Biology of Blood and Marrow Transplantation
Volume 15, Issue 12 , Pages 1531-1537 , December 2009

Infectious Complications after Unrelated Umbilical Cord Blood Transplantation in Adult Patients with Hematologic Malignancies

  • Xavier Cahu

      Affiliations

    • CHU de Nantes, Service d'Hématologie Clinique, Nantes, France
    • ,
  • Fanny Rialland

      Affiliations

    • CHU de Nantes, Service d'Hématologie Clinique, Nantes, France
    • ,
  • Cyrille Touzeau

      Affiliations

    • CHU de Nantes, Service d'Hématologie Clinique, Nantes, France
    • ,
  • Patrice Chevallier

      Affiliations

    • CHU de Nantes, Service d'Hématologie Clinique, Nantes, France
    • ,
  • Thierry Guillaume

      Affiliations

    • CHU de Nantes, Service d'Hématologie Clinique, Nantes, France
    • ,
  • Jacques Delaunay

      Affiliations

    • CHU de Nantes, Service d'Hématologie Clinique, Nantes, France
    • ,
  • Sameh Ayari

      Affiliations

    • CHU de Nantes, Service d'Hématologie Clinique, Nantes, France
    • ,
  • Viviane Dubruille

      Affiliations

    • CHU de Nantes, Service d'Hématologie Clinique, Nantes, France
    • ,
  • Steven Le Gouill

      Affiliations

    • CHU de Nantes, Service d'Hématologie Clinique, Nantes, France
    • Université de Nantes and INSERM CRCNA U892, Nantes, France
    • ,
  • Beatrice Mahe

      Affiliations

    • CHU de Nantes, Service d'Hématologie Clinique, Nantes, France
    • ,
  • Thomas Gastinne

      Affiliations

    • CHU de Nantes, Service d'Hématologie Clinique, Nantes, France
    • ,
  • Nicolas Blin

      Affiliations

    • CHU de Nantes, Service d'Hématologie Clinique, Nantes, France
    • ,
  • Beatrice Saulquin

      Affiliations

    • CHU de Nantes, Service d'Hématologie Clinique, Nantes, France
    • ,
  • Jean-Luc Harousseau

      Affiliations

    • CHU de Nantes, Service d'Hématologie Clinique, Nantes, France
    • Université de Nantes and INSERM CRCNA U892, Nantes, France
    • Current address of Jean-Luc Harousseau: Centre Régional de Lutte contre le Cancer (CRLCC) René Gauducheau, Nantes, France.
    • ,
  • Philippe Moreau

      Affiliations

    • CHU de Nantes, Service d'Hématologie Clinique, Nantes, France
    • Université de Nantes and INSERM CRCNA U892, Nantes, France
    • ,
  • Mohamad Mohty

      Affiliations

    • CHU de Nantes, Service d'Hématologie Clinique, Nantes, France
    • Université de Nantes and INSERM CRCNA U892, Nantes, France
    • Centre d'Investigation Clinique en Cancérologie (CI2C), CHU de Nantes, Nantes, France
    • Corresponding Author InformationCorrespondence and reprint requests: Prof. Mohamad Mohty, Hématologie Clinique, CHU de Nantes, Place A. Ricordeau, F-44093 Nantes Cedex, France.

Received 26 May 2009 ,Accepted 24 July 2009.

References 

  1. Tse W, Laughlin MJ. Umbilical cord blood transplantation: a new alternative option. Hematol Am Soc Hematol Educ Program. 2005;377–383
  2. Rocha V, Labopin M, Sanz G, et al. Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia. N Engl J Med. 2004;351:2276–2285
  3. Laughlin MJ, Eapen M, Rubinstein P, et al. Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia. N Engl J Med. 2004;351:2265–2275
  4. Rodrigues CA, Sanz G, Brunstein CG, et al. Analysis of risk factors for outcomes after unrelated cord blood transplantation in adults with lymphoid malignancies: a study by the Eurocord-Netcord and lymphoma working party of the European group for blood and marrow transplantation. J Clin Oncol. 2009;27:256–263
  5. Atsuta Y, Suzuki R, Nagamura-Inoue T, et al. Disease-specific analyses of unrelated cord blood transplantation compared with unrelated bone marrow transplantation in adult patients with acute leukemia. Blood. 2009;113:1631–1638
  6. Cornetta K, Laughlin M, Carter S, et al. Umbilical cord blood transplantation in adults: results of the prospective Cord Blood Transplantation (COBLT). Biol Blood Marrow Transplant. 2005;11:149–160
  7. Saavedra S, Sanz GF, Jarque I, et al. Early infections in adult patients undergoing unrelated donor cord blood transplantation. Bone Marrow Transplant. 2002;30:937–943
  8. Long GD, Laughlin M, Madan B, et al. Unrelated umbilical cord blood transplantation in adult patients. Biol Blood Marrow Transplant. 2003;9:772–780
  9. Safdar A, Rodriguez GH, De Lima MJ, et al. Infections in 100 cord blood transplantations: spectrum of early and late posttransplant infections in adult and pediatric patients 1996-2005. Medicine (Baltimore). 2007;86:324–333
  10. Parody R, Martino R, Rovira M, et al. Severe infections after unrelated donor allogeneic hematopoietic stem cell transplantation in adults: comparison of cord blood transplantation with peripheral blood and bone marrow transplantation. Biol Blood Marrow Transplant. 2006;12:734–748
  11. Brunstein CG, Barker JN, Weisdorf DJ, et al. Umbilical cord blood transplantation after nonmyeloablative conditioning: impact on transplantation outcomes in 110 adults with hematologic disease. Blood. 2007;110:3064–3070
  12. Alizadeh M, Bernard M, Danic B, et al. Quantitative assessment of hematopoietic chimerism after bone marrow transplantation by real-time quantitative polymerase chain reaction. Blood. 2002;99:4618–4625
  13. Ascioglu S, Rex JH, de Pauw B, et al. Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus. Clin Infect Dis. 2002;34:7–14
  14. Ljungman P, de la Camara R, Cordonnier C, et al. Management of CMV, HHV-6, HHV-7 and Kaposi-sarcoma herpesvirus (HHV-8) infections in patients with hematological malignancies and after SCT. Bone Marrow Transplant. 2008;42:227–240
  15. Klein JP, Rizzo JD, Zhang MJ, Keiding N. Statistical methods for the analysis and presentation of the results of bone marrow transplants. Part I: unadjusted analysis. Bone Marrow Transplant. 2001;28:909–915
  16. Wagner JE, Barker JN, DeFor TE, et al. Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival. Blood. 2002;100:1611–1618
  17. Laughlin MJ, Barker J, Bambach B, et al. Hematopoietic engraftment and survival in adult recipients of umbilical-cord blood from unrelated donors. N Engl J Med. 2001;344:1815–1822
  18. Barker JN, Weisdorf DJ, DeFor TE, et al. Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy. Blood. 2005;105:1343–1347
  19. Guidelines for preventing opportunistic infections among hematopoietic stem cell transplant recipients. Biol Blood Marrow Transplant. 2000;6:659-713; 715; 717-627; quiz 729–633
  20. Hamza NS, Lisgaris M, Yadavalli G, et al. Kinetics of myeloid and lymphocyte recovery and infectious complications after unrelated umbilical cord blood versus HLA-matched unrelated donor allogeneic transplantation in adults. Br J Haematol. 2004;124:488–498
  21. Narimatsu H, Matsumura T, Kami M, et al. Bloodstream infection after umbilical cord blood transplantation using reduced-intensity stem cell transplantation for adult patients. Biol Blood Marrow Transplant. 2005;11:429–436
  22. Yazaki M, Atsuta Y, Kato K, et al. Incidence and risk factors of early bacterial infections after unrelated cord blood transplantation. Biol Blood Marrow Transplant. 2009;15:439–446
  23. Miyakoshi S, Kusumi E, Matsumura T, et al. Invasive fungal infection following reduced-intensity cord blood transplantation for adult patients with hematologic diseases. Biol Blood Marrow Transplant. 2007;13:771–777
  24. Komanduri KV, St John LS, de Lima M, et al. Delayed immune reconstitution after cord blood transplantation is characterized by impaired thymopoiesis and late memory T-cell skewing. Blood. 2007;110:4543–4551
  25. Alpdogan O, Schmaltz C, Muriglan SJ, et al. Administration of interleukin-7 after allogeneic bone marrow transplantation improves immune reconstitution without aggravating graft-versus-host disease. Blood. 2001;98:2256–2265
  26. Alpdogan O, Eng JM, Muriglan SJ, et al. Interleukin-15 enhances immune reconstitution after allogeneic bone marrow transplantation. Blood. 2005;105:865–873

 Financial disclosure: See Acknowledgments on page 1536.

PII: S1083-8791(09)00362-0

doi: 10.1016/j.bbmt.2009.07.021

Biology of Blood and Marrow Transplantation
Volume 15, Issue 12 , Pages 1531-1537 , December 2009

Article Tools

* Image Usage & Resolution