Biology of Blood and Marrow Transplantation
Volume 15, Issue 11 , Pages 1386-1393 , November 2009

Failure to Achieve a Threshold Dose of CD34+CD110+ Progenitor Cells in the Graft Predicts Delayed Platelet Engraftment after Autologous Stem Cell Transplantation for Multiple Myeloma

  • Craig T. Wallington-Beddoe

      Affiliations

    • Hematology Department, Westmead Hospital, Sydney, Australia
    • University of Sydney, Sydney, Australia
    • Corresponding Author InformationCorrespondence and reprint requests: Craig T. Wallington-Beddoe, BSc (Hons), MB BS (Hons), Hematology Department, Westmead Hospital, Hawkesbury Road, Westmead, Sydney NSW 2145, Australia.
    • ,
  • David J. Gottlieb

      Affiliations

    • Hematology Department, Westmead Hospital, Sydney, Australia
    • Sydney Cellular Therapies Laboratory, Westmead Hospital, Sydney, Australia
    • University of Sydney, Sydney, Australia
    • ,
  • Fran Garvin

      Affiliations

    • Sydney Cellular Therapies Laboratory, Westmead Hospital, Sydney, Australia
    • ,
  • Vicki Antonenas

      Affiliations

    • Sydney Cellular Therapies Laboratory, Westmead Hospital, Sydney, Australia
    • ,
  • Mary M. Sartor

      Affiliations

    • Flow Cytometry Unit, Westmead Hospital, Sydney, Australia

Received 18 March 2009 ,Accepted 26 June 2009.

  • Image Result

    Correlation between absolute number of CD34+ and absolute number of CD34+CD110+ cells/kg infused at the time of transplant. R2 = .46, n = 72.

    Correlation between absolute number of CD34+ and absolute number of CD34+CD110+ cells/kg infused at the time of transplant. R2 = .46, n = 72.

  • Image Result

    Number of (A) CD34+ cells × 106/kg and (B) CD34+CD110+ cells × 104/kg harvested on each day of collection for patients having 2 leukaphereses (n = 15) or 3 leukaphereses (n = 4) in preparation for aut

    Number of (A) CD34+ cells × 106/kg and (B) CD34+CD110+ cells × 104/kg harvested on each day of collection for patients having 2 leukaphereses (n = 15) or 3 leukaphereses (n = 4) in preparation for autologous stem cell transplantation.

  • Image Result
    (A) Number of days to platelet engraftment plotted against absolute number of CD34+CD110+ cells/kg infused at the time of transplant. Vertical line indicates a threshold of 3.0 × 104 CD34+CD110+ cells

    (A) Number of days to platelet engraftment plotted against absolute number of CD34+CD110+ cells/kg infused at the time of transplant. Vertical line indicates a threshold of 3.0 × 104 CD34+CD110+ cells/kg and the horizontal line represents 21 days post transplant. (B) Number of days to platelet engraftment plotted against absolute number of CD34+cells/kg infused at the time of transplant. Vertical line indicates a threshold of 2.0 × 106 CD34+ cells/kg and the horizontal line represents 21 days post transplant.

  • Image Result
    Dose effect of increasing numbers of CD34+CD110+ cells/kg on platelet engraftment (bars represent median values).

    Dose effect of increasing numbers of CD34+CD110+ cells/kg on platelet engraftment (bars represent median values).

 Financial disclosure: See Acknowledgments on page 1392.

PII: S1083-8791(09)00302-4

doi: 10.1016/j.bbmt.2009.06.018

Biology of Blood and Marrow Transplantation
Volume 15, Issue 11 , Pages 1386-1393 , November 2009

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