      Affiliations

    • Baylor University Medical Center, Dallas, Texas
    • ,
  • Karen K. Ballen

      Affiliations

    • Massachusetts General Hospital, Boston, Massachusetts
    • ,
  • Charles D. Bolan

      Affiliations

    • Hematology Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland
    • ,
  • David L. Porter

      Affiliations

    • University of Pennsylvania Medical Center, Philadelphia, Pennsylvania
    • ,
  • Joseph P. Uberti

      Affiliations

    • Karmanos Cancer Institute, Detroit, Michigan
    • ,
  • Roberta J. King

      Affiliations

    • National Marrow Donor Program, Minneapolis, Minnesota
    • ,
  • Dennis L. Confer

      Affiliations

    • National Marrow Donor Program, Minneapolis, Minnesota
    • Corresponding Author InformationCorrespondence and reprint requests: Dennis L. Confer, MD, National Marrow Donor Program, 3001 Broadway Street NE, Suite 100, Minneapolis, MN 55413.

Received 5 June 2008 ,Accepted 5 June 2008.

References 

  1. McCullough J, Perkins HA, Hansen J. The National Marrow Donor Program with emphasis on the early years. Transfusion. 2006;46:1248–1255
  2. Weisdorf D, Spellman S, Haagenson M, et al. Classification of HLA-matching for retrospective analysis of unrelated donor transplantation: revised definitions to predict survival. Biol Blood Marrow Transplant. In press.
  3. Flomenberg N, Baxter-Lowe LA, Confer D, et al. Impact of HLA class I and class II high-resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C mismatching is associated with a strong adverse effect on transplantation outcome. Blood. 2004;104:1923–1930
  4. Kawase T, Morishima Y, Matsuo K, et al. High-risk HLA allele mismatch combinations responsible for severe acute graft-versus-host disease and implication for its molecular mechanism. Blood. 2007;110:2235–2241
  5. Lee SJ, Klein J, Haagenson M, et al. High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation. Blood. 2007;110:4576–4583
  6. Morishima Y, Sasazuki T, Inoko H, et al. The clinical significance of human leukocyte antigen (HLA) allele compatibility in patients receiving a marrow transplant from serologically HLA-A, HLA-B, and HLA-DR matched unrelated donors. Blood. 2002;99:4200–4206
  7. Petersdorf EW, Anasetti C, Martin PJ, et al. Limits of HLA mismatching in unrelated hematopoietic cell transplantation. Blood. 2004;104:2976–2980
  8. Petersdorf EW, Hansen JA, Martin PJ, et al. Major-histocompatibility-complex class I alleles and antigens in hematopoietic-cell transplantation. N Engl J Med. 2001;345:1794–1800
  9. Petersdorf EW, Kollman C, Hurley CK, et al. Effect of HLA class II gene disparity on clinical outcome in unrelated donor hematopoietic cell transplantation for chronic myeloid leukemia: the US National Marrow Donor Program Experience. Blood. 2001;98:2922–2929
  10. Shaw BE, Gooley T, Madrigal JA, Malkki M, Marsh SGE, Petersdorf EW. Clinical importance of HLA-DPB1 in haematopoietic cell transplantation. Tissue Antigens. 2007;69(Suppl. 1):36–41
  11. Confer DL, Miller JP. Optimal donor selection: beyond HLA. Biol Blood Marrow Transplant. 2007;13:83–86
  12. Hurley CK, Wagner JE, Setterholm MI, Confer DL. Advances in HLA: practical implications for selecting adult donors and cord blood units. Biol Blood Marrow Transplant. 2006;12:28–33
  13. Kollman C, Howe CWS, Anasetti C, et al. Donor characteristics as risk factors in recipients after transplantation of bone marrow from unrelated donors: the effect of donor age. Blood. 2001;98:2043–2051
  14. Lee SJ, Kamani N, Confer DL. Principles and tools for selection of umbilical cord blood and unrelated adult donor grafts. Biol Blood Marrow Transplant. 2008;14:112–119
  15. Eapen M, Logan BR, Confer DL, et al. Peripheral blood grafts from unrelated donors are associated with increased acute and chronic graft-versus-host disease without improved survival. Biol Blood Marrow Transplant. 2007;13:1461–1468
  16. Bacigalupo A, Sormani MP, Lamparelli T, et al. Reducing transplant-related mortality after allogeneic hematopoietic stem cell transplantation. Haematologica. 2004;89:1238–1247

 STATEMENT OF CONFLICT OF INTEREST: See Acknowledgements on page 15.

PII: S1083-8791(08)00249-8

doi: 10.1016/j.bbmt.2008.06.006

Biology of Blood and Marrow Transplantation
Volume 14, Issue 9, Supplement , Pages 8-15 , September 2008

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