Biology of Blood and Marrow Transplantation
Volume 16, Issue 2 , Pages 239-252 , February 2010

Association of HMGB1 Polymorphisms with Outcome after Allogeneic Hematopoietic Cell Transplantation

  • Brian Kornblit

      Affiliations

    • Laboratory of Molecular Medicine, Department of Clinical Immunology University of Copenhagen, Denmark
    • The Allogeneic Hematopoietic Cell Transplantation Laboratory, Department of Hematology, Rigshospitalet, University of Copenhagen, Denmark
    • Corresponding Author InformationCorrespondence and reprint requests: Brian Kornblit, MD, The Allogeneic Hematopoietic Cell Transplantation Laboratory, 4041, Department of Hematology, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen O, Denmark.
    • ,
  • Tania Masmas

      Affiliations

    • The Allogeneic Hematopoietic Cell Transplantation Laboratory, Department of Hematology, Rigshospitalet, University of Copenhagen, Denmark
    • ,
  • Søren L. Petersen

      Affiliations

    • The Allogeneic Hematopoietic Cell Transplantation Laboratory, Department of Hematology, Rigshospitalet, University of Copenhagen, Denmark
    • ,
  • Hans O. Madsen

      Affiliations

    • Laboratory of Molecular Medicine, Department of Clinical Immunology University of Copenhagen, Denmark
    • ,
  • Carsten Heilmann

      Affiliations

    • Pediatric Clinic II, Rigshospitalet, University of Copenhagen, Denmark
    • ,
  • Lone Schejbel

      Affiliations

    • Laboratory of Molecular Medicine, Department of Clinical Immunology University of Copenhagen, Denmark
    • ,
  • Henrik Sengeløv

      Affiliations

    • The Bone Marrow Transplantation Unit, Department of Hematology, Rigshospitalet, University of Copenhagen, Denmark
    • ,
  • Klaus Müller

      Affiliations

    • Pediatric Clinic II, Rigshospitalet, University of Copenhagen, Denmark
    • ,
  • Peter Garred

      Affiliations

    • Laboratory of Molecular Medicine, Department of Clinical Immunology University of Copenhagen, Denmark
    • ,
  • Lars Vindeløv

      Affiliations

    • The Allogeneic Hematopoietic Cell Transplantation Laboratory, Department of Hematology, Rigshospitalet, University of Copenhagen, Denmark
    • The Bone Marrow Transplantation Unit, Department of Hematology, Rigshospitalet, University of Copenhagen, Denmark

Received 21 July 2009 ,Accepted 3 October 2009.

  • Image Result

    Schematic illustration of the high mobility group box 1 protein gene locus with exon I to V, marked as solid boxes, and the approximate location of the genetic variants. The most common inferred haplo

    Schematic illustration of the high mobility group box 1 protein gene locus with exon I to V, marked as solid boxes, and the approximate location of the genetic variants. The most common inferred haplotypes (frequency >3%), called H1 to H4, in patients and donors are shown. Modified from Ferrari et al. [37].

  • Image Result
    Cumulative incidence of relapse incidence and relapse related mortality according to patient −1377delA genotype in the transplantation cohort treated with myeloablative conditioning. Gray's k-test bet

    Cumulative incidence of relapse incidence and relapse related mortality according to patient −1377delA genotype in the transplantation cohort treated with myeloablative conditioning. Gray's k-test between patients with A/A genotype versus patients with A/− or −/− genotypes.

  • Image Result
    Cumulative incidence of OS, PFS, RI, and RRM according to patient 3814C > G genotype in the transplantation cohort treated with myeloablative conditioning. Gray's k-test between patients with G/G geno

    Cumulative incidence of OS, PFS, RI, and RRM according to patient 3814C > G genotype in the transplantation cohort treated with myeloablative conditioning. Gray's k-test between patients with G/G genotype versus patients with C/G or C/C genotype.

  • Image Result
    Cumulative incidence of limited or extensive cGVHD, according to donor 2351insT genotype in the transplantation cohort treated with myeloablative conditioning.

    Cumulative incidence of limited or extensive cGVHD, according to donor 2351insT genotype in the transplantation cohort treated with myeloablative conditioning.

 Financial disclosure: See Acknowledgments on page 250.

PII: S1083-8791(09)00458-3

doi: 10.1016/j.bbmt.2009.10.002

Biology of Blood and Marrow Transplantation
Volume 16, Issue 2 , Pages 239-252 , February 2010

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