Outcome of 125 Children with Chronic Myelogenous Leukemia Who Received Transplants from Unrelated Donors: The Japan Marrow Donor Program

OS and LFS in children with Ph+ CML. In Kaplan-Meier curves graph, solid line shows the probabilities of OS (5-year OS=59.3%; 95% CI=54.8%-63.8%) and the dotted line shows that of LFS (5-year LFS=55.5%; 95% CI=51.0%-60.0%).

A and B, Relationship among infused total nucleated cell dose, OS (A), and TRM (B) in children with Ph+ CML. In the entire cohort, OS was significantly higher for children who received a higher infused total nucleated cell dose than those who received a lower dose (≥ 314×10⁶/kg vs<314×10⁶/kg; P=.001). TRM was significantly higher for children who received a lower cell dose than for those who received a higher cell dose (≥ 314×10⁶/kg vs<314×10⁶/kg; P=.003). Solid lines show the probabilities of OS and TRM for children who received a higher infused total nucleated cell dose and the dotted lines show the probabilities for those who received a lower infused total nucleated cell dose. C and D, OS (C) and TRM (D) of Ph+ CML children in CP1 with or without an MCyR. OS was significantly higher for children who achieved MCyR at the time of BMT (n=29) than for those who did not (n=39) (OS; P < .001) (C). TRM was also significantly higher for children who did not achieve MCyR (P=.005) (D). The solid lines show the probabilities of OS and TRM for children with MCyR at the time of BMT, and the dotted lines show the probabilities for those without.