Biology of Blood and Marrow Transplantation
Volume 15, Issue 9 , Pages 1134-1139 , September 2009

Pharmacokinetics of Mycophenolic Acid Administered 3 Times Daily after Hematopoietic Stem Cell Transplantation with Reduced-Intensity Regimen

  • Bernard Royer

      Affiliations

    • Inserm, U645, Besançon, France; Université de Franche-Comté, Besançon, France; EFS, BFC, Besançon, France
    • CHU Besançon, Laboratoire de Pharmacologie Clinique, Hôpital Jean Minjoz, Besançon, France
    • ,
  • Fabrice Larosa

      Affiliations

    • CHU Besançon, Service d'Hématologie, Hôpital Jean Minjoz, Besançon, France
    • ,
  • Faezeh Legrand

      Affiliations

    • CHU Besançon, Service d'Hématologie, Hôpital Jean Minjoz, Besançon, France
    • ,
  • Pauline Gerritsen-van Schieveen

      Affiliations

    • CHU Besançon, Laboratoire de Pharmacologie Clinique, Hôpital Jean Minjoz, Besançon, France
    • ,
  • Michel Bérard

      Affiliations

    • CHU Besançon, Laboratoire de Pharmacologie Clinique, Hôpital Jean Minjoz, Besançon, France
    • ,
  • Jean-Pierre Kantelip

      Affiliations

    • CHU Besançon, Laboratoire de Pharmacologie Clinique, Hôpital Jean Minjoz, Besançon, France
    • ,
  • Eric Deconinck

      Affiliations

    • Inserm, U645, Besançon, France; Université de Franche-Comté, Besançon, France; EFS, BFC, Besançon, France
    • CHU Besançon, Service d'Hématologie, Hôpital Jean Minjoz, Besançon, France
    • Corresponding Author InformationCorrespondence to: Eric Deconinck, MD, PhD, CHU Besançon, Service d'Hématologie, Hôpital Jean Minjoz, bvd Fleming, 25030 Besançon, France.

Received 25 February 2009 ,Accepted 18 April 2009.

  • Image Result

    Mean concentration-time profiles of MPA for samples obtained at D0 (A), D7 (B), and M1 (C) after the beginning of MMF treatment. The results are the mean±SD of 13 to15 patients.

    Mean concentration-time profiles of MPA for samples obtained at D0 (A), D7 (B), and M1 (C) after the beginning of MMF treatment. The results are the mean±SD of 13 to15 patients.

  • Image Result

    Normalized AUC0-8 obtained at D0 during the first (D0 PK1) and the second administration (D0 PK2), at D7 during the first (D7 PK1) and the second administration (D7 PK2), and at M1. The box represents

    Normalized AUC0-8 obtained at D0 during the first (D0 PK1) and the second administration (D0 PK2), at D7 during the first (D7 PK1) and the second administration (D7 PK2), and at M1. The box represents the 25th and 75th percentiles with the median as a solid line, and the whiskers the 5th/95th percentiles.

  • Image Result
    Actual values of AUC0-8 obtained in patients with aGHVD ≥2 (black dots) and patients with aGVHD <2 (open circles).

    Actual values of AUC0-8 obtained in patients with aGHVD ≥2 (black dots) and patients with aGVHD <2 (open circles).

 Financial disclosure: See Acknowledgments on page 1138.

PII: S1083-8791(09)00213-4

doi: 10.1016/j.bbmt.2009.04.011

Biology of Blood and Marrow Transplantation
Volume 15, Issue 9 , Pages 1134-1139 , September 2009

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