Low-Dose Total Body Irradiation and Fludarabine Conditioning for HLA Class I-Mismatched Donor Stem Cell Transplantation and Immunologic Recovery in Patients with Hematologic Malignancies: A Multicenter Trial

Cumulative incidences of grade II, III, and IV aGVHD (A) and clinical, extensive cGVHD (B).

Kaplan-Meier product estimates of NRM and relapse (A), overall survival and progression-free survival (B), and overall survival as stratified by HCT-CI score (C).

Recovery of lymphocyte subsets. Recovery of NK, B cells, dendritic cell precursors, CD4+ and CD8+ T cells after transplantation (A). Recovery of naive, memory/effector, CD28+ or CD28−, CD4+ and CD8+ T cells after transplantation (B). The y-axis shows the number of cells per microliter of blood. Patient medians (diamonds) and 25th-75th percentiles (error bars) are displayed. Normal medians (of 104 normal adults) are indicated by the dashed horizontal lines; the thick horizontal lines denote the normal 10th-90th percentiles. Pretransplantation studies are arbitrarily shown as performed using blood collected at 1-month pretransplantation, despite the fact that blood was drawn at any time between 1 month pretransplantation and the morning of starting conditioning. Day 0 studies were performed using blood drawn immediately before graft infusion. Nine patient blood samples were analyzed before transplantation, 7 were analyzed on day 0, 6 were analyzed at 1 month posttransplantation, 8 were analyzed at 3 months posttransplantation, 6 were analyzed at 6 months posttransplantation, and 5 were analyzed at 12 months posttransplantation.

Recovery of lymphocyte subsets. Recovery of NK, B cells, dendritic cell precursors, CD4+ and CD8+ T cells after transplantation (A). Recovery of naive, memory/effector, CD28+ or CD28−, CD4+ and CD8+ T cells after transplantation (B). The y-axis shows the number of cells per microliter of blood. Patient medians (diamonds) and 25th-75th percentiles (error bars) are displayed. Normal medians (of 104 normal adults) are indicated by the dashed horizontal lines; the thick horizontal lines denote the normal 10th-90th percentiles. Pretransplantation studies are arbitrarily shown as performed using blood collected at 1-month pretransplantation, despite the fact that blood was drawn at any time between 1 month pretransplantation and the morning of starting conditioning. Day 0 studies were performed using blood drawn immediately before graft infusion. Nine patient blood samples were analyzed before transplantation, 7 were analyzed on day 0, 6 were analyzed at 1 month posttransplantation, 8 were analyzed at 3 months posttransplantation, 6 were analyzed at 6 months posttransplantation, and 5 were analyzed at 12 months posttransplantation.