Biology of Blood and Marrow Transplantation
Volume 15, Issue 12 , Pages 1571-1577 , December 2009

Polymorphism of Interleukin-23 Receptor Gene But Not of NOD2/CARD15 Is Associated with Graft-versus-Host Disease after Hematopoietic Stem Cell Transplantation in Children

  • Bernd Gruhn

      Affiliations

    • Department of Pediatrics, University of Jena, Jena, Germany
    • Corresponding Author InformationCorrespondence and reprint requests: Bernd Gruhn, MD, University Children's Hospital Jena. 07740 Jena, Germany.
    • ,
  • Juliane Intek

      Affiliations

    • Department of Pediatrics, University of Jena, Jena, Germany
    • ,
  • Nadine Pfaffendorf

      Affiliations

    • Department of Pediatrics, University of Jena, Jena, Germany
    • ,
  • Roland Zell

      Affiliations

    • Institute for Virology and Antiviral Therapy, University of Jena, Jena, Germany
    • ,
  • Selim Corbacioglu

      Affiliations

    • Department of Pediatrics, University of Ulm, Ulm, Germany
    • ,
  • Felix Zintl

      Affiliations

    • Department of Pediatrics, University of Jena, Jena, Germany
    • ,
  • James F. Beck

      Affiliations

    • Department of Pediatrics, University of Jena, Jena, Germany
    • ,
  • Klaus-Michael Debatin

      Affiliations

    • Department of Pediatrics, University of Ulm, Ulm, Germany
    • ,
  • Daniel Steinbach

      Affiliations

    • Department of Pediatrics, University of Ulm, Ulm, Germany
    • Corresponding Author InformationDaniel Steinbach, MD, University Children's Hospital Ulm, 89075 Ulm, Germany.

  • Image Result

    The IL23R-1142 G>A allele in the donor is associated with less severe and less frequent GVHD (Spearman correlation P=.024). Donor IL23R-1142 G>A positive, n=20; donor IL23R-1142 G>A negative, n=161.

    The IL23R-1142 G>A allele in the donor is associated with less severe and less frequent GVHD (Spearman correlation P=.024). Donor IL23R-1142 G>A positive, n=20; donor IL23R-1142 G>A negative, n=161.

  • Image Result

    Polymorphisms of IL23R and NOD2/CARD15 are not associated with OS after stem cell transplantation in children. (A) Patient IL23R-1142 G>A positive (n=17) versus patient IL23R-1142 G>A negative (n=200)

    Polymorphisms of IL23R and NOD2/CARD15 are not associated with OS after stem cell transplantation in children. (A) Patient IL23R-1142 G>A positive (n=17) versus patient IL23R-1142 G>A negative (n=200). (B) Donor IL23R-1142 G>A positive (n=20) versus donor IL23R-1142 G>A negative (n=161). (C) Patient positive for any of the 3 SNPs in NOD2/CARD15 (n=41) versus patient negative for all 3 SNPs (n=176). (D) Donor positive for any of the 3 SNPs in NOD2/CARD15 (n=33) versus patient negative for all 3 SNPs (n=148).

 Financial disclosure: See Acknowledgments on page 1576.

PII: S1083-8791(09)00367-X

doi: 10.1016/j.bbmt.2009.08.001

Biology of Blood and Marrow Transplantation
Volume 15, Issue 12 , Pages 1571-1577 , December 2009

Article Tools

* Image Usage & Resolution