Biology of Blood and Marrow Transplantation
Volume 15, Issue 5 , Pages 626-631 , May 2009

Risk Factors Affecting Outcome of Second HLA-Matched Sibling Donor Transplantations for Graft Failure in Severe Acquired Aplastic Anemia

  • John T. Horan

      Affiliations

    • Blood and Marrow Transplant Program, Emory University (Department of Pediatrics)/Children's Healthcare of Atlanta, Atlanta, Georgia
    • Corresponding Author InformationCorrespondence and reprint requests: John T. Horan, MD, MPH, Emory University/Children's Healthcare of Atlanta, Blood and Marrow Transplant Program, 1405 Clifton Road NE, Atlanta, GA 30322.
    • ,
  • Jeanette Carreras

      Affiliations

    • Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin
    • ,
  • Sergey Tarima

      Affiliations

    • Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin
    • ,
  • Bruce M. Camitta

      Affiliations

    • Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin
    • ,
  • Robert Peter Gale

      Affiliations

    • Celgene Corporation, Summit, New Jersey
    • ,
  • Gregory A. Hale

      Affiliations

    • St. Jude Children's Research Hospital, Memphis, Tennessee
    • ,
  • Wolfgang Hinterberger

      Affiliations

    • Ludwig Boltzmann Institute, Wien, Austria
    • ,
  • Judith Marsh

      Affiliations

    • King's College Hospital, London, UK
    • ,
  • Jakob R. Passweg

      Affiliations

    • Geneva University Hospital, Geneva, Switzerland
    • ,
  • Mark C. Walters

      Affiliations

    • Children's Hospital and Research Center, Oakland, California
    • ,
  • Mary Eapen

      Affiliations

    • Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin

Received 30 October 2008 ,Accepted 31 January 2009.

References 

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  2. Bacigalupo A, Brand R, Oneto R, et al. Treatment of acquired severe aplastic anemia: bone marrow transplantation compared with immunosuppressive therapy: the European Group for Blood and Marrow Transplantation experience. Semin Hematol. 2000;37:69–80
  3. Fuhrer M, Rampf U, Baumann I, et al. Immunosuppressive therapy for aplastic anemia in children: a more severe disease predicts better survival. Blood. 2005;106:2102–2104
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  11. Gooley TA, Leisenring W, Crowley J, et al. Estimation of failure probabilities in the presence of competing risks: new representations of old estimators. Stat Med. 1999;18:695–706
  12. Klein J, Moeschberger M. Survival Analysis: Techniques of Censored and Truncated Data. New York: Springer-Verlag; 2003;
  13. Klein JP, Andersen PK. Regression modeling of competing risks data based on pseudovalues of the cumulative incidence function. Biometrics. 2005;61:223–229
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  15. de Medeiros CR, Bitencourt MA, Medeiros BC, et al. Second bone marrow transplantation for severe aplastic anemia: analysis of 34 cases. Bone Marrow Transplant. 2001;28:941–944
  16. Schrezenmeier H, Passweg JR, Marsh JC, et al. Worse outcome and more chronic GVHD with peripheral blood progenitor cells than bone marrow in HLA-matched sibling donor transplants for young patients with severe acquired aplastic anemia. Blood. 2007;110:1397–1400
  17. Bhatia S, Francisco L, Carter A, et al. Late mortality after allogeneic hematopoietic cell transplantation and functional status of long-term survivors: report from the Bone Marrow Transplant Survivor Study. Blood. 2007;110:3784–3792
  18. Fraser CJ, Bhatia S, Ness K, et al. Impact of chronic graft-versus-host disease on the health status of hematopoietic cell transplantation survivors: a report from the Bone Marrow Transplant Survivor Study. Blood. 2006;108:2867–2873

 Financial disclosure: See Acknowledgments on page 630.

PII: S1083-8791(09)00075-5

doi: 10.1016/j.bbmt.2009.01.023

Biology of Blood and Marrow Transplantation
Volume 15, Issue 5 , Pages 626-631 , May 2009

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