Biology of Blood and Marrow Transplantation
Volume 14, Issue 12 , Pages 1356-1364 , December 2008

Autologous Hematopoietic Stem Cell Transplantation in Extranodal Natural Killer/T Cell Lymphoma: A Multinational, Multicenter, Matched Controlled Study

  • Jeeyun Lee

      Affiliations

    • Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    • ,
  • Wing-Yan Au

      Affiliations

    • Department of Medicine, Queen Mary Hospital, Hong Kong
    • ,
  • Min Jae Park

      Affiliations

    • Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    • ,
  • Junji Suzumiya

      Affiliations

    • First Department of Internal Medicine, Fukuoka University School of Medicine, Fukuoka, Japan
    • ,
  • Shigeo Nakamura

      Affiliations

    • Department of Pathology, Nagoya University School of Medicine, Nagoya, Japan
    • ,
  • Jun-Ichi Kameoka

      Affiliations

    • Department of Rheumatology and Haematology, Tohoku University School of Medicine, Sendai, Japan
    • ,
  • Chikara Sakai

      Affiliations

    • Department of Hematology and Oncology, Chiba Cancer Center, Chiba, Japan
    • ,
  • Kazuo Oshimi

      Affiliations

    • Department of Hematology, Juntendo University, Tokyo, Japan
    • ,
  • Yok-Lam Kwong

      Affiliations

    • Department of Medicine, Queen Mary Hospital, Hong Kong
    • ,
  • Raymond Liang

      Affiliations

    • Department of Medicine, Queen Mary Hospital, Hong Kong
    • ,
  • Harry Yiu

      Affiliations

    • Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong
    • ,
  • Kam-Hung Wong

      Affiliations

    • Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong
    • ,
  • Hoi-Ching Cheng

      Affiliations

    • Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong
    • ,
  • Baek-Yeol Ryoo

      Affiliations

    • Department of Hematology-Oncology, Korea Cancer Center Hospital, Seoul, Korea
    • ,
  • Cheolwon Suh

      Affiliations

    • Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    • ,
  • Young Hyeh Ko

      Affiliations

    • Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    • ,
  • Kihyun Kim

      Affiliations

    • Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    • ,
  • Jae-Won Lee

      Affiliations

    • Department of Statistics, Korea University, Seoul, Korea
    • ,
  • Won Seog Kim

      Affiliations

    • Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    • Corresponding Author InformationCorrespondence and reprint requests: Won Seog Kim, MD, PhD, Division of Hematology/Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong Kangnam-Gu, Seoul 135-710 Korea.
    • ,
  • Ritsuro Suzuki

      Affiliations

    • Department of Hematopoietic Stem Cell Transplantation Data Management, Nagoya University School of Medicine, Nagoya, Japan
    • Corresponding Author InformationRitsuro Suzuki, MD, PhD, Department of Hematopoietic Stem Cell Transplantation Data Management, Nagoya University School of Medicine, 1-1-20 Daiko-Minami, Higashi-Ku, Nagoya 461-0047, Japan.

References 

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  3. Lee J, Park YH, Kim WS, et al. Extranodal nasal-type NK/T-cell lymphoma: elucidating clinical prognostic factors for risk-based stratification of therapy. Eur J Cancer. 2005;41:1402–1408
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  5. Chim CS, Ma SY, Au WY, et al. Primary nasal natural killer cell lymphoma: long-term treatment outcome and relationship with the International Prognostic Index. Blood. 2004;103:216–221
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  11. Kwong YL. Natural killer-cell malignancies: diagnosis and treatment. Leukemia. 2005;19:2186–2194
  12. Li CC, Tien HF, Tang JL, et al. Treatment outcome and pattern of failure in 77 patients with sinonasal natural killer/T-cell or T-cell lymphoma. Cancer. 2004;100:366–375
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  14. Suzuki R, Suzumiya J, Nakamura S, et al. Hematopoietic stem cell transplantation for natural killer-cell lineage neoplasms. Bone Marrow Transplant. 2006;37:425–431
  15. Kim HJ, Bang SM, Lee J, et al. High-dose chemotherapy with autologous stem cell transplantation in extranodal NK/T-cell lymphoma: a retrospective comparison with non-transplantation cases. Bone Marrow Transplant. 2006;37:819–824
  16. Liang R, Chen F, Lee CK, et al. Autologous bone marrow transplantation for primary nasal T/NK cell lymphoma. Bone Marrow Transplant. 1997;19:91–93
  17. Takenaka K, Shinagawa K, Maeda Y, et al. High-dose chemotherapy with hematopoietic stem cell transplantation is effective for nasal and nasal-type CD56+ natural killer cell lymphomas. Leuk Lymphoma. 2001;42:1297–1303
  18. Au W, Intragumtornchai T, Nakamura S, et al. Clinical and pathological differences between nasal and nasal-type NK/T cell lymphomas: A summary of 136 cases from the international T cell lymphoma (ITCL) project. [abstract] Blood. 2006;292:209A
  19. Rodriguez J, Caballero MD, Gutierrez A, et al. High-dose chemotherapy and autologous stem cell transplantation in patients with peripheral T-cell lymphoma not achieving complete response after induction chemotherapy: the GEL-TAMO experience. Haematologica. 2003;88:1372–1377
  20. Kim MK, Kim S, Lee SS, et al. High-dose chemotherapy and autologous stem cell transplantation for peripheral T-cell lymphoma: complete response at transplant predicts survival. Ann Hematol. 2007;86:435–442
  21. Shipp MA, Abeloff MD, Antman KH, et al. International Consensus Conference on High-Dose Therapy with Hematopoietic Stem Cell Transplantation in Aggressive Non-Hodgkin's Lymphomas: report of the jury. J Clin Oncol. 1999;17:423–429
  22. Coiffier B, Brousse N, Peuchmaur M, et al. Peripheral T-cell lymphomas have a worse prognosis than B-cell lymphomas: a prospective study of 361 immunophenotyped patients treated with the LNH-84 regimen. The GELA (Groupe d'Etude des Lymphomes Agressives). Ann Oncol. 1990;1:45–50
  23. Rodriguez J, Caballero MD, Gutierrez A, et al. High-dose chemotherapy and autologous stem cell transplantation in peripheral T-cell lymphoma: the GEL-TAMO experience. Ann Oncol. 2003;14:1768–1775
  24. Rodriguez J, Conde E, Gutierrez A, et al. Prolonged survival of patients with angioimmunoblastic T-cell lymphoma after high-dose chemotherapy and autologous stem cell transplantation: the GELTAMO experience. Eur J Haematol. 2007;78:290–296
  25. Corradini P, Dodero A, Zallio F, et al. Graft-versus-lymphoma effect in relapsed peripheral T-cell non-Hodgkin's lymphomas after reduced-intensity conditioning followed by allogeneic transplantation of hematopoietic cells. J Clin Oncol. 2004;22:2172–2176
  26. Wulf GG, Hasenkamp J, Jung W, et al. Reduced intensity conditioning and allogeneic stem cell transplantation after salvage therapy integrating alemtuzumab for patients with relapsed peripheral T-cell non-Hodgkin's lymphoma. Bone Marrow Transplant. 2005;36:271–273
  27. Vose JM. High-dose chemotherapy and hematopoietic stem cell transplantation for relapsed or refractory diffuse large-cell non-Hodgkin's lymphoma. Ann Oncol. 1998;9(Suppl 1):S1–S3
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  29. Suzuki R, Suzumiya J, Nakamura S, et al. Natural killer (NK)-cell neoplasms: aggressive NK-cell leukemia and extranodal NK-cell lymphoma, nasal type. Presented at the 9th International Conference on Malignant Lymphomas; Lugano, 2005; abstract 316.

 J. Lee and W.Y. Au contributed equally as first authors.

 The authors have no conflicts of interest to declare.

 Financial disclosure: See Acknowledgments on page 1364.

PII: S1083-8791(08)00405-9

doi: 10.1016/j.bbmt.2008.09.014

Biology of Blood and Marrow Transplantation
Volume 14, Issue 12 , Pages 1356-1364 , December 2008

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