Biology of Blood and Marrow Transplantation
Volume 15, Issue 8 , Pages 956-962 , August 2009

Clinical Significance of Serum Hepcidin Levels on Early Infectious Complications in Allogeneic Hematopoietic Stem Cell Transplantation

  • Junya Kanda

      Affiliations

    • Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    • Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    • Corresponding Author InformationCorrespondence and reprint requests: Junya Kanda, MD, Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan.
    • ,
  • Chisaki Mizumoto

      Affiliations

    • Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    • ,
  • Hiroshi Kawabata

      Affiliations

    • Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    • ,
  • Tatsuo Ichinohe

      Affiliations

    • Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    • ,
  • Hideyuki Tsuchida

      Affiliations

    • Proteomics Research Unit, Division of Advanced Medicine, Medical Research Institute, Kanazawa Medical University, Ishikawa, Japan
    • ,
  • Naohisa Tomosugi

      Affiliations

    • Proteomics Research Unit, Division of Advanced Medicine, Medical Research Institute, Kanazawa Medical University, Ishikawa, Japan
    • ,
  • Keitaro Matsuo

      Affiliations

    • Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    • Department of Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    • ,
  • Kouhei Yamashita

      Affiliations

    • Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    • ,
  • Tadakazu Kondo

      Affiliations

    • Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    • ,
  • Takayuki Ishikawa

      Affiliations

    • Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    • ,
  • Takashi Uchiyama

      Affiliations

    • Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

Received 27 February 2009 ,Accepted 13 April 2009.

  • Image Result

    The cumulative incidences of documented bacterial infection (A) and cytomegalovirus (CMV) infection (B) at 100 days after stem cell transplantation. Solid black line, the low-hepcidin group (<50 ng/mL

    The cumulative incidences of documented bacterial infection (A) and cytomegalovirus (CMV) infection (B) at 100 days after stem cell transplantation. Solid black line, the low-hepcidin group (<50 ng/mL); solid gray line, the high-hepcidin group (≥50 ng/mL); CI, confidence interval. CMV infection was not assessable in 2 patients because of early death before neutrophil engraftment.

  • Image Result
    Kaplan-Meier estimate of OS at 100 days after stem cell transplantation. Solid black line, the low-hepcidin group (<50 ng/mL); solid gray line, the high-hepcidin group (≥50 ng/mL); CI, confidence inte

    Kaplan-Meier estimate of OS at 100 days after stem cell transplantation. Solid black line, the low-hepcidin group (<50 ng/mL); solid gray line, the high-hepcidin group (≥50 ng/mL); CI, confidence interval.

 Financial disclosure: See Acknowledgments on page 961.

PII: S1083-8791(09)00210-9

doi: 10.1016/j.bbmt.2009.04.008

Biology of Blood and Marrow Transplantation
Volume 15, Issue 8 , Pages 956-962 , August 2009

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