Biology of Blood and Marrow Transplantation
Volume 14, Issue 12 , Pages 1334-1340 , December 2008

Unrelated Donor Hematopoietic Cell Transplantation: Factors Associated with a Better HLA Match

  • Jason Dehn

      Affiliations

    • National Marrow Donor Program, Minneapolis, Minnesota
    • Corresponding Author InformationCorrespondence and reprint requests: Jason Dehn, MPH, National Marrow Donor Program, 3001 Broadway Street NE, Broadway Ridge, Suite 100, Minneapolis, MN 55413-1753.
    • ,
  • Mukta Arora

      Affiliations

    • University of Minnesota, Minneapolis, Minnesota
    • ,
  • Stephen Spellman

      Affiliations

    • National Marrow Donor Program, Minneapolis, Minnesota
    • ,
  • Michelle Setterholm

      Affiliations

    • National Marrow Donor Program, Minneapolis, Minnesota
    • ,
  • Mary Horowitz

      Affiliations

    • Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin
    • ,
  • Dennis Confer

      Affiliations

    • National Marrow Donor Program, Minneapolis, Minnesota
    • ,
  • Daniel Weisdorf

      Affiliations

    • University of Minnesota, Minneapolis, Minnesota

Received 20 June 2008 ,Accepted 11 September 2008.

References 

  1. Petersdorf EW, Gooley TA, Anasetti C, et al. Optimizing outcome after unrelated marrow transplantation by comprehensive matching of HLA class I and II alleles in the donor and recipient. Blood. 1998;92:3515–3520
  2. Petersdorf EW, Hansen JA, Martin PJ, et al. Major-histocompatibility-complex class I alleles and antigens in hematopoietic-cell transplantation. N Engl J Med. 2001;345:1794–1800
  3. Morishima Y, Sasazuki T, Inoko H, et al. The clinical significance of human leukocyte antigen (HLA) allele compatibility in patients receiving a marrow transplant from serologically HLA-A, HLA-B, and HLA-DR matched unrelated donors. Blood. 2002;99:4200–4206
  4. Sasazuki T, Juji T, Morishima Y, et al. Effect of matching of class I HLA alleles on clinical outcome after transplantation of hematopoietic stem cells from an unrelated donor. Japan Marrow Donor Program. N Engl J Med. 1998;339:1177–1185
  5. Lee SJ, Klein J, Haagenson M, et al. High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation. Blood. 2007;110:4576–4583
  6. Flomenberg N, Baxter-Lowe LA, Confer D, et al. Impact of HLA class I and class II high-resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C mismatching is associated with a strong adverse effect on transplantation outcome. Blood. 2004;104:1923–1930
  7. Petersdorf EW, Anasetti C, Martin PJ, et al. Limits of HLA mismatching in unrelated hematopoietic cell transplantation. Blood. 2004;104:2976–2980
  8. Hurley CK, Fernandez-Vina M, Hildebrand WH, et al. A high degree of HLA disparity arises from limited allelic diversity: analysis of 1775 unrelated bone marrow transplant donor-recipient pairs. Hum Immunol. 2007;68:30–40
  9. Shaw BE, Marsh SG, Mayor NP, Russell NH, Madrigal JA. HLA-DPB1 matching status has significant implications for recipients of unrelated donor stem cell transplants. Blood. 2006;107:1220–1226
  10. Weisdorf D, Spellman S, Haagenson M, et al. Classification of HLA-matching for retrospective analysis of unrelated donor transplantation: revised definitions to predict survival. Biol Blood Marrow Transplant. 2008;14:748–758
  11. Armstrong BG, Sloan M. Ordinal regression models for epidemiologic data. Am J Epidemiol. 1989;129:191–204
  12. Bender R, Benner A. Calculating ordinal regression models in SAS and S-Plus. Biometrical J. 2000;42:677–699
  13. Davis JW, Buck K, Dorr L, et al. Evaluation of unrelated donor search strategy proficiencies. Biol Blood Marrow Transplant. 2006;12:31;[abstract 79]
  14. Bray RA, Hurley CK, Kamani NR, et al. National Marrow Donor Program HLA matching guidelines for unrelated adult hematopoietic cell transplants. Biol Blood Marrow Transplant. 2008;14:45–53

 Financial disclosure: See Acknowledgments on page 1339.

PII: S1083-8791(08)00399-6

doi: 10.1016/j.bbmt.2008.09.009

Biology of Blood and Marrow Transplantation
Volume 14, Issue 12 , Pages 1334-1340 , December 2008

Article Tools

* Image Usage & Resolution