Biology of Blood and Marrow Transplantation
Volume 15, Issue 1, Supplement , Pages 33-38, January 2009

Plasma Biomarkers in Graft-versus-Host Disease: A New Era?

  • Sophie Paczesny

      Affiliations

    • Department of Pediatrics, University of Michigan, Ann Arbor, Michigan
    • Corresponding Author InformationCorrespondence and reprint requests: Sophie Paczesny, MD, PhD, University of Michigan Comprehensive Cancer Center 6420,1500 E Medical Center Dr. Ann Arbor, MI 48109-5942, Ph# 734-615-3342, Fax# 734-615-3947.
    • ,
  • John E. Levine

      Affiliations

    • Department of Pediatrics, University of Michigan, Ann Arbor, Michigan
    • Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan
    • ,
  • Thomas M. Braun

      Affiliations

    • Department of Biostatistics, University of Michigan, Ann Arbor, Michigan
    • ,
  • James L.M. Ferrara

      Affiliations

    • Department of Pediatrics, University of Michigan, Ann Arbor, Michigan
    • Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan

Acute graft versus host disease (GVHD) remains a major complication of allogeneic hematopoietic cell transplantation (HCT). The diagnosis of acute GVHD is based on strictly clinical criteria and its severity also determined by these criteria. Currently, there is no validated diagnostic blood test for acute GVHD. This review will summarize proteomics approaches to identify biomarkers for GVHD in the plasma with diagnostic, prognostic and predictive value. If successful, these studies could establish a novel biomarker panel that will contribute important information including long term survival, and that may eventually facilitate therapeutic decisions for allogeneic HCT patients.

Key Words: Graft versus host disease, proteomics, plasma biomarker, biomarkers panel

 

 Financial disclosure: See Acknowledgments on page 37.

PII: S1083-8791(08)00475-8

doi:10.1016/j.bbmt.2008.10.027

Biology of Blood and Marrow Transplantation
Volume 15, Issue 1, Supplement , Pages 33-38, January 2009

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