Osteochondroma after Hematopoietic Stem Cell Transplantation in Childhood. An Italian Study on Behalf of the AIEOP-HSCT Group

Faraci, Maura; Bagnasco, Francesca; Corti, Paola; Messina, Chiara; Fagioli, Franca; Podda, Marta; Prete, Arcangelo; Caselli, Desirè; Lanino, Edoardo; Dini, Giorgio; Rondelli, Roberto; Haupt, Riccardo; AIEOP-HSCT Group,

doi:10.1016/j.bbmt.2009.06.003

« Previous Next »Biology of Blood and Marrow Transplantation
Volume 15, Issue 10 , Pages 1271-1276, October 2009

Osteochondroma after Hematopoietic Stem Cell Transplantation in Childhood. An Italian Study on Behalf of the AIEOP-HSCT Group

Maura Faraci
- Department of Hematology-Oncology, Bone Marrow Transplant Unit, G. Gaslini Children's Hospital, Genova, Italy
- Correspondence and reprint requests: Maura Faraci, MD, Department of Oncology/Oncology, Stem Cell Transplantation Section, G. Gaslini Children's Hospital, Largo G. Gaslini, 5; 16147 Genova, Italy.
Francesca Bagnasco
- Epidemiology and Biostatistics Section, Scientific Directorate, G. Gaslini Children's Hospital, Genova, Italy
Paola Corti
- Bone Marrow Unit, Clinic of Pediatrics, University of Milano Bicocca, San Gerardo Hospital, Monza, Italy
Chiara Messina
- Clinic of Pediatric Hematology Oncology, Department of Pediatrics, University of Padova, Padova, Italy
Franca Fagioli
- Clinic of Pediatric Hematology Oncology, Department of Pediatrics, Regina Margherita Pediatric Hospital, Torino, Italy
Marta Podda
- Pediatric Oncology Unit, Foundation IRCSS, Institute National of Tumors, Milano, Italy
Arcangelo Prete
- Department of Pediatrics, University of Bologna, Sant'Orsola Hospital, Bologna, Italy
Desirè Caselli
- DAI, Oncology-Oncology and Home Care, AUO Mayer, Firenze, Italy
Edoardo Lanino
- Department of Hematology-Oncology, Bone Marrow Transplant Unit, G. Gaslini Children's Hospital, Genova, Italy
Giorgio Dini
- Department of Hematology-Oncology, Bone Marrow Transplant Unit, G. Gaslini Children's Hospital, Genova, Italy
Roberto Rondelli
- Department of Pediatrics, University of Bologna, Sant'Orsola Hospital, Bologna, Italy
Riccardo Haupt
- Epidemiology and Biostatistics Section, Scientific Directorate, G. Gaslini Children's Hospital, Genova, Italy
AIEOP-HSCT Group

Received 6 April 2009; accepted 4 June 2009. published online 10 August 2009.

A retrospective study was conducted among Italian children treated with hematopoietic stem cell transplant (HSCT) to evaluate the incidence and risk factors in the development of osteochondroma (OC). OC occurred in 27 patients who received autologous or allogeneic HSCT. The estimated 5-, 10-, and 15-year cumulative risk of developing OC was 0.5%, 3.2%, and 6.1%, respectively. Analysis of cumulative risk stratified by the various risk factors revealed that male sex (P=.026), autologous HSCT (P=.001), age at HSCT (≤3 years) (P < .0001), and total body irradiation (TBI) (P <.0001) significantly affected the risk of OC. Multivariate analysis, restricted only to tumor types with at least 1 case of OC, showed that earlier age at HSCT (P =.0004) and TBI (P < .0001) were the only factors that were significantly associated with OC.