Biology of Blood and Marrow Transplantation
Volume 16, Issue 1, Supplement , Pages S75-S81 , January 2010

Immunotherapy for Pediatric Central Nervous System Tumors

  • Sharon L. Gardner

      Affiliations

    • Division of Pediatric Hematology/Oncology, Steven D. Hassenfeld Children's Center for Cancer and Blood Disorders, New York University, New York, New York
    • Corresponding Author InformationCorrespondence and reprint requests: Dr. Sharon L. Gardner, Steven D. Hassenfeld Children's Center for Cancer and Blood Disorders, 160 E. 32nd Street, 2nd Floor, New York, NY 10016.
    • ,
  • Nabil Ahmed

      Affiliations

    • Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas
    • ,
  • Hideho Okada

      Affiliations

    • Brain Tumor Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania

  • Image Result

    CARs consist of an extracellular antigen-recognition domain (ectodomain), a transmembrane domain, and an intracellular signaling domain (endodomain). A CAR with a CD3-ξ signaling domain is shown. Addi

    CARs consist of an extracellular antigen-recognition domain (ectodomain), a transmembrane domain, and an intracellular signaling domain (endodomain). A CAR with a CD3-ξ signaling domain is shown. Additional signaling domains derived from costimulatory molecules can be introduced into the endodomain to enhance CAR-mediated T cell activation.

 Financial disclosure: See Acknowledgments on page S79.

PII: S1083-8791(09)00520-5

doi: 10.1016/j.bbmt.2009.11.003

Biology of Blood and Marrow Transplantation
Volume 16, Issue 1, Supplement , Pages S75-S81 , January 2010

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