Biology of Blood and Marrow Transplantation
Volume 15, Issue 12 , Pages 1502-1512 , December 2009

Proteasome Inhibition and Allogeneic Hematopoietic Stem Cell Transplantation: A Review

  • John Koreth

      Affiliations

    • Division of Hematologic Malignancies, Dana-Farber Cancer Institute, Boston, Massachustts
    • ,
  • Edwin P. Alyea

      Affiliations

    • Division of Hematologic Malignancies, Dana-Farber Cancer Institute, Boston, Massachustts
    • ,
  • William J. Murphy

      Affiliations

    • Department of Dermatology, UC Davis School of Medicine, Sacramento, California
    • Corresponding Author InformationCorrespondence and reprint requests: William J. Murphy, MD, PhD, Department of Dermatology, University of California, Davis School of Medicine, Research III, Room 3300, 4645 2nd Avenue, Sacramento, CA 95818.
    • ,
  • Lisbeth A. Welniak

      Affiliations

    • Department of Dermatology, UC Davis School of Medicine, Sacramento, California

Received 15 June 2009 ,Accepted 16 July 2009.

  • Image Result

    Potential mode of action in bortezomib mediated antitumor responses. Bortezomib may have a negative impact on the growth and spread of cancer cells through multiple mechanisms including direct inducti

    Potential mode of action in bortezomib mediated antitumor responses. Bortezomib may have a negative impact on the growth and spread of cancer cells through multiple mechanisms including direct induction of apoptosis, sensitization to killing by CD8+ cytotoxic T cells and NK cells, and through reduction of inflammation resulting in decreased metastasis.

 Financial disclosure: See Acknowledgments on page 1509.

PII: S1083-8791(09)00344-9

doi: 10.1016/j.bbmt.2009.07.016

Biology of Blood and Marrow Transplantation
Volume 15, Issue 12 , Pages 1502-1512 , December 2009

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