Biology of Blood and Marrow Transplantation
Volume 14, Issue 12 , Pages 1385-1393 , December 2008

Survival in a Recent Cohort of Mechanically Ventilated Pediatric Allogeneic Hematopoietic Stem Cell Transplantation Recipients

  • Josephus P.J. van Gestel

      Affiliations

    • Department of Pediatrics, Pediatric Intensive Care Unit, Subdivision of Pediatric Hematology, Utrecht, The Netherlands
    • Corresponding Author InformationCorrespondence and reprint requests: Josephus P.J. van Gestel, MD, Pediatric Intensive Care Unit, University Medical Center Utrecht, Wilhelmina Children's Hospital, P.O. Box 85090, 3508 AB Utrecht, The Netherlands.
    • ,
  • Casper W. Bollen

      Affiliations

    • Department of Pediatrics, Pediatric Intensive Care Unit, Subdivision of Pediatric Hematology, Utrecht, The Netherlands
    • ,
  • Marc B. Bierings

      Affiliations

    • Immunology and Bone Marrow Transplantation, University Medical Center Utrecht, Wilhelmina Children's Hospital, Utrecht, The Netherlands
    • ,
  • Jaap Jan Boelens

      Affiliations

    • Immunology and Bone Marrow Transplantation, University Medical Center Utrecht, Wilhelmina Children's Hospital, Utrecht, The Netherlands
    • ,
  • Nico M. Wulffraat

      Affiliations

    • Immunology and Bone Marrow Transplantation, University Medical Center Utrecht, Wilhelmina Children's Hospital, Utrecht, The Netherlands
    • ,
  • Adrianus J. van Vught

      Affiliations

    • Department of Pediatrics, Pediatric Intensive Care Unit, Subdivision of Pediatric Hematology, Utrecht, The Netherlands

Received 5 August 2008 ,Accepted 19 September 2008.

References 

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  2. van Gestel JPJ, Bollen CW, van der Tweel I, Boelens JJ, van Vught AJ. Intensive care unit mortality trends in children after hematopoietic stem cell transplantation: a meta-regression analysis. Crit Care Med. 2008;36:2898–2904
  3. Tamburro RF, Barfield RC, Shaffer ML, et al. Changes in outcomes (1996-2004) for pediatric oncology and hematopoietic stem cell transplant patients requiring invasive mechanical ventilation. Ped Crit Care Med. 2008;9:270–277
  4. Bratton SL, Van Duker H, Statler KD, Pulsipher MA, McArthur J, Keenan HT. Lower hospital mortality and complications after pediatric hematopoietic stem cell transplantation. Crit Care Med. 2008;36:923–927
  5. Warwick AB, Mertens AC, Shu XO, Ramsay NK, Neglia JP. Outcomes following mechanical ventilation in children undergoing bone marrow transplantation. Bone Marrow Transplant. 1998;22:787–794
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  7. Cheuk DK, Ha SY, Lee SL, Chan GC, Tsoi NS, Lau YL. Prognostic factors in children requiring admission to an intensive care unit after hematopoietic stem cell transplant. Hematol Oncol. 2004;22:1–9
  8. Diaz MA, Vicent MG, Prudencio M, et al. Predicting factors for admission to an intensive care unit and clinical outcome in pediatric patients receiving hematopoietic stem cell transplantation. Haematologica. 2002;87:292–298
  9. Pollack MM, Ruttimann UE, Getson PR. Pediatric risk of mortality (PRISM) score. Crit Care Med. 1988;16:1110–1116
  10. Glucksberg H, Storb R, Fefer A, et al. Clinical manifestations of graft-versus-host disease in human recipients of marrow from HL-A-matched sibling donors. Transplantation. 1974;18:295–304
  11. Jacobe SJ, Hassan A, Veys P. Outcome of children requiring admission to an intensive care unit after bone marrow transplantation. Crit Care Med. 2003;31:1299–1305
  12. Wilkinson JD, Pollack MM, Glass NL, Kanter RK, Katz RW, Steinhart CM. Mortality associated with multiple organ system failure and sepsis in pediatric intensive care unit. J Pediatr. 1987;111:324–328
  13. Tiercy JM. Molecular basis of HLA polymorphism: implications in clinical transplantation. Transpl Immunol. 2002;9:173–180
  14. Thiery G, Azoulay E, Darmon M, et al. Outcome of cancer patients considered for intensive care unit admission: a hospital-wide prospective study. J Clin Oncol. 2005;23:4406–4413
  15. Gonzalez-Vicent M, Marin C, Madero L, Sevilla J, Diaz MA. Risk score for pediatric intensive care unit admission in children undergoing hematopoietic stem cell transplantation and analysis of predictive factors for survival. J Pediatr Hematol Oncol. 2005;27:526–531
  16. Rossi R, Shemie SD, Calderwood S. Prognosis of pediatric bone marrow transplant recipients requiring mechanical ventilation. Crit Care Med. 1999;27:1181–1186
  17. Schneider DT, Lemburg P, Sprock I, Heying R, Gobel U, Nurnberger W. Introduction of the oncological pediatric risk of mortality score (O-PRISM) for ICU support following stem cell transplantation in children. Bone Marrow Transplant. 2000;25:1079–1086
  18. Henneveld HT, Wulffraat NM, Gemke RJ, van Vught AJ. Mechanical ventilation in bone marrow transplanted children; do they benefit?. Eur J Pediatr. 1998;157:441–442
  19. Bojko T, Notterman DA, Greenwald BM, De Bruin WJ, Magid MS, Godwin T. Acute hypoxemic respiratory failure in children following bone marrow transplantation: an outcome and pathologic study. Crit Care Med. 1995;23:755–759
  20. Tomaske M, Bosk A, Eyrich M, Bader P, Niethammer D. Risks of mortality in children admitted to the paediatric intensive care unit after hematopoietic stem cell transplantation. Br J Haematol. 2003;121:886–891
  21. Todd K, Wiley F, Landaw E, et al. Survival outcome among 54 intubated pediatric bone marrow transplant patients. Crit Care Med. 1994;22:171–176
  22. Hagen SA, Craig DM, Martin PL, et al. Mechanically ventilated pediatric stem cell transplant recipients: effect of cord blood transplant and organ dysfunction on outcome. Pediatr Crit Care Med. 2003;4:206–213
  23. Keenan HT, Bratton SL, Martin LD, Crawford SW, Weiss NS. Outcome of children who require mechanical ventilatory support after bone marrow transplantation. Crit Care Med. 2000;28:830–835

 Financial disclosure: See Acknowledgments on page 1392.

PII: S1083-8791(08)00419-9

doi: 10.1016/j.bbmt.2008.09.020

Biology of Blood and Marrow Transplantation
Volume 14, Issue 12 , Pages 1385-1393 , December 2008

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