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Biology of Blood and Marrow Transplantation
Volume 15, Issue 4
, Pages 496-504
, April 2009
Immune Reconstitution following Myeloablative Allogeneic Hematopoietic Stem Cell Transplantation: The Impact of Expanding CD28negative CD8+ T Cells on Relapse
References
- . Molecules and mechanisms of the graft-versus-leukaemia effect. Nat Rev Cancer. 2004;4:371–380
- . Graft-versus-host disease. Nat Rev Immunol. 2007;7:340–352
- Distinctions between CD8+ and CD4+ T-cell regenerative pathways result in prolonged T-cell subset imbalance after intensive chemotherapy. Blood. 1997;89:3700–3707
- Immunity of patients surviving 20 to 30 years after allogeneic or syngeneic bone marrow transplantation. Blood. 2001;98:3505–3512
- Reconstitution of lymphocyte subpopulations after paediatric bone marrow transplantation. Bone Marrow Transplant. 2000;25:267–275
- . Immune reconstitution following haematopoietic stem cell transplantation. Br J Haematol. 2004;124:407–420
- . T cell immune reconstitution following lymphodepletion. Semin Immunol. 2007;19:318–330
- . The molecular program induced in T cells undergoing homeostatic proliferation. Proc Natl Acad Sci USA. 2004;101:16885–16890
- . Central memory and effector memory T cell subsets: function, generation, and maintenance. Annu Rev Immunol. 2004;22:745–763
- . Human CD8+ T-cell differentiation in response to viruses. Nat Rev Immunol. 2003;3:931–939
- Four functionally distinct populations of human effector-memory CD8+ T lymphocytes. J Immunol. 2007;178:4112–4119
- A high proportion of donor CD4+ T cells expressing the lymph node-homing chemokine receptor CCR7 increases incidence and severity of acute graft-versus-host disease in patients undergoing allogeneic stem cell transplantation for hematologic malignancy. Leukemia. 2006;20:1557–1565
- Comparative analysis of naive and memory CD4+ and CD8+ T-cell subsets in bone marrow and G-CSF-mobilized peripheral blood stem cell allografts: impact of donor characteristics. Exp Hematol. 2007;35:861–871
- Quantitative assessment of hematopoietic chimerism after bone marrow transplantation by real-time quantitative polymerase chain reaction. Blood. 2002;99:4618–4625
- Accumulation of memory T cells from childhood to old age: central and effector memory cells in CD4+ versus effector memory and terminally differentiated memory cells in CD8+ compartment. Mech Ageing Dev. 2006;127:274–281
- . Cumulative incidence in competing risks data and competing risks regression analysis. Clin Cancer Res. 2007;13:559–565
- Immune reconstitution to cytomegalovirus after allogeneic hematopoietic stem cell transplantation: impact of host factors, drug therapy, and subclinical reactivation. Blood. 2003;102:3060–3067
- Immune reconstitution after allogeneic marrow transplantation compared with blood stem cell transplantation. Blood. 2001;97:3380–3389
- . Loss of CD28 expression on CD8+ T cells is induced by IL-2 receptor gamma chain signalling cytokines and type I IFN, and increases susceptibility to activation-induced apoptosis. Int Immunol. 2000;12:1005–1013
- . Generation and growth of CD28nullCD8+ memory T cells mediated by IL-15 and its induced cytokines. J Immunol. 2006;177:7802–7810
- T-cell dynamics after high-dose chemotherapy in adults: elucidation of the elusive CD8+ subset reveals multiple homeostatic T-cell compartments with distinct implications for immune competence. Immunology. 2002;106:27–37
- Homeostatic repopulation by CD28−CD8+ T cells in alemtuzumab-depleted kidney transplant recipients treated with reduced immunosuppression. Am J Transplant. 2008;8:338–347
- . Immune reconstitution after allogeneic stem cell transplantation: the impact of stem cell source and graft-versus-host disease. Haematologica. 2005;90:86–93
- Unrelated donor status and high donor age independently affect immunologic recovery after nonmyeloablative conditioning. Biol Blood Marrow Transplant. 2006;12:1176–1187
- . Early lymphocyte recovery post-allogeneic hematopoietic stem cell transplantation is associated with significant graft-versus-leukemia effect without increase in graft-versus-host disease in pediatric acute lymphoblastic leukemia. Bone Marrow Transplant. 2008;41:245–252
- Severe chronic graft-versus-host disease is characterized by a preponderance of CD4+ effector memory cells relative to central memory cells. Blood. 2004;103:3986–3988
- . Altered homeostasis of CD4+ memory T cells in allogeneic hematopoietic stem cell transplant recipients: chronic graft-versus-host disease enhances T cell differentiation and exhausts central memory T cell pool. Biol Blood Marrow Transplant. 2007;13:1176–1184
- Unique abnormalities of CD4+ and CD8+ central memory cells associated with chronic graft-versus-host disease improve after extracorporeal photopheresis. Biol Blood Marrow Transplant. 2006;12:22–30
- . Increase of CCR7− CD45RA+ CD8 T cells (TEMRA) in chronic graft-versus-host disease. Leukemia. 2006;20:545–547
- Marked increase of CD8+S6F1+ and CD8+CD57+ cells in patients with graft-versus-host disease after allogeneic bone marrow transplantation. Bone Marrow Transplant. 1994;13:181–185
- . Immuno-monitoring of CD8+ T cells in whole blood versus PBMC samples. J Immunol Methods. 2006;309:192–199
- . The new paradigm of T-cell homeostatic proliferation-induced autoimmunity. Trends Immunol. 2005;26:5–8
- Molecular analysis of alloreactive CTL post-hemopoietic stem cell transplantation. J Immunol. 2007;179:2013–2022
- Efficient identification of T-cell clones associated with graft-versus-host disease in target tissue allows for subsequent detection in peripheral blood. Br J Haematol. 2005;129:411–419
- . Expansion of CD8+CD57+ T cells after allogeneic BMT is related with a low incidence of relapse and with cytomegalovirus infection. Br J Haematol. 1995;90:300–730
- The combined effect of total body irradiation (TBI) and cyclosporin A (CyA) on the risk of relapse in patients with acute myeloid leukaemia undergoing allogeneic bone marrow transplantation. Br J Haematol. 2000;108:99–104
The first 2 authors contributed equally to this work and should be considered as first authors.
Financial disclosure: See Acknowledgments on page 503.
PII: S1083-8791(08)00588-0
doi: 10.1016/j.bbmt.2008.11.038
© 2009 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.
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Biology of Blood and Marrow Transplantation
Volume 15, Issue 4
, Pages 496-504
, April 2009
