Biology of Blood and Marrow Transplantation
Volume 16, Issue 3 , Pages 395-402 , March 2010

Race and Outcomes of Autologous Hematopoietic Cell Transplantation for Multiple Myeloma

  • Parameswaran N. Hari

      Affiliations

    • Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin
    • Corresponding Author InformationCorrespondence and reprint requests: Parameswaran Hari, MD, MS, CIBMTR, Medical College of Wisconsin, P.O. Box 26509, 8701 Watertown Plank Road, Milwaukee, WI 53226.
    • ,
  • Navneet S. Majhail

      Affiliations

    • Center for International Blood and Marrow Transplant Research, National Marrow Donor Program, Minneapolis, Minnesota
    • University of Minnesota, Minneapolis Minnesota
    • ,
  • Mei-Jie Zhang

      Affiliations

    • Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin
    • ,
  • Anna Hassebroek

      Affiliations

    • Center for International Blood and Marrow Transplant Research, National Marrow Donor Program, Minneapolis, Minnesota
    • ,
  • Fareeha Siddiqui

      Affiliations

    • Medical College of Wisconsin, Milwaukee, Wisconsin
    • ,
  • Karen Ballen

      Affiliations

    • Massachusetts General Hospital, Boston, Massachusetts
    • ,
  • Asad Bashey

      Affiliations

    • Blood and Marrow Transplant Group of Georgia, Atlanta, Georgia
    • ,
  • Jenny Bird

      Affiliations

    • Bristol Haematology and Oncology Centre, Bristol, United Kingdom
    • ,
  • Cesar O. Freytes

      Affiliations

    • South Texas Veterans Health Care System and University of Texas Health Center at San Antonio, San Antonio, Texas
    • ,
  • John Gibson

      Affiliations

    • Royal Prince Alfred Hospital, Camperdown, Australia
    • ,
  • Gregaory Hale

      Affiliations

    • A Children's Hospital, Saint Petersburg, Florida
    • ,
  • Leona Holmberg

      Affiliations

    • Fred Hutchinson Cancer Research Center, Seattle, Washington
    • ,
  • Ram Kamble

      Affiliations

    • Baylor College of Medicine, Houston, Texas
    • ,
  • Robert A. Kyle

      Affiliations

    • Mayo Clinic, Rochester Minnesota
    • ,
  • Hillard M. Lazarus

      Affiliations

    • University Hospitals Case Medical Center, Cleveland, Ohio
    • ,
  • Charles F. LeMaistre

      Affiliations

    • Texas Transplant Institute, San Antonio, Texas
    • ,
  • Fausto Loberiza

      Affiliations

    • University of Nebraska Medical Center, Omaha, Nebraska
    • ,
  • Angelo Maiolino

      Affiliations

    • Hospital Univarstario Clementino Frago Filho, Rio de Janeiro, Brazil
    • ,
  • Philip L. McCarthy

      Affiliations

    • Roswell Park Cancer Institute, Buffalo New York
    • ,
  • Gustavo Milone

      Affiliations

    • Angelica Ocampo-Hospital and Research Center, Fundaleu Buenos Aires, Argentina
    • ,
  • Nancy Omondi

      Affiliations

    • National Marrow Donor Program, Minneapolis, Minnesota
    • ,
  • Donna E. Reece

      Affiliations

    • University of Toronto, Toronto, Ontario, Canada
    • ,
  • Matthew Seftel

      Affiliations

    • CancerCare Manitoba, Manitoba, Canada
    • ,
  • Michael Trigg

      Affiliations

    • Merck & Co. Inc., Wilmington, Delaware
    • ,
  • David Vesole

      Affiliations

    • Loyola University Health System, Maywood, Illinois
    • ,
  • Brendan Weiss

      Affiliations

    • Walter Reed Army Medical Center, Washington, DC
    • ,
  • Peter Wiernik

      Affiliations

    • New York Medical College, Bronx, New York
    • ,
  • Stephanie J. Lee

      Affiliations

    • Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin
    • ,
  • J. Douglas Rizzo

      Affiliations

    • Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin
    • ,
  • Paulette Mehta

      Affiliations

    • University of Arkansas, Little Rock, Arkansas

Received 11 September 2009 ,Accepted 8 November 2009.

References 

  1. Kyle RA, Rajkumar SV. Epidemiology of the plasma-cell disorders. Best Pract Res Clin Haematol. 2007;20:637–664
  2. Kumar SK, Rajkumar SV, Dispenzieri A, et al. Improved survival in multiple myeloma and the impact of novel therapies. Blood. 2008;111:2516–2520
  3. Brown LM, Gridley G, Check D, Landgren O. Risk of multiple myeloma and monoclonal gammopathy of undetermined significance among white and black male United States veterans with prior autoimmune, infectious, inflammatory, and allergic disorders. Blood. 2008;111:3388–3394
  4. Landgren O, Gridley G, Turesson I, et al. Risk of monoclonal gammopathy of undetermined significance (MGUS) and subsequent multiple myeloma among black and white veterans in the United States. Blood. 2006;107:904–906
  5. Ries L, Melbert D, Krapcho M, et al. SEER Cancer Statistics Review, 1975-2005, National Cancer Institute. Bethesda, MD. http://seer.cancer.gov/csr/1975_2005, based on November 2007 SEER data submission, posted to the SEER web site, 2008. last accessed January 2009.
  6. Singh J, Dudley AW, Kulig KA. Increased incidence of monoclonal gammopathy of undetermined significance in blacks and its age-related differences with whites on the basis of a study of 397 men and one woman in a hospital setting. J Lab Clin Med. 1990;116:785–789
  7. Landgren O, Katzmann JA, Hsing AW, et al. Prevalence of monoclonal gammopathy of undetermined significance among men in Ghana. Mayo Clin Proc. 2007;82:1468–1473
  8. Samanic C, Gridley G, Chow WH, Lubin J, Hoover RN, Fraumeni JF. Obesity and cancer risk among white and black United States veterans. Cancer Causes Control. 2004;15:35–43
  9. Benjamin M, Reddy S, Brawley OW. Myeloma and race: a review of the literature. Cancer Metastasis Rev. 2003;22:87–93
  10. Friedman GD, Herrinton LJ. Obesity and multiple myeloma. Cancer Causes Control. 1994;5:479–483
  11. http://seer.cancer.gov/statfacts/html/mulmy.html. last accessed January 2009.
  12. Abou-Jawde RM, Baz R, Walker E, et al. The role of race, socioeconomic status, and distance traveled on the outcome of black patients with multiple myeloma. Haematologica. 2006;91:1410–1413
  13. Savage D, Lindenbaum J, Van Ryzin J, Struening E, Garrett TJ. Race, poverty, and survival in multiple myeloma. Cancer. 1984;54:3085–3094
  14. Cella DF, Orav EJ, Kornblith AB, et al. Socioeconomic status and cancer survival. J Clin Oncol. 1991;9:1500–1509
  15. Lyn D, Cherney BW, Lalande M, et al. A duplicated region is responsible for the poly(ADP-ribose) polymerase polymorphism, on chromosome 13, associated with a predisposition to cancer. Am J Hum Genet. 1993;52:124–134
  16. Cao J, Hong CH, Rosen L, et al. Deletion of genetic material from a poly(ADP-ribose) polymerase-like gene on chromosome 13 occurs frequently in patients with monoclonal gammopathies. Cancer Epidemiol Biomarkers Prev. 1995;4:759–763
  17. Attal M, Harousseau JL, Stoppa AM, et al. A prospective, randomized trial of autologous bone marrow transplantation and chemotherapy in multiple myeloma. Intergroupe Francais du Myelome. N Engl J Med. 1996;335:91–97
  18. Child JA, Morgan GJ, Davies FE, et al. High-dose chemotherapy with hematopoietic stem-cell rescue for multiple myeloma. N Engl J Med. 2003;348:1875–1883
  19. Joshua TV, Rizzo JD, Zhang MJ, Horowitz MM. Access to hematopoietic stem cell transplantation: effect of race and gender. Biol Blood Marrow Transplant. 2007;13(Suppl):22
  20. Blade J, Samson D, Reece D, et al. Criteria for evaluating disease response and progression in patients with multiple myeloma treated by high-dose therapy and haemopoietic stem cell transplantation. Myeloma Subcommittee of the EBMT. European Group for Blood and Marrow Transplant. Br J Haematol. 1998;102:1115–1123
  21. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc. 1958;53:457–481
  22. Klein JP, Moeschberger ML. Survival Analysis: Techniques for Censored and Truncated Data. 2nd ed.. New York: Springer Verlag; 2003;
  23. Cox DR. Regression models and life tables. J R Stat Soc B. 1972;34:187–220
  24. Saraf S, Chen YH, Dobogai LC, et al. Prolonged responses after autologous stem cell transplantation in black patients with multiple myeloma. Bone Marrow Transplant. 2006;37:1099–1102
  25. Rohatgi N, Du XL, Coker AL, Moye LA, Wang M, Fang S. Chemotherapy and survival for patients with multiple myeloma: findings from a large nationwide and population-based cohort. Am J Clin Oncol. 2007;30:540–548
  26. Modiano MR, Villar-Werstler P, Crowley J, Salmon SE. Evaluation of race as a prognostic factor in multiple myeloma. An ancillary of Southwest Oncology Group Study 8229. J Clin Oncol. 1996;14:974–977
  27. Verma PS, Howard RS, Weiss BM. The impact of race on outcomes of autologous transplantation in patients with multiple myeloma. Am J Hematol. 2008;83:355–358
  28. Khaled Y, Abidi MH, Janakiraman N, et al. Outcomes after auto-SCT in blacks with multiple myeloma. Bone Marrow Transplant. 2009;43:845–851
  29. Bach PB, Schrag D, Brawley OW, Galaznik A, Yakren S, Begg CB. Survival of blacks and whites after a cancer diagnosis. JAMA. 2002;287:2106–2113

 Financial disclosure: See Acknowledgments on page 401.

PII: S1083-8791(09)00524-2

doi: 10.1016/j.bbmt.2009.11.007

Biology of Blood and Marrow Transplantation
Volume 16, Issue 3 , Pages 395-402 , March 2010

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