Biology of Blood and Marrow Transplantation
Volume 15, Issue 9 , Pages 1014-1025 , September 2009

An Approach to Predicting Hematopoietic Stem Cell Transplantation Outcome Using HLA-Mismatch Information Mapped on Protein Structure Data

  • Małgorzata Dudkiewicz

      Affiliations

    • Department of Experimental Design and Bioinformatics, Warsaw University of Life Sciences Warsaw, Poland
    • Corresponding Author InformationCorrespondence and reprint requests: Małgorzata Dudkiewicz, Warsaw University of Life Sciences, Department of Experimental Design and Bioinformatics, 159 Nowoursynowska, 02-776 Warsaw, Poland.
    • ,
  • Piotr Malanowski

      Affiliations

    • Central Bone Marrow Donor and Cord Blood Registry, POLTRANSPLANT, Warsaw, Poland
    • ,
  • Jarosław Czerwin´ski

      Affiliations

    • Central Bone Marrow Donor and Cord Blood Registry, POLTRANSPLANT, Warsaw, Poland
    • ,
  • Krzysztof Pawłowski

      Affiliations

    • Department of Experimental Design and Bioinformatics, Warsaw University of Life Sciences Warsaw, Poland
    • Nencki Institute of Experimental Biology, Warsaw, Poland

Received 24 February 2009 ,Accepted 11 May 2009.

References 

  1. Krogsgaard M, Prado N, Adams E, et al. Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation. Mol Cell. 2003;12:1367–1378
  2. Van der Merwe A, Davis SJ. Molecular interactions mediating T cell antigen recognition. Annu Rev Immunol. 2003;21:659–684
  3. Davis MM, Boniface JJ, Reich Z, et al. Ligand recognition by αβ T cell receptors. Annu Rev Immunol. 1998;16:523–544
  4. Germain RN, Stefanova I. The dynamics of T cell receptor signalling: complex orchestration and the key roles of tempo and cooperation. Annu Rev Immunol. 1999;17:467–522
  5. Miller P, Pazy Y, Conti B, et al. Single MHC mutation eliminates enthalpy associated with T cell receptor binding. J Mol Biol. 2007;373:315–327
  6. Garcia KC, Radu CG, Ho J, et al. Kinetics and thermodynamics of T cell receptor– autoantigen interactions in murine experimental autoimmune encephalomyelitis. Proc Natl Acad Sci USA. 2001;98:6818–6823
  7. Willcox BE, Gao GF, Wyer JR, et al. TCR binding to peptide-MHC stabilizes a flexible recognition interface. Immunity. 1999;10:357–365
  8. Rudolph MG, Wilson IA. The specifity of TCR–pMHC interaction. Curr Opin Immunol. 2002;14:52–65
  9. Rudolph MG, Stanfield RL, Wilson IA. How TCRs bind MHCs, peptides, and coreceptors. Ann Rev Immunol. 2006;24:419–466
  10. Stewart-Jones GB, McMichael AJ, Bell JI, et al. A structural basis for immunodominant human T cell receptor recognition. Nat Immunol. 2003;4:657–663
  11. Tynan FE, Reid HH, Kjer-Nielsen L, et al. A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule. Nat Immunol. 2007;8:268–276
  12. Shlomchik WD, Couzens MS, Tang CB, et al. Prevention of graft-versus-host disease by inactivation of host antigen-presenting cells. Science. 1999;285:412–415
  13. Petersdorf EW, Hansen J. New advances in hematopoietic cell transplantation. Curr Opin Hematol. 2008;15:549–554
  14. Petersdorf EW, Anasetti C, Martin P, et al. Genomics of unrelated-donor hematopoietic cell transplantation. Curr Opin Hematol. 2001;13:582–589
  15. Kircher B, Hack CE, Dickinson AM, et al. Towards functional transplant donor matching by measurement of granzyme A and granzyme B production levels. J Immunol Methods. 2004;293:51–59
  16. Flomenberg N, Baxter-Lowe LA, Confer DL, et al. Impact of HLA class I and class II high-resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C mismatching is associated with a strong adverse effect on transplantation outcome. Blood. 2004;104:19230–1930
  17. Lee ET. Statistical Methods for Survival Data Analysis. Belmont, CA: Lifetime Learning; 1980;
  18. Hurley CK, Lowe AB, Logan B, et al. National Marrow Donor Program HLA-matching guidelines for unrelated marrow transplants. Biol Blood Marrow Transplant. 2003;9:610–615
  19. Lee SJ, Klein J, Haagenson M, et al. High-resolution donor–recipient matching contributes to the success of unrelated donor marrow transplantation. Blood. 2007;110:4576–4583
  20. Ferrara G, Bacigalupo A, Lamparelli T, et al. Bone marrow transplanatation from unrelated donors: the impact of mismatches with substitutions at position 116 of the human leukocyte antigen class I heavy chain. Blood. 2001;98:3150–3155
  21. Petersdorf EW, Malkki M, Gooley TA, et al. MHC haplotype matching for unrelated hematopoietic cell transplanatation. PLoS Med. 2007;4:59–67
  22. Kjer-Nielsen L, Clements CS, Purcell AW, et al. A structural basis for the selection of dominant αβ T cell receptors in antivirial immunity. Immunity. 2003;18:53–64
  23. Peto R, Peto J. Asymptotically efficient rank-invariant procedures. J Royal Stat Soc A. 1972;135:185–207
  24. Barett AJ, Rezvani K, Solomon S, et al. New developments in allotransplant immunology. Am Soc Hematol. 2003;350–371

 Financial disclosure: See Acknowledgments on page 1024.

PII: S1083-8791(09)00248-1

doi: 10.1016/j.bbmt.2009.05.011

Biology of Blood and Marrow Transplantation
Volume 15, Issue 9 , Pages 1014-1025 , September 2009

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