Biology of Blood and Marrow Transplantation
Volume 16, Issue 1 , Pages 132-133 , January 2010

CCR5 Expression on Cells from HLA-Matched Unrelated Marrow Donors and Graft-versus-Host Disease

  • Qing Ma

      Affiliations

    • Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington
    • ,
  • Ted A. Gooley

      Affiliations

    • Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington
    • ,
  • Rainer F. Storb

      Affiliations

    • Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington
    • School of Medicine and Public Health, University of Washington, Seattle, Washington

References 

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  2. Hancock WW. Chemokine receptor-dependent alloresponses. Immunol Rev. 2003;196:37–50
  3. Murai M, Yoneyama H, Harada A, et al. Related active participation of CCR5+CD8+ T lymphocytes in the pathogenesis of liver injury in graft-versus-host disease. J Clin Invest. 1999;104:49–57
  4. Serody JS, Burkett SE, Panoskaltsis-Mortari A, et al. T-lymphocyte production of macrophage inflammatory protein-1alpha is critical to the recruitment of CD8+ T cells to the liver, lung, and spleen during graft-versus-host disease. Blood. 2000;96:2973–2980
  5. Murai M, Yoneyama H, Ezaki T, et al. Peyer's patch is the essential site in initiating murine acute and lethal graft-versus-host reaction. Nat Immunol. 2003;4:154–160
  6. Smith MW, Dean M, Carrington M, et al. Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression. Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC), ALIVE Study. Science. 1997;277:959–965
  7. Smith MW, Dean M, Carrington M, Huttley GA, O'Brien SJ. CCR5-delta 32 gene deletion in HIV-1 infected patients. Lancet. 1997;350:741
  8. Fischereder M, Luckow B, Hocher B, et al. CC chemokine receptor 5 and renal-transplant survival. Lancet. 2001;357:1758–1761
  9. Hansen JA, Gooley TA, Martin PJ, et al. Bone marrow transplants from unrelated donors for patients with chronic myeloid leukemia. N Engl J Med. 1998;338:962–968
  10. Dhami H, Fritz CE, Gankin B, et al. The chemokine system and CCR5 antagonists: potential in HIV treatment and other novel therapies. J Clin Pharm Ther. 2009;34:147–160

PII: S1083-8791(09)00258-4

doi: 10.1016/j.bbmt.2009.05.017

Biology of Blood and Marrow Transplantation
Volume 16, Issue 1 , Pages 132-133 , January 2010

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