Risk Factors Affecting Outcome of Second HLA-Matched Sibling Donor Transplantations for Graft Failure in Severe Acquired Aplastic Anemia

Cumulative incidence of neutrophil and platelet recovery after second HLA-matched sibling donor transplantation for graft failure.

Overall survival after second HLA-matched sibling donor transplantation for graft failure in SAA by time between first to second transplantation and Karnofsky performance score. Eight-year probability of overall survival in patients with a performance score of 90 to 100 and an intertransplantation interval > 3 months (…… ; 76% [95% CI = 62% to 88%]); in patients with a performance score < 90 and an intertransplantation interval > 3 months (– – – –; 61% [95% CI = 50% to 72%]); in patients with a performance score of 90 to 100 and an intertransplantation interval < 3 months (- - - - -; 56% [95% CI = 24% to 85&]); and in patients with a performance score < 90 and an intertransplantation interval < 3 months (———; 33% [95% CI = 19% to 49%]).