Biology of Blood and Marrow Transplantation
Volume 14, Issue 12 , Pages 1380-1384 , December 2008

Treatment Change as a Predictor of Outcome among Patients with Classic Chronic Graft-versus-Host Disease

  • Mary E.D. Flowers

      Affiliations

    • Division of Clinical Research, Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington
    • Department of Medicine, University of Washington School of Medicine, Seattle, Washington
    • Corresponding Author InformationCorrespondence and reprint requests: Mary E.D. Flowers, MD, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, D5-290, Seattle, WA 98109-1024.
    • ,
  • Barry Storer

      Affiliations

    • Division of Clinical Research, Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington
    • Department of Biostatistics, University of Washington School of Medicine, Seattle, Washington
    • ,
  • Paul Carpenter

      Affiliations

    • Division of Clinical Research, Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington
    • Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington
    • ,
  • Andrew R. Rezvani

      Affiliations

    • Division of Clinical Research, Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington
    • Department of Medicine, University of Washington School of Medicine, Seattle, Washington
    • ,
  • Afonso C. Vigorito

      Affiliations

    • Department of Bone Marrow Transplant Program at the UNICAMP, Campinas, Sao Paulo, Brasil
    • ,
  • Paulo V. Campregher

      Affiliations

    • Division of Clinical Research, Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington
    • ,
  • Carina Moravec

      Affiliations

    • Division of Clinical Research, Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington
    • ,
  • Hans-Peter Kiem

      Affiliations

    • Division of Clinical Research, Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington
    • Department of Medicine, University of Washington School of Medicine, Seattle, Washington
    • ,
  • Matthew Fero

      Affiliations

    • Division of Clinical Research, Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington
    • Department of Medicine, University of Washington School of Medicine, Seattle, Washington
    • ,
  • George Georges

      Affiliations

    • Division of Clinical Research, Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington
    • Department of Medicine, University of Washington School of Medicine, Seattle, Washington
    • ,
  • Edus Warren

      Affiliations

    • Division of Clinical Research, Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington
    • Department of Medicine, University of Washington School of Medicine, Seattle, Washington
    • ,
  • Stephanie Lee

      Affiliations

    • Division of Clinical Research, Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington
    • Department of Medicine, University of Washington School of Medicine, Seattle, Washington
    • ,
  • Jean E. Sanders

      Affiliations

    • Division of Clinical Research, Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington
    • Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington
    • ,
  • Fred Appelbaum

      Affiliations

    • Division of Clinical Research, Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington
    • Department of Medicine, University of Washington School of Medicine, Seattle, Washington
    • ,
  • Paul J. Martin

      Affiliations

    • Division of Clinical Research, Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington
    • Department of Medicine, University of Washington School of Medicine, Seattle, Washington

Received 28 August 2008 ,Accepted 19 September 2008.

References 

  1. Duell T, Van Lint MT, Ljungman P, et al. Health and functional status of long-term survivors of bone marrow transplantation. EBMT Working Party on Late Effects and EULEP Study Group on Late Effects. Ann Intern Med. 1997;126:184–192
  2. Socie G, Stone JV, Wingard JR, et al. Long-term survival and late deaths after allogeneic bone marrow transplantation. Late Effects Working Committee of the International Bone Marrow Transplant Registry. N Engl J Med. 1999;341:14–21
  3. Syrjala KL, Chapko MK, Vitaliano PP, Cummings C, Sullivan KM. Recovery after allogeneic marrow transplantation: prospective study of predictors of long-term physical and psychosocial functioning. Bone Marrow Transplant. 1993;11:319–327
  4. Goerner M, Gooley T, Flowers MED, et al. Morbidity and mortality of chronic GVHD after hematopoietic stem cell transplantation from HLA-identical siblings for patients with aplastic or refractory anemias. Biol Blood Marrow Transplant. 2002;8:47–56
  5. Lee SJ, Vogelsang G, Flowers MED. Chronic graft-versus-host disease. Biol Blood Marrow Transplant. 2003;9:215–233
  6. Storek J, Dawson MA, Storer B, et al. Immune reconstitution after allogeneic marrow transplantation compared with blood stem cell transplantation. Blood. 2001;97:3380–3389
  7. Stewart BL, Storer B, Storek J, et al. Duration of immunosuppressive treatment for chronic graft-versus-host disease. Blood. 2004;104:3501–3506
  8. Martin PJ. Study design and endpoints in graft-versus-host disease. Best Practice Res Clin Haematol. 2008;21:357–372
  9. Martin PJ, Weisdorf D, Przepiorka D, et al. National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: VI. Design of Clinical Trials Working Group report. Biol Blood Marrow Transplant. 2006;12:491–505
  10. Pavletic S, Martin P, Lee SJ, et al. Measuring therapeutic response in chronic graft-versus-host disease: National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: IV. Response Criteria Working Group report. Biol Blood Marrow Transplant. 2006;12:252–266
  11. Kim DH, Sohn SK, Baek JH, et al. Time to first flare-up episode of GVHD can stratify patients according to their prognosis during clinical course of progressive- or quiescent-type chronic GVHD. Bone Marrow Transplant. 2007;40:779–784
  12. Filipovich AH, Weisdorf D, Pavletic S, et al. National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. Diagnosis and Staging Working Group report. Biol Blood Marrow Transplant. 2005;11:945–956
  13. Gooley TA, Leisenring W, Crowley J, Storer BE. Estimation of failure probabilities in the presence of competing risks: new representations of old estimators. Stat Med. 1999;18:695–706
  14. Lee JH, Lee JH, Choi SJ, et al. Graft-versus-host disease (GVHD)-specific survival and duration of systemic immunosuppressive treatment in patients who developed chronic GVHD following allogeneic haematopoietic cell transplantation. Br J Haematol. 2003;122:637–644

 Financial disclosure: See Acknowledgments on page 1383.

PII: S1083-8791(08)00416-3

doi: 10.1016/j.bbmt.2008.09.017

Biology of Blood and Marrow Transplantation
Volume 14, Issue 12 , Pages 1380-1384 , December 2008

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