Biology of Blood and Marrow Transplantation
Volume 15, Issue 11 , Pages 1447-1454 , November 2009

Busulfan and Cyclophosphamide (Bu/Cy) as a Preparative Regimen for Autologous Stem Cell Transplantation in Patients with Non-Hodgkin Lymphoma: A Single-Institution Experience

  • Matthew Ulrickson

      Affiliations

    • Department of Hematology/Oncology, Massachusetts General Hospital, Boston, Massachusetts
    • ,
  • Julie Aldridge

      Affiliations

    • Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts
    • ,
  • Haesook T. Kim

      Affiliations

    • Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts
    • ,
  • Ephraim P. Hochberg

      Affiliations

    • Department of Hematology/Oncology, Massachusetts General Hospital, Boston, Massachusetts
    • ,
  • Peter Hammerman

      Affiliations

    • Department of Hematology/Oncology, Massachusetts General Hospital, Boston, Massachusetts
    • ,
  • Christine Dube

      Affiliations

    • Department of Hematology/Oncology, Massachusetts General Hospital, Boston, Massachusetts
    • ,
  • Eyal Attar

      Affiliations

    • Department of Hematology/Oncology, Massachusetts General Hospital, Boston, Massachusetts
    • ,
  • Karen K. Ballen

      Affiliations

    • Department of Hematology/Oncology, Massachusetts General Hospital, Boston, Massachusetts
    • ,
  • Bimalangshu R. Dey

      Affiliations

    • Department of Hematology/Oncology, Massachusetts General Hospital, Boston, Massachusetts
    • ,
  • Steven L. McAfee

      Affiliations

    • Department of Hematology/Oncology, Massachusetts General Hospital, Boston, Massachusetts
    • ,
  • Thomas R. Spitzer

      Affiliations

    • Department of Hematology/Oncology, Massachusetts General Hospital, Boston, Massachusetts
    • ,
  • Yi-Bin Chen

      Affiliations

    • Department of Hematology/Oncology, Massachusetts General Hospital, Boston, Massachusetts
    • Corresponding Author InformationCorrespondence and reprint requests: Yi-Bin Chen, MD, Division of Bone Marrow Transplantation, Department of Hematology/Oncology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114.

Received 25 March 2009 ,Accepted 14 July 2009.

References 

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  3. Rohatiner AZ, Nadler L, Davies AJ, et al. Myeloablative therapy with autologous bone marrow transplantation for follicular lymphoma at the time of second or subsequent remission: long-term follow-up. J Clin Oncol. 2007;25:2554–2559
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  19. Ballester OF, Agaliotis DP, Hiemenz JW, et al. Phase I-II study of high-dose busulfan and cyclophosphamide followed by autologous peripheral blood stem cell transplantation for hematological malignancies: toxicities and hematopoietic recovery. Bone Marrow Transplant. 1996;18:9–14
  20. Copelan EA, Penza SL, Pohlman B, et al. Autotransplantation following busulfan, etoposide and cyclophosphamide in patients with non-Hodgkin's lymphoma. Bone Marrow Transplant. 2000;25:1243–1248
  21. de Magalhaes-Silverman M, Lister J, Rybka W, et al. Busulfan and cyclophosphamide (BU/CY2) as preparative regimen for patients with lymphoma. Bone Marrow Transplant. 1997;19:777–781
  22. Schiffman KS, Bensinger WI, Appelbaum FR, et al. Phase II study of high-dose busulfan, melphalan and thiotepa with autologous peripheral blood stem cell support in patients with malignant disease. Bone Marrow Transplant. 1996;17:943–950
  23. Weaver CH, Schwartzberg L, Rhinehart S, et al. High-dose chemotherapy with BUCY or BEAC and unpurged peripheral blood stem cell infusion in patients with low-grade non-Hodgkin's lymphoma. Bone Marrow Transplant. 1998;21:383–389
  24. Zaucha R, Gooley T, Holmberg L, et al. High-dose chemotherapy with BEAM or busulphan/melphalan and thiotepa followed by hematopoietic cell transplantation in malignant lymphoma. Leuk Lymphoma. 2008;49:1899–1906
  25. Diez-Martin JL, Balsalobre P, Re A, et al. Comparable survival between HIV+ and HIV- non-Hodgkin and Hodgkin lymphoma patients undergoing autologous peripheral blood stem cell transplantation. Blood. 2009;113:6011–6014
  26. Fernandez H. The use of intravenous busulfan and cyclophosphamide as a conditioning regimen for non-Hodgkin's lymphoma. Presented at the ASBMT/CIBMTR Tandem Meetings. Honolulu: Hawaii; 2006;

 Financial disclosure: See Acknowledgments on page 1453.

PII: S1083-8791(09)00343-7

doi: 10.1016/j.bbmt.2009.07.014

Biology of Blood and Marrow Transplantation
Volume 15, Issue 11 , Pages 1447-1454 , November 2009

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