Biology of Blood and Marrow Transplantation
Volume 14, Issue 12 , Pages 1408-1416 , December 2008

Vascular Endothelial Growth Factor Gene Polymorphisms May Predict the Risk of Acute Graft-versus-Host Disease following Allogeneic Transplantation: Preventive Effect of Vascular Endothelial Growth Factor Gene on Acute Graft-versus-Host Disease

  • Dong Hwan Kim

      Affiliations

    • Department of Hematology/Oncology, Kyungpook National University Hospital, Daegu, Korea
    • Department of Hematology/Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    • Corresponding Author InformationCorrespondence and reprint requests: Dong Hwan Kim, MD, PhD, Department of Hematology/Oncology, Samsung Medical Center, Irwon-dong 50, Kangnam-gu, Sungkyunkwan University School of Medicine, Seoul, Korea, 135-710.
    • ,
  • Nan Young Lee

      Affiliations

    • Department of Laboratory Medicine, Kyungpook National University Hospital, Daegu, Korea
    • ,
  • Myung-Hoon Lee

      Affiliations

    • Department of Biochemistry, Kyungpook National University Hospital, Daegu, Korea
    • ,
  • Sang Kyun Sohn

      Affiliations

    • Department of Hematology/Oncology, Kyungpook National University Hospital, Daegu, Korea

Received 18 May 2008 ,Accepted 24 September 2008.

  • Image Result

    Pairwise linkage disequilibrium in the study population. SNPs selected for haplotype are shown in bold.

    Pairwise linkage disequilibrium in the study population. SNPs selected for haplotype are shown in bold.

  • Image Result

    VEGFA genotype/haplotype and its association with the risk of aGVHD. Higher incidences of grade 2-4 aGVHD were observed in patients with the + 936 CT genotype (A) or the ACG haplotype for loci -2578/-

    VEGFA genotype/haplotype and its association with the risk of aGVHD. Higher incidences of grade 2-4 aGVHD were observed in patients with the + 936 CT genotype (A) or the ACG haplotype for loci -2578/-460/+405 (B).

  • Image Result
    VEGFA risk score model and its association with the risk of aGVHD. Patients with a VEGFA risk score of 1 or 2 had higher incidences of aGVHD grade 1-4 (A) or grade 2-4 (B) than those with a VEGFA risk

    VEGFA risk score model and its association with the risk of aGVHD. Patients with a VEGFA risk score of 1 or 2 had higher incidences of aGVHD grade 1-4 (A) or grade 2-4 (B) than those with a VEGFA risk score of 0.

  • Image Result
    Associations between VEGFA genotypes with the risk of gut GVHD. The VEGFA -2578C>A (A) and -460T>C genotypes (B) were found to be associated with the risk of gut GVHD.

    Associations between VEGFA genotypes with the risk of gut GVHD. The VEGFA -2578C>A (A) and -460T>C genotypes (B) were found to be associated with the risk of gut GVHD.

 Financial disclosure: See Acknowledgments on page 1415.

 Presented at the European School of Hematology Euroconference on Translational Research in Transplantation, Integrating Immunity: From Genomics to Cell Therapy, Leiden, The Netherlands, November 2007.

PII: S1083-8791(08)00421-7

doi: 10.1016/j.bbmt.2008.09.022

Biology of Blood and Marrow Transplantation
Volume 14, Issue 12 , Pages 1408-1416 , December 2008

Article Tools

* Image Usage & Resolution