Biology of Blood and Marrow Transplantation
Volume 14, Issue 12 , Pages 1365-1372 , December 2008

Albuminuria in Hematopoietic Cell Transplantation Patients: Prevalence, Clinical Associations, and Impact on Survival

  • Sangeeta R. Hingorani

      Affiliations

    • Department of Pediatrics, University of Washington, Seattle, Washington
    • Corresponding Author InformationCorrespondence and reprint requests: Sangeeta R. Hingorani, MD, MPH, Children's Hospital and Regional Medical Center, 4800 Sand Point Way NE, A-7931, Seattle, WA 98105.
    • ,
  • Kristy Seidel

      Affiliations

    • Department of Pediatrics, University of Washington, Seattle, Washington
    • ,
  • Armando Lindner

      Affiliations

    • Department of Medicine, University of Washington, Seattle, Washington
    • VA Puget Sound Health Care System, Seattle, Washington
    • ,
  • Tia Aneja

      Affiliations

    • Department of Pediatrics, University of Washington, Seattle, Washington
    • ,
  • Gary Schoch

      Affiliations

    • Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington
    • ,
  • George McDonald

      Affiliations

    • Department of Medicine, University of Washington, Seattle, Washington
    • Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington

Received 18 March 2008 ,Accepted 17 September 2008.

References 

  1. Russo LM, Sandoval RM, McKee M, et al. The normal kidney filters nephrotic levels of albumin retrieved by proximal tubule cells: retrieval is disrupted in nephrotic states. Kidney Int. 2007;71:504–513
  2. Hilliard L, Russo L, Comper W. Insights into the relationship between hypertension and albuminuria. Curr Hypertens Rev. 2007;3:29–37
  3. Hillege HL, Fidler V, Diercks GF, et al. Urinary albumin excretion predicts cardiovascular and noncardiovascular mortality in general population. Circulation. 2002;106:1777–1782
  4. Segura J, Campo C, Ruilope LM. Effect of proteinuria and glomerular filtration rate on cardiovascular risk in essential hypertension. Kidney Int Suppl. 2004;S45–S49
  5. Verhave JC, Hillege HL, Burgerhof JG, et al. Cardiovascular risk factors are differently associated with urinary albumin excretion in men and women. J Am Soc Nephrol. 2003;14:1330–1335
  6. Mahmud N, Stinson J, O'Connell MA, et al. Microalbuminuria in inflammatory bowel disease. Gut. 1994;35:1599–1604
  7. Abid O, Sun Q, Sugimoto K, et al. Predictive value of microalbuminuria in medical ICU patients: results of a pilot study. Chest. 2001;120:1984–1988
  8. Hillege HL, Janssen WM, Bak AA, et al. Microalbuminuria is common, also in a nondiabetic, nonhypertensive population, and an independent indicator of cardiovascular risk factors and cardiovascular morbidity. J Intern Med. 2001;249:519–526
  9. Mann JF, Gerstein HC, Yi QL, et al. Development of renal disease in people at high cardiovascular risk: results of the HOPE randomized study. J Am Soc Nephrol. 2003;14:641–647
  10. Pinto-Sietsma SJ, Janssen WM, Hillege HL, et al. Urinary albumin excretion is associated with renal functional abnormalities in a nondiabetic population. J Am Soc Nephrol. 2000;11:1882–1888
  11. Carella AM, Champlin R, Slavin S, et al. Mini-allografts: ongoing trials in humans. Bone Marrow Transplant. 2000;25:345–350
  12. Chao NJ. Pharmacology and use of immunosuppressive agents after hematopoietic cell transplantation. In:  Thomas ED,  Blume KG,  Forman SJ editor. Hematopoietic Cell Transplantation. 2nd ed. Malden, MA: Blackwell; 1999;p. 176–185
  13. Brown JM. Fungal infections after hematopoietic cell transplantation. In:  Blume KG,  Forman SJ,  Appelbaum F editor. Thomas' Hematopoietic Cell Transplantation. 3rd ed. Malden, MA: Blackwell; 2004;p. 683–700
  14. Wingard JR. Bacterial infections. In:  Blume KG,  Forman SJ,  Appelbaum F editor. Thomas' Hematopoietic Cell Transplantation. 3rd ed. Malden, MA: Blackwell; 2004;p. 665–682
  15. Zaia JA. Cytomegalovirus infections. In:  Blume KG,  Forman SJ,  Appelbaum F editor. Thomas' Hematopoietic Cell Transplantation. 3rd ed. Malden, MA: Blackwell; 2004;p. 701–726
  16. Bellomo R, Ronco C, Kellum JA, et al. Acute renal failure: definition, outcome measures, animal models, fluid therapy and information technology needs. The Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit Care. 2004;8:R204–R212
  17. McDonald GB, Hinds MS, Fisher LD, et al. Veno-occlusive disease of the liver and multiorgan failure after bone marrow transplantation: a cohort study of 355 patients. Ann Intern Med. 1993;118:255–267
  18. Patzer L, Hempel L, Ringelmann F, et al. Renal function after conditioning therapy for bone marrow transplantation in childhood. Med Pediatr Oncol. 1997;28:274–283
  19. Patzer L, Ringelmann F, Kentouche K, et al. Renal function in long-term survivors of stem cell transplantation in childhood: a prospective trial. Bone Marrow Transplant. 2001;27:319–327
  20. Abbate M, Zoja C, Remuzzi G. How does proteinuria cause progressive renal damage?. J Am Soc Nephrol. 2006;17:2974–2984
  21. Biedermann BC, Sahner S, Gregor M, et al. Endothelial injury mediated by cytotoxic T lymphocytes and loss of microvessels in chronic graft-versus-host disease. Lancet. 2002;359:2078–2083
  22. Teshima T, Ordemann R, Reddy P, et al. Acute graft-versus-host disease does not require alloantigen expression on host epithelium. Nat Med. 2002;8:575–581
  23. Silva S, Maximino J, Henrique R, et al. Minimal change nephrotic syndrome after stem cell transplantation: a case report and literature review. J Med Case Rep. 2007;1:121
  24. Brukamp K, Doyle AM, Bloom RD, et al. Nephrotic syndrome after hematopoietic cell transplantation: do glomerular lesions represent renal graft-versus-host disease?. Clin J Am Soc Nephrol. 2006;1:685–694
  25. Seconi J, Watt V, Ritchie DS. Nephrotic syndrome following allogeneic stem cell transplantation associated with increased production of TNF-alpha and interferon-gamma by donor T cells. Bone Marrow Transplant. 2003;32:447–450
  26. Gerstein HC, Mann JF, Yi Q, et al. Albuminuria and risk of cardiovascular events, death, and heart failure in diabetic and nondiabetic individuals. JAMA. 2001;286:421–426
  27. Tuttle KR, Puhlman ME, Cooney SK, et al. Urinary albumin and insulin as predictors of coronary artery disease: an angiographic study. Am J Kidney Dis. 1999;34:918–925
  28. Barnett AH, Bain SC, Bouter P, et al. Angiotensin-receptor blockade versus converting-enzyme inhibition in type 2 diabetes and nephropathy. N Engl J Med. 2004;351:1952–1961
  29. Strippoli GF, Craig M, Deeks JJ, et al. Effects of angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists on mortality and renal outcomes in diabetic nephropathy: systematic review. BMJ. 2004;329:1–11
  30. Cohen EP, Irving AA, Drobyski WR, et al. Captopril to mitigate chronic renal failure after hematopoietic stem cell transplantation: a randomized controlled trial. Int J Radiat Oncol Biol Phys. 2008;70:1546–1551

 Financial disclosure: See Acknowledgments on page 1371.

PII: S1083-8791(08)00406-0

doi: 10.1016/j.bbmt.2008.09.015

Biology of Blood and Marrow Transplantation
Volume 14, Issue 12 , Pages 1365-1372 , December 2008

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