Osteochondroma after Hematopoietic Stem Cell Transplantation in Childhood. An Italian Study on Behalf of the AIEOP-HSCT Group
Received 6 April 2009; accepted 4 June 2009. published online 10 August 2009.
A retrospective study was conducted among Italian children treated with hematopoietic stem cell transplant (HSCT) to evaluate the incidence and risk factors in the development of osteochondroma (OC). OC occurred in 27 patients who received autologous or allogeneic HSCT. The estimated 5-, 10-, and 15-year cumulative risk of developing OC was 0.5%, 3.2%, and 6.1%, respectively. Analysis of cumulative risk stratified by the various risk factors revealed that male sex (P=.026), autologous HSCT (P=.001), age at HSCT (≤3 years) (P < .0001), and total body irradiation (TBI) (P <.0001) significantly affected the risk of OC. Multivariate analysis, restricted only to tumor types with at least 1 case of OC, showed that earlier age at HSCT (P =.0004) and TBI (P < .0001) were the only factors that were significantly associated with OC.
1Department of Hematology-Oncology, Bone Marrow Transplant Unit, G. Gaslini Children's Hospital, Genova, Italy
2Epidemiology and Biostatistics Section, Scientific Directorate, G. Gaslini Children's Hospital, Genova, Italy
3Bone Marrow Unit, Clinic of Pediatrics, University of Milano Bicocca, San Gerardo Hospital, Monza, Italy
4Clinic of Pediatric Hematology Oncology, Department of Pediatrics, University of Padova, Padova, Italy
5Clinic of Pediatric Hematology Oncology, Department of Pediatrics, Regina Margherita Pediatric Hospital, Torino, Italy
6Pediatric Oncology Unit, Foundation IRCSS, Institute National of Tumors, Milano, Italy
7Department of Pediatrics, University of Bologna, Sant'Orsola Hospital, Bologna, Italy
8DAI, Oncology-Oncology and Home Care, AUO Mayer, Firenze, Italy
Correspondence and reprint requests: Maura Faraci, MD, Department of Oncology/Oncology, Stem Cell Transplantation Section, G. Gaslini Children's Hospital, Largo G. Gaslini, 5; 16147 Genova, Italy.
Financial disclosure: See Acknowledgments on page 1276.
ABSTRACT