Biology of Blood and Marrow Transplantation
Volume 14, Issue 12 , Pages 1380-1384 , December 2008

Treatment Change as a Predictor of Outcome among Patients with Classic Chronic Graft-versus-Host Disease

  • Mary E.D. Flowers

      Affiliations

    • Division of Clinical Research, Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington
    • Department of Medicine, University of Washington School of Medicine, Seattle, Washington
    • Corresponding Author InformationCorrespondence and reprint requests: Mary E.D. Flowers, MD, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, D5-290, Seattle, WA 98109-1024.
    • ,
  • Barry Storer

      Affiliations

    • Division of Clinical Research, Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington
    • Department of Biostatistics, University of Washington School of Medicine, Seattle, Washington
    • ,
  • Paul Carpenter

      Affiliations

    • Division of Clinical Research, Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington
    • Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington
    • ,
  • Andrew R. Rezvani

      Affiliations

    • Division of Clinical Research, Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington
    • Department of Medicine, University of Washington School of Medicine, Seattle, Washington
    • ,
  • Afonso C. Vigorito

      Affiliations

    • Department of Bone Marrow Transplant Program at the UNICAMP, Campinas, Sao Paulo, Brasil
    • ,
  • Paulo V. Campregher

      Affiliations

    • Division of Clinical Research, Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington
    • ,
  • Carina Moravec

      Affiliations

    • Division of Clinical Research, Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington
    • ,
  • Hans-Peter Kiem

      Affiliations

    • Division of Clinical Research, Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington
    • Department of Medicine, University of Washington School of Medicine, Seattle, Washington
    • ,
  • Matthew Fero

      Affiliations

    • Division of Clinical Research, Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington
    • Department of Medicine, University of Washington School of Medicine, Seattle, Washington
    • ,
  • George Georges

      Affiliations

    • Division of Clinical Research, Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington
    • Department of Medicine, University of Washington School of Medicine, Seattle, Washington
    • ,
  • Edus Warren

      Affiliations

    • Division of Clinical Research, Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington
    • Department of Medicine, University of Washington School of Medicine, Seattle, Washington
    • ,
  • Stephanie Lee

      Affiliations

    • Division of Clinical Research, Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington
    • Department of Medicine, University of Washington School of Medicine, Seattle, Washington
    • ,
  • Jean E. Sanders

      Affiliations

    • Division of Clinical Research, Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington
    • Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington
    • ,
  • Fred Appelbaum

      Affiliations

    • Division of Clinical Research, Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington
    • Department of Medicine, University of Washington School of Medicine, Seattle, Washington
    • ,
  • Paul J. Martin

      Affiliations

    • Division of Clinical Research, Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington
    • Department of Medicine, University of Washington School of Medicine, Seattle, Washington

Received 28 August 2008 ,Accepted 19 September 2008.

  • Image Result

    Sites affected by cGVHD at time of diagnosis. Columns show the proportions of patients with organs affected by cGVHD at diagnosis.

    Sites affected by cGVHD at time of diagnosis. Columns show the proportions of patients with organs affected by cGVHD at diagnosis.

  • Image Result

    (A) Cumulative incidence of first change in treatment after initial systemic treatment for cGVHD. (B) Cumulative incidence of NRM after the initial diagnosis of cGVHD.

    (A) Cumulative incidence of first change in treatment after initial systemic treatment for cGVHD. (B) Cumulative incidence of NRM after the initial diagnosis of cGVHD.

  • Image Result

    The cumulative incidence of NRM was higher for patients who had a treatment change within 4 months after initial systemic treatment for cGVHD (solid line) than for those who did not have a treatment c

    The cumulative incidence of NRM was higher for patients who had a treatment change within 4 months after initial systemic treatment for cGVHD (solid line) than for those who did not have a treatment change during the first 4 months (dashed line).

 Financial disclosure: See Acknowledgments on page 1383.

PII: S1083-8791(08)00416-3

doi: 10.1016/j.bbmt.2008.09.017

Biology of Blood and Marrow Transplantation
Volume 14, Issue 12 , Pages 1380-1384 , December 2008

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