Biology of Blood and Marrow Transplantation
Volume 15, Issue 12 , Pages 1571-1577 , December 2009

Polymorphism of Interleukin-23 Receptor Gene But Not of NOD2/CARD15 Is Associated with Graft-versus-Host Disease after Hematopoietic Stem Cell Transplantation in Children

  • Bernd Gruhn

      Affiliations

    • Department of Pediatrics, University of Jena, Jena, Germany
    • Corresponding Author InformationCorrespondence and reprint requests: Bernd Gruhn, MD, University Children's Hospital Jena. 07740 Jena, Germany.
    • ,
  • Juliane Intek

      Affiliations

    • Department of Pediatrics, University of Jena, Jena, Germany
    • ,
  • Nadine Pfaffendorf

      Affiliations

    • Department of Pediatrics, University of Jena, Jena, Germany
    • ,
  • Roland Zell

      Affiliations

    • Institute for Virology and Antiviral Therapy, University of Jena, Jena, Germany
    • ,
  • Selim Corbacioglu

      Affiliations

    • Department of Pediatrics, University of Ulm, Ulm, Germany
    • ,
  • Felix Zintl

      Affiliations

    • Department of Pediatrics, University of Jena, Jena, Germany
    • ,
  • James F. Beck

      Affiliations

    • Department of Pediatrics, University of Jena, Jena, Germany
    • ,
  • Klaus-Michael Debatin

      Affiliations

    • Department of Pediatrics, University of Ulm, Ulm, Germany
    • ,
  • Daniel Steinbach

      Affiliations

    • Department of Pediatrics, University of Ulm, Ulm, Germany
    • Corresponding Author InformationDaniel Steinbach, MD, University Children's Hospital Ulm, 89075 Ulm, Germany.

References 

  1. Dickinson AM, Middleton PG, Rocha V, Gluckman E, Holler E Eurobank members. Genetic polymorphisms predicting the outcome of bone marrow transplants. Br J Haematol. 2004;127:479–490
  2. Eckmann L, Karin M. NOD2 and Crohn's disease: loss or gain of function?. Immunity. 2005;22:661–667
  3. Parham C, Chirica M, Timans J, et al. A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R. J Immunol. 2002;168:5699–5708
  4. van den Eijnden S, Goriely S, De Wit D, Willems F, Goldman M. IL-23 up-regulates IL-10 and induces IL-17 synthesis by polyclonally activated naive T cells in human. Eur J Immunol. 2005;35:469–475
  5. Holler E, Rogler G, Herfarth H, et al. Both donor and recipient NOD2/CARD15 mutations associate with transplant-related mortality and GvHD following allogeneic stem cell transplantation. Blood. 2004;104:889–894
  6. Holler E, Rogler G, Brenmoehl J, et al. Prognostic significance of NOD2/CARD15 variants in HLA-identical sibling hematopoietic stem cell transplantation: effect on long-term outcome is confirmed in 2 independent cohorts and may be modulated by the type of gastrointestinal decontamination. Blood. 2006;107:4189–4193
  7. Holler E, Rogler G, Brenmoehl J, et al. The role of genetic variants of NOD2/CARD15, a receptor of the innate immune system, in GvHD and complications following related and unrelated donor haematopoietic stem cell transplantation. Int J Immunogenet. 2008;35:381–384
  8. Hildebrandt GC, Granell M, Urbano-Ispizua A, et al. Recipient NOD2/CARD15 variants: a novel independent risk factor for the development of bronchiolitis obliterans after allogeneic stem cell transplantation. Biol Blood Marrow Transplant. 2008;14:67–74
  9. Granell M, Urbano-Ispizua A, Aróstegui JI. Effect of NOD2/CARD15 variants in T-cell depleted allogeneic stem cell transplantation. Haematologica. 2006;91:1372–1376
  10. Elmaagacli AH, Koldehoff M, Hindahl H, et al. Mutations in innate immune system NOD2/CARD 15 and TLR-4 (Thr399Ile) genes influence the risk for severe acute graft-versus-host disease in patients who underwent an allogeneic transplantation. Transplantation. 2006;81:247–254
  11. Madrigal A, Shaw BE. Immunogenetic factors in donors and patients that affect the outcome of hematopoietic stem cell transplantation. Blood Cells Mol Dis. 2008;40:40–43
  12. Mayor NP, Shaw BE, Hughes DA, et al. Single nucleotide polymorphisms in the NOD2/CARD15 gene are associated with an increased risk of relapse and death for patients with acute leukemia after hematopoietic stem-cell transplantation with unrelated donors. J Clin Oncol. 2007;25:4262–4269
  13. Sairafi D, Uzunel M, Remberger M, Ringdén O, Mattsson J. No impact of NOD2/CARD15 on outcome after SCT. Bone Marrow Transplant. 2008;41:961–964
  14. Elmaagacli AH, Koldehoff M, Landt O, Beelen DW. Relation of an interleukin-23 receptor gene polymorphism to graft-versus-host disease after hematopoietic-cell transplantation. Bone Marrow Transplant. 2008;41:821–826
  15. Przepiorka D, Weisdorf D, Martin P, et al. 1994 Consensus conference on acute GVHD grading. Bone Marrow Transplant. 1995;15:825–828
  16. Sullivan KM, Agura E, Anasetti C, et al. Chronic graft-versus-host disease and other late complications of bone marrow transplantation. Semin Hematol. 1991;28:250–259

 Financial disclosure: See Acknowledgments on page 1576.

PII: S1083-8791(09)00367-X

doi: 10.1016/j.bbmt.2009.08.001

Biology of Blood and Marrow Transplantation
Volume 15, Issue 12 , Pages 1571-1577 , December 2009

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