Biology of Blood and Marrow Transplantation
Volume 14, Issue 12 , Pages 1408-1416 , December 2008

Vascular Endothelial Growth Factor Gene Polymorphisms May Predict the Risk of Acute Graft-versus-Host Disease following Allogeneic Transplantation: Preventive Effect of Vascular Endothelial Growth Factor Gene on Acute Graft-versus-Host Disease

  • Dong Hwan Kim

      Affiliations

    • Department of Hematology/Oncology, Kyungpook National University Hospital, Daegu, Korea
    • Department of Hematology/Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    • Corresponding Author InformationCorrespondence and reprint requests: Dong Hwan Kim, MD, PhD, Department of Hematology/Oncology, Samsung Medical Center, Irwon-dong 50, Kangnam-gu, Sungkyunkwan University School of Medicine, Seoul, Korea, 135-710.
    • ,
  • Nan Young Lee

      Affiliations

    • Department of Laboratory Medicine, Kyungpook National University Hospital, Daegu, Korea
    • ,
  • Myung-Hoon Lee

      Affiliations

    • Department of Biochemistry, Kyungpook National University Hospital, Daegu, Korea
    • ,
  • Sang Kyun Sohn

      Affiliations

    • Department of Hematology/Oncology, Kyungpook National University Hospital, Daegu, Korea

Received 18 May 2008 ,Accepted 24 September 2008.

Reference 

  1. Biedermann BC, Sahner S, Gregor M, et al. Endothelial injury mediated by cytotoxic T lymphocytes and loss of microvessels in chronic graft versus host disease. Lancet. 2002;359:2078–2083
  2. Thomas KA. Vascular endothelial growth factor, a potent and selective angiogenic agent. The Journal of biological chemistry. 1996;271:603–606
  3. Klagsbrun M, D'Amore PA. Vascular endothelial growth factor and its receptors. Cytokine & growth factor reviews. 1996;7:259–270
  4. Min CK, Kim SY, Lee MJ, et al. Vascular endothelial growth factor (VEGF) is associated with reduced severity of acute graft-versus-host disease and nonrelapse mortality after allogeneic stem cell transplantation. Bone marrow transplantation. 2006;38:149–156
  5. Wen FQ, Liu X, Manda W, et al. TH2 Cytokine-enhanced and TGF-beta-enhanced vascular endothelial growth factor production by cultured human airway smooth muscle cells is attenuated by IFN-gamma and corticosteroids. The Journal of allergy and clinical immunology. 2003;111:1307–1318
  6. Nachbaur D, Schumacher P, Auberger J, Clausen J, Kircher B. Vascular endothelial growth factor and activin-a serum levels following allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2007;13:942–947
  7. Tischer E, Mitchell R, Hartman T, et al. The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing. The Journal of biological chemistry. 1991;266:11947–11954
  8. Vincenti V, Cassano C, Rocchi M, Persico G. Assignment of the vascular endothelial growth factor gene to human chromosome 6p21.3. Circulation. 1996;93:1493–1495
  9. Brogan IJ, Khan N, Isaac K, Hutchinson JA, Pravica V, Hutchinson IV. Novel polymorphisms in the promoter and 5' UTR regions of the human vascular endothelial growth factor gene. Human immunology. 1999;60:1245–1249
  10. Renner W, Kotschan S, Hoffmann C, Obermayer-Pietsch B, Pilger E. A common 936 C/T mutation in the gene for vascular endothelial growth factor is associated with vascular endothelial growth factor plasma levels. Journal of vascular research. 2000;37:443–448
  11. Watson CJ, Webb NJ, Bottomley MJ, Brenchley PE. Identification of polymorphisms within the vascular endothelial growth factor (VEGF) gene: correlation with variation in VEGF protein production. Cytokine. 2000;12:1232–1235
  12. Stevens A, Soden J, Brenchley PE, Ralph S, Ray DW. Haplotype analysis of the polymorphic human vascular endothelial growth factor gene promoter. Cancer research. 2003;63:812–816
  13. Koukourakis MI, Papazoglou D, Giatromanolaki A, Bougioukas G, Maltezos E, Sivridis E. VEGF gene sequence variation defines VEGF gene expression status and angiogenic activity in non-small cell lung cancer. Lung cancer (Amsterdam, Netherlands). 2004;46:293–298
  14. Prior SJ, Hagberg JM, Paton CM, et al. DNA sequence variation in the promoter region of the VEGF gene impacts VEGF gene expression and maximal oxygen consumption. American journal of physiology. 2006;290:H1848–H1855
  15. Kim DH, Lee NY, Sohn SK, et al. IL-10 promoter gene polymorphism associated with the occurrence of chronic GVHD and its clinical course during systemic immunosuppressive treatment for chronic GVHD after allogeneic peripheral blood stem cell transplantation. Transplantation. 2005;79:1615–1622
  16. Kim DH, Sohn SK, Baek JH, et al. Time to first flare-up episode of GVHD can stratify patients according to their prognosis during clinical course of progressive- or quiescent-type chronic GVHD. Bone marrow transplantation. 2007;40:779–784
  17. Lee SJ, Lee SY, Jeon HS, et al. Vascular endothelial growth factor gene polymorphisms and risk of primary lung cancer. Cancer Epidemiol Biomarkers Prev. 2005;14:571–575
  18. Nam EJ, Han SW, Kim SU, et al. Association of vascular endothelial growth factor gene polymorphisms with behcet disease in a Korean population. Hum Immunol. 2005;66:1068–1073
  19. Han SW, Kim GW, Seo JS, et al. VEGF gene polymorphisms and susceptibility to rheumatoid arthritis. Rheumatology (Oxford). 2004;43:1173–1177
  20. Kim DH, Lee NY, Lee MH, Sohn SK, Do YR, Park JY. Vascular endothelial growth factor (VEGF) gene (VEGFA) polymorphism can predict the prognosis in acute myeloid leukaemia patients. British journal of haematology. 2008;140:71–79
  21. Stephens M, Smith NJ, Donnelly P. A new statistical method for haplotype reconstruction from population data. American journal of human genetics. 2001;68:978–989
  22. Przepiorka D, Weisdorf D, Martin P, et al. 1994 Consensus Conference on Acute GVHD Grading. Bone marrow transplantation. 1995;15:825–828
  23. Shulman HM, Sale GE, Lerner KG, et al. Chronic cutaneous graft-versus-host disease in man. The American journal of pathology. 1978;91:545–570
  24. Scrucca L, Santucci A, Aversa F. Competing risk analysis using R: an easy guide for clinicians. Bone marrow transplantation. 2007;40:381–387
  25. Angelo LS, Kurzrock R. Vascular endothelial growth factor and its relationship to inflammatory mediators. Clin Cancer Res. 2007;13:2825–2830
  26. Dvorak HF, Detmar M, Claffey KP, Nagy JA, van de Water L, Senger DR. Vascular permeability factor/vascular endothelial growth factor: an important mediator of angiogenesis in malignancy and inflammation. International archives of allergy and immunology. 1995;107:233–235
  27. Reinders ME, Sho M, Izawa A, et al. Proinflammatory functions of vascular endothelial growth factor in alloimmunity. J Clin Invest. 2003;112:1655–1665
  28. Kanazawa S, Tsunoda T, Onuma E, Majima T, Kagiyama M, Kikuchi K. VEGF, basic-FGF, and TGF-beta in Crohn's disease and ulcerative colitis: a novel mechanism of chronic intestinal inflammation. The American journal of gastroenterology. 2001;96:822–828
  29. Kapsoritakis A, Sfiridaki A, Maltezos E, et al. Vascular endothelial growth factor in inflammatory bowel disease. International journal of colorectal disease. 2003;18:418–422
  30. Danese S, Sans M, de la Motte C, et al. Angiogenesis as a novel component of inflammatory bowel disease pathogenesis. Gastroenterology. 2006;130:2060–2073
  31. Dickinson AM, Middleton PG, Rocha V, Gluckman E, Holler E. Genetic polymorphisms predicting the outcome of bone marrow transplants. Br J Haematol. 2004;127:479–490
  32. Kallianpur AR. Genomic screening and complications of hematopoietic stem cell transplantation: has the time come?. Bone Marrow Transplant. 2005;35:1–16
  33. Dickinson AM, Middleton PG. Beyond the HLA typing age: genetic polymorphisms predicting transplant outcome. Blood Rev. 2005;19:333–340
  34. Krippl P, Langsenlehner U, Renner W, et al. A common 936 C/T gene polymorphism of vascular endothelial growth factor is associated with decreased breast cancer risk. Int J Cancer. 2003;106:468–471

 Financial disclosure: See Acknowledgments on page 1415.

 Presented at the European School of Hematology Euroconference on Translational Research in Transplantation, Integrating Immunity: From Genomics to Cell Therapy, Leiden, The Netherlands, November 2007.

PII: S1083-8791(08)00421-7

doi: 10.1016/j.bbmt.2008.09.022

Biology of Blood and Marrow Transplantation
Volume 14, Issue 12 , Pages 1408-1416 , December 2008

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