Biology of Blood and Marrow Transplantation
Volume 15, Issue 7 , Pages 795-803 , July 2009

Allogeneic Hematopoietic Stem Cell Transplantation Recipients Have Defects of Both Switched and IgM Memory B Cells

  • Lloyd J. D'Orsogna

      Affiliations

    • Department of Clinical Immunology and Immunogenetics, Royal Perth Hospital and PathWest Laboratory Medicine, Perth, Australia
    • ,
  • Matthew P. Wright

      Affiliations

    • Department of Haematology, Royal Perth Hospital and PathWest Laboratory Medicine, Perth, Australia
    • ,
  • Rom G. Krueger

      Affiliations

    • Flow Cytometry Unit, Royal Perth Hospital and PathWest Laboratory Medicine, Perth, Australia
    • ,
  • Elizabeth J. McKinnon

      Affiliations

    • Centre for Clinical Immunology and Biomedical Statistics, Murdoch University and Royal Perth Hospital, Perth, Australia
    • ,
  • Susan I. Buffery

      Affiliations

    • Department of Haematology, Royal Perth Hospital and PathWest Laboratory Medicine, Perth, Australia
    • ,
  • Campbell S. Witt

      Affiliations

    • Department of Clinical Immunology and Immunogenetics, Royal Perth Hospital and PathWest Laboratory Medicine, Perth, Australia
    • School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia
    • ,
  • Nicole Staples

      Affiliations

    • Department of Haematology, Royal Perth Hospital and PathWest Laboratory Medicine, Perth, Australia
    • ,
  • Richard Loh

      Affiliations

    • Department of Clinical Immunology, Princess Margaret Hospital for Children and PathWest Laboratory Medicine, Perth, Australia
    • ,
  • Paul K. Cannell

      Affiliations

    • Department of Haematology, Royal Perth Hospital and PathWest Laboratory Medicine, Perth, Australia
    • ,
  • Frank T. Christiansen

      Affiliations

    • Department of Clinical Immunology and Immunogenetics, Royal Perth Hospital and PathWest Laboratory Medicine, Perth, Australia
    • School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia
    • ,
  • Martyn A. French

      Affiliations

    • Department of Clinical Immunology and Immunogenetics, Royal Perth Hospital and PathWest Laboratory Medicine, Perth, Australia
    • School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia
    • Corresponding Author InformationCorrespondence and reprint requests: Professor Martyn French, Department of Clinical Immunology and Immunogenetics, Royal Perth Hospital, P.O. Box X2213, Perth, WA 6847, Australia.

Received 13 November 2008 ,Accepted 5 February 2009.

  • Image Result

    Allogeneic HSCT patients (n = 37) are deficient of total, IgM, and switched memory B cells when compared with controls (n = 35). The plots indicate the median (thick line), interquartile range (box),

    Allogeneic HSCT patients (n = 37) are deficient of total, IgM, and switched memory B cells when compared with controls (n = 35). The plots indicate the median (thick line), interquartile range (box), and range (whiskers) of the respective data samples.

  • Image Result
    Switched memory B cells correlate strongly with serum levels of total IgG and IgG1 (P < .0001) in allogeneic HSCT patients.

    Switched memory B cells correlate strongly with serum levels of total IgG and IgG1 (P < .0001) in allogeneic HSCT patients.

  • Image Result
    Memory B cell and IgG deficiency correlates with the CD4 T cell deficiency.

    Memory B cell and IgG deficiency correlates with the CD4 T cell deficiency.

  • Image Result
    Serum levels of IgA, IgG, and IgG subclasses are lower in allogeneic HSCT patients with GVHD.

    Serum levels of IgA, IgG, and IgG subclasses are lower in allogeneic HSCT patients with GVHD.

PII: S1083-8791(08)00578-8

doi: 10.1016/j.bbmt.2008.11.024

Biology of Blood and Marrow Transplantation
Volume 15, Issue 7 , Pages 795-803 , July 2009

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