Biology of Blood and Marrow Transplantation
Volume 15, Issue 8 , Pages 971-981 , August 2009

HLA-A Disparities Illustrate Challenges for Ranking the Impact of HLA Mismatches on Bone Marrow Transplant Outcomes in the United States

  • Lee Ann Baxter-Lowe

      Affiliations

    • University of California San Francisco, San Francisco, California
    • Corresponding Author InformationCorrespondence and reprint requests: Lee Ann Baxter-Lowe, PhD, University of California San Francisco, Box 0508, San Francisco, CA 94143-0508.
    • ,
  • Martin Maiers

      Affiliations

    • National Marrow Donor Program, Minneapolis, Minneapolis
    • ,
  • Stephen R. Spellman

      Affiliations

    • National Marrow Donor Program, Minneapolis, Minneapolis
    • ,
  • Michael D. Haagenson

      Affiliations

    • Center for International Blood and Marrow Transplant Research, Minneapolis, Minnesota
    • ,
  • Tao Wang

      Affiliations

    • Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin
    • ,
  • Marcelo Fernandez-Vina

      Affiliations

    • M.D. Anderson Cancer Center, Houston, Texas
    • ,
  • Steven G.E. Marsh

      Affiliations

    • Anthony Nolan Research Institute & UCL Cancer Institute, UCL, London, United Kingdom
    • ,
  • Mary Horowitz

      Affiliations

    • Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin
    • ,
  • Carolyn Katovich Hurley

      Affiliations

    • Georgetown University, Washington, DC

Received 27 January 2009 ,Accepted 24 April 2009.

References 

  1. Lee SJ, Klein J, Haagenson M, et al. High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation. Blood. 2007;110:4576–4583
  2. Hurley CK, Baxter-Lowe LA, Logan B, et al. National Marrow Donor Program HLA-matching guidelines for unrelated marrow transplants. Biol Blood Marrow Transplant. 2003;9:610–615
  3. Bray RA, Hurley CA, et al. National marrow donor program HLA matching guidelines for unrelated adult donor hematopoietic cell transplants. Biol Blood Marrow Transplant. 2008;14(Suppl):45–53
  4. Flomenberg N, Baxter-Lowe LA, Confer D, et al. Impact of HLA class I and class II high-resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C mismatching is associated with a strong adverse effect on transplantation outcome. Blood. 2004;104:1923–1930
  5. Morishima Y, Sasazuki T, Inoko H, et al. The clinical significance of human leukocyte antigen (HLA) allele compatibility in patients receiving a marrow transplant from serologically HLA-A, HLA-B, and HLA-DR matched unrelated donors. Blood. 2002;99:4200–4206
  6. Loiseau P, Busson M, Balere ML, et al. HLA Association with hematopoietic stem cell transplantation outcome: the number of mismatches at HLA-A, -B, -C, -DRB1, or -DQB1 is strongly associated with overall survival. Biol Blood Marrow Transplant. 2007;13:965–974
  7. Petersdorf EW, Anasetti C, Martin PJ, et al. Limits of HLA mismatching in unrelated hematopoietic cell transplantation. Blood. 2004;104:2976–2980
  8. Petersdorf EW, Hansen JA, Martin PJ, et al. Major-histocompatibility-complex class I alleles and antigens in hematopoietic-cell transplantation. N Engl J Med. 2001;345:1794–1800
  9. Petersdorf EW, Longton GM, Anasetti C, et al. Definition of HLA-DQ as a transplantation antigen. Proc Natl Acad Sci USA. 1996;93:15358–15363
  10. Shaw BE, Gooley TA, Malkki M, et al. The importance of HLA-DPB1 in unrelated donor hematopoietic cell transplantation. Blood. 2007;110:4560–4566
  11. Gallardo D, Salut B, Antonio T, et al. Hla-DPB1 mismatch in HLA-A-B-DRB1 identical sibling donor stem cell transplantation and acute graft-versus-host disease. Transplantation. 2004;77:1107–1110
  12. Kawase T, Morishima Y, Matsuo K, et al. High-risk HLA allele mismatch combinations responsible for severe acute graft-versus-host disease and implication for its molecular mechanism. Blood. 2007;110:2235–2241
  13. Halloran PF, Reeve J, Kaplan G. Lies, damn lies, and statistics: the perils of the P value. Am J Transplant. 2006;6:10–11
  14. Morishima Y, Kawase T, Malkki M, et al. Effect of HLA-A2 allele disparity on clinical outcome in hematopoietic cell transplantation from unrelated donors. Tissue Antigens/. 2007;69(Suppl 1):31–35
  15. Archbold JK, Ely LK, Kjer-Nielsen L, et al. T cell allorecognition and MHC restriction—a case of Jekyll and Hyde?. Mol Immunol. 2008;45:583–598
  16. Felix NJ, Allen PM. Specificity of T-cell alloreactivity. Nat Rev Immunol. 2007;7:942–953
  17. Elsner HA, DeLuca D, Strub J, et al. HistoCheck: rating of HLA class I and II mismatches by an internet-based software tool. Bone Marrow Transplant. 2004;33:165–169
  18. Heemskerk MB, Doxiadis N, Roelen DL, et al. The HistoCheck algorithm does not predict T-cell alloreactivity in vitro. Bone Marrow Transplant. 2005;36:927–928
  19. Shaw BE, Barber LD, Madrigal JA, et al. Scoring for HLA matching? A clinical test of HistoCheck. Bone Marrow Transplant. 2004;34:367–368author reply 369
  20. Duquesnoy R, Spellman S, Haagenson M, et al. HLAMatchmaker-defined triplet matching is not associated with better survival rates of patients with class I HLA allele mismatched hematopoietic cell transplants from unrelated donors. Biol Blood Marrow Transplant. 2008;14:1064–1071
  21. Hurley CK, Fernandez-Vina M, Hildebrand WH, et al. A high degree of HLA disparity arises from limited allelic diversity: analysis of 1775 unrelated bone marrow transplant donor-recipient pairs. Hum Immunol. 2007;68:30–40
  22. Robinson J, Waller MJ, Parham P, et al. IMGT/HLA Database—a sequence database for the human major histocompatibility complex. Nucleic Acids Res. 2001;29:210–213
  23. Bjorkman PJ, Saper MA, Samraoui B, et al. Structure of the human class I histocompatibility antigen, HLA-A2. Nature. 1987;329:506–512
  24. Saper MA, Bjorkman PJ, Wiley DC. Refined structure of the human histocompatibility antigen HLA-A2 at 2.6 A resolution. J Mol Biol. 1991;219:277–319
  25. Garrett TP, Saper MA, Bjorkman PJ, et al. Specificity pockets for the side chains of peptide antigens in HLA-Aw68. Nature. 1989;342:692–696
  26. Chelvanayagam G. A roadmap for HLA-A, HLA-B, and HLA-C peptide binding specificities. Immunogenetics. 1996;45:15–26
  27. Glucksberg H, et al. Clinical manifestations of graft-versus-host disease in human recipients of marrow from HL-A-matched sibling donors. Transplantation. 1974;18:295–304
  28. Shulman HM, Sullivan KM, Weiden PL, et al. Chronic graft-versus-host syndrome in man. A long-term clinicopathologic study of 20 Seattle patients. Am J Med. 1980;69:204–217
  29. DiBrino M, Parker KC, Margulies DH, et al. Identification of the peptide binding motif for HLA-B44, one of the most common HLA-B alleles in the Caucasian population. Biochemistry. 1995;34:10130–10138
  30. Burrows SR, Silins SL, Cross SM, et al. Human leukocyte antigen phenotype imposes complex constraints on the antigen-specific cytotoxic T lymphocyte repertoire. Eur J Immunol. 1997;27:178–182
  31. Keever CA, Leong N, Cunningham I, et al. HLA-B44-directed cytotoxic T cells associated with acute graft-versus-host disease following unrelated bone marrow transplantation. Bone Marrow Transplant. 1994;14:137–145
  32. Fleischhauer K, Kernan NA, O'Reilly OJ, et al. Bone marrow-allograft rejection by T lymphocytes recognizing a single amino acid difference in HLA-B44. N Engl J Med. 1990;323:1818–1822
  33. Imanishi T, et al. HLA 1991 Proceedings of the Eleventh Histocompatibility Workshop and Conference. In Eleventh Histocompatibility Workshop and Conference, 1991. Yokahama Japan: Oxford University Press.
  34. Heemskerk MB, Roelen DL, Dankers MKA, et al. Allogeneic MHC class I molecules with numerous sequence differences do not elicit a CTL response. Hum Immunol. 2005;66:969–976
  35. Rudolph MG, Stanfield RL, Wilson IA. How TCRs bind MHCs, peptides, and coreceptors. Annu Rev Immunol. 2006;24:419–466

 Financial disclosure: See Acknowledgments on page 980.

PII: S1083-8791(09)00216-X

doi: 10.1016/j.bbmt.2009.04.015

Biology of Blood and Marrow Transplantation
Volume 15, Issue 8 , Pages 971-981 , August 2009

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