Biology of Blood and Marrow Transplantation
Volume 14, Issue 12 , Pages 1323-1333 , December 2008

Influence of Age and Histology on Outcome in Adult Non-Hodgkin Lymphoma Patients Undergoing Autologous Hematopoietic Cell Transplantation (HCT): A Report from The Center For International Blood & Marrow Transplant Research (CIBMTR)

  • Hillard M. Lazarus

      Affiliations

    • University Hospitals Case Medical Center, Cleveland, Ohio
    • Corresponding Author InformationCorrespondence and reprint requests: Hillard M. Lazarus, MD, Department of Medicine, University Hospitals Case Medical Center, 11100 Euclid Avenue, Cleveland, OH 44106.
  • ,
  • Jeanette Carreras

      Affiliations

    • Lymphoma Working Committee of the Center for International Blood and Marrow Transplant Research (CIBMTR), Medical College of Wisconsin, Milwaukee, Wisconsin
  • ,
  • Christian Boudreau

      Affiliations

    • University of Waterloo, Waterloo, Ontario, Canada
  • ,
  • Fausto R. Loberiza Jr.

      Affiliations

    • University of Nebraska Medical Center, Omaha, Nebraska
  • ,
  • James O. Armitage

      Affiliations

    • University of Nebraska Medical Center, Omaha, Nebraska
  • ,
  • Brian J. Bolwell

      Affiliations

    • Cleveland Clinic Foundation, Cleveland, Ohio
  • ,
  • César O. Freytes

      Affiliations

    • University of Texas Health Science Center, San Antonio, Texas
  • ,
  • Robert Peter Gale

      Affiliations

    • Center for Advanced Studies in Leukemia, Los Angeles, Californai
  • ,
  • John Gibson

      Affiliations

    • Royal Prince Alfred Hospital, Camperdown, Australia
  • ,
  • Gregory A. Hale

      Affiliations

    • St. Jude Children Research Center, Memphis, Tennessee
  • ,
  • David J. Inwards

      Affiliations

    • Mayo Clinic, Rochester, Minnesota
  • ,
  • Charles F. LeMaistre

      Affiliations

    • Texas Transplant Institute, San Antonio, Texas
  • ,
  • Dipnarine Maharaj

      Affiliations

    • South Florida Bone Marrow Stem Cell Institute, Boynton Beach, Florida
  • ,
  • David I. Marks

      Affiliations

    • Bristol Children's Hospital, Bristol, United Kingdom
  • ,
  • Alan M. Miller

      Affiliations

    • Tulane University Medical Center, New Orleans, Louisiana
  • ,
  • Santiago Pavlovsky

      Affiliations

    • Fundaleu, Buenos Aires, Argentina
  • ,
  • Harry C. Schouten

      Affiliations

    • University Hospitals Maastricht, Maastricht, The Netherlands
  • ,
  • Koen van Besien

      Affiliations

    • University of Chicago, Chicago, Illinois
  • ,
  • Julie M. Vose

      Affiliations

    • University of Nebraska Medical Center, Omaha, Nebraska
  • ,
  • Jacob D. Bitran

      Affiliations

    • Advocate Lutheran General Hospital, Park Ridge, Illinois
  • ,
  • Issa F. Khouri

      Affiliations

    • MD Anderson Cancer Research Center, Houston, Texas
  • ,
  • Philip L. McCarthy

      Affiliations

    • Roswell Park Cancer Institute, Buffalo, New York
  • ,
  • Hongmei Yu

      Affiliations

    • Shanxi Medical University, People's Republic of China
  • ,
  • Philip Rowlings

      Affiliations

    • Newcastile Mater Hospital, Waratah, Australia
  • ,
  • Derek S. Serna

      Affiliations

    • Lymphoma Working Committee of the Center for International Blood and Marrow Transplant Research (CIBMTR), Medical College of Wisconsin, Milwaukee, Wisconsin
  • ,
  • Mary M. Horowitz

      Affiliations

    • Lymphoma Working Committee of the Center for International Blood and Marrow Transplant Research (CIBMTR), Medical College of Wisconsin, Milwaukee, Wisconsin
  • ,
  • J. Douglas Rizzo

      Affiliations

    • Lymphoma Working Committee of the Center for International Blood and Marrow Transplant Research (CIBMTR), Medical College of Wisconsin, Milwaukee, Wisconsin

Received 15 July 2008 ,Accepted 12 September 2008.

References 

  1. O'Reilly SE, Connors JM, Macpherson N, et al. Malignant lymphomas in the elderly. Clin Geriatr Med. 1997;13:251–263
  2. Devesa SS, Fears T. Non-Hodgkin's lymphoma time trends: United States and international data. Cancer Res. 1992;52:5432s–5440s
  3. Shipp MA, Anderson JR, et al. A predictive model for aggressive non-Hodgkin's lymphoma. The Internationl Non-Hodgkin's Lymphoma Prognostic Factors Project. N Engl J Med. 1993;987–994
  4. Solal-Celigny P, Roy P, Colombat P, et al. Follicular lymphoma international prognostic index. Blood. 2004;104:1258–1265
  5. Miller CB, Piantadosi S, Vogelsang GB, et al. Impact of age on outcome of patients with cancer undergoing autologous bone marrow transplant. J Clin Oncol. 1996;14:1327–1332
  6. Kusnierz-Glaz CR, Schlegel PG, Wong RM, et al. Influence of age on the outcome of 500 autologous bone marrow transplant procedures for hematologic malignancies. J Clin Oncol. 1997;15:18–25
  7. Weaver CH, Schwartzberg LS, Hainsworth J, et al. Treatment-related mortality in 1000 consecutive patients receiving high-dose chemotherapy and peripheral blood progenitor cell transplantation in community cancer centers. Bone Marrow Transplant. 1997;19:671–678
  8. Freedman AS, Neuberg D, Mauch P, et al. Long-term follow-up of autologous bone marrow transplantation in patients with relapsed follicular lymphoma. Blood. 1999;94:3325–3333
  9. Philip T, Guglielmi C, Hagenbeek A, et al. Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin's lymphoma. N Engl J Med. 1995;333:1540–1545
  10. Krishnan A, Bhatia S, Slovak ML, et al. Predictors of therapy-related leukemia and myelodysplasia following autologous transplantation for lymphoma: an assessment of risk factors. Blood. 2000;95:1588–1593
  11. Stiff PJ, Dahlberg S, Forman SJ, et al. Autologous bone marrow transplantation for patients with relapsed or refractory diffuse aggressive non-Hodgkin's lymphoma: value of augmented preparative regimens—a Southwest Oncology Group trial. J Clin Oncol. 1998;16:48–55
  12. Bierman PJ, Vose JM, Anderson JR, et al. High-dose therapy with autologous hematopoietic rescue for follicular low-grade non-Hodgkin's lymphoma. J Clin Oncol. 1997;15:445–450
  13. National Hospital Discharge Survey for 1990 and 1991. Hyattsville, MD: U.S. Department of Health and Human Services PHS, Centers for Disease Control, National Center for Health Statistics, Hospital Care Statistics Branch.
  14. Graves E. Detailed diagnoses and procedures. National Hospital Discharge Survey, 1989. Hyattsville, MD: U.S. Department of Health and Human Services PHS; 1991;
  15. Curtis RE, Rowlings PA, Deeg HJ, et al. Solid cancers after bone marrow transplantation. N Engl J Med. 1997;336:897–904
  16. Silberman G, Crosse MG, Peterson EA, et al. Availability and appropriateness of allogeneic bone marrow transplantation for chronic myeloid leukemia in 10 countries. N Engl J Med. 1994;331:1063–1067
  17. Kaplan EL, Meier P. Nonparametric estimation from in complete observations. J Am Stat Assoc. 1958;53:457–481
  18. Contal C, O'Quigley J. An application of change point methods in studying the effect of age on survival in breast cancer. Comput Stat Data Anal. 1999;30:253–270
  19. Cox DR. Regression models and life tables. J R Stat Soc B. 1972;34:187–220
  20. Therneau TM, Grambsch PM. Modeling survival data: extending the Cox model. New York: Springer-Verlag; 2000;
  21. Andersen PK, Klein JP, Zhang MJ. Testing for centre effects in multi-centre survival studies: a Monte Carlo comparison of fixed and random effects tests. Stat Med. 1999;18:1489–1500
  22. Sweetenham JW, Pearce R, Philip T, et al. High-dose therapy and autologous bone marrow transplantation for intermediate and high grade non-Hodgkin's lymphoma in patients aged 55 years and over: results from the European Group for Bone Marrow Transplantation. The EBMT Lymphoma Working Party. Bone Marrow Transplant. 1994;14:981–987
  23. Stamatoullas A, Fruchart C, Khalfallah S, et al. Peripheral blood stem cell transplantation for relapsed or refractory aggressive lymphoma in patients over 60 years of age. Bone Marrow Transplant. 1997;19:31–35
  24. Moreau P, Milpied N, Voillat L, et al. Peripheral blood stem cell transplantation as front-line therapy in patients aged 61 to 65 years: a pilot study. Bone Marrow Transplant. 1998;21:1193–1196
  25. Mazza P, Palazzo G, Amurri B, et al. Analysis of feasibility of myeloablative therapy and autologous peripheral stem cell (PBSC) transplantation in the elderly: an interim report. Bone Marrow Transplant. 1999;23:1273–1278
  26. Jantunen E, Mahlamaki E, Nousiainen T. Feasibility and toxicity of high-dose chemotherapy supported by peripheral blood stem cell transplantation in elderly patients (≥60 years) with non-Hodgkin's lymphoma: comparison with patients <60 years treated within the same protocol. Bone Marrow Transplant. 2000;26:737–741
  27. Gopal AK, Gooley TA, Golden JB, et al. Efficacy of high-dose therapy and autologous hematopoietic stem cell transplantation for non-Hodgkin's lymphoma in adults 60 years of age and older. Bone Marrow Transplant. 2001;27:593–599
  28. Bitran JD, Klein L, Link D, et al. High-dose myeloablative therapy and autologous peripheral blood progenitor cell transplantation for elderly patients (greater than 65 years of age) with relapsed large cell lymphoma. Biol Blood Marrow Transplant. 2003;9:383–388
  29. Leger CS, Bredeson C, Kearns B, et al. Autologous blood and marrow transplantation in patients 60 years and older. Biol Blood Marrow Transplant. 2000;6:204–210
  30. Vose JM, Rizzo DJ, Tao-Wu J, et al. Autologous transplantation for diffuse aggressive non-Hodgkin lymphoma in first relapse or second remission. Biol Blood Marrow Transplant. 2004;10:116–127
  31. Schmitz N, Linch DC, Dreger P, et al. Randomised trial of filgrastim-mobilised peripheral blood progenitor cell transplantation versus autologous bone-marrow transplantation in lymphoma patients. Lancet. 1996;347:353–357
  32. Buadi FK, Micallef IN, Ansell SM, et al. Autologous hematopoietic stem cell transplantation for older patients with relapsed non-Hodgkin's lymphoma. Bone Marrow Transplant. 2006;37:1017–1022
  33. Wildes TM, Augustin KM, Sempek D, et al. Comorbidities, not age, impact outcomes in autologous stem cell transplant for relapsed non-Hodgkin lymphoma. Biol Blood Marrow Transplant. 2008;14:840–846
  34. Hosing C, Saliba RM, Okoroji GJ, et al. High-dose chemotherapy and autologous hematopoietic progenitor cell transplantation for non-Hodgkin's lymphoma in patients >65 years of age. Ann Oncol. 2008;19:1166–1171
  35. Radich JP, Gooley T, Bensinger W, et al. HLA-matched related hematopoietic cell transplantation for chronic-phase CML using a targeted busulfan and cyclophosphamide preparative regimen. Blood. 2003;102:31–35
  36. Press OW, Eary JF, Gooley T, et al. A phase I/II trial of iodine-131-tositumomab (anti-CD20), etoposide, cyclophosphamide, and autologous stem cell transplantation for relapsed B-cell lymphomas. Blood. 2000;96:2934–2942
  37. Gopal AK, Rajendran JG, Petersdorf SH, et al. High-dose chemo-radioimmunotherapy with autologous stem cell support for relapsed mantle cell lymphoma. Blood. 2000;99:3158–3162

 Financial disclosure: See Acknowledgments on page 1332.

PII: S1083-8791(08)00398-4

doi: 10.1016/j.bbmt.2008.09.008

Biology of Blood and Marrow Transplantation
Volume 14, Issue 12 , Pages 1323-1333 , December 2008