Biology of Blood and Marrow Transplantation
Volume 16, Issue 3 , Pages 350-357 , March 2010

Early Elevation of C-Reactive Protein Correlates with Severe Infection and Nonrelapse Mortality in Children Undergoing Allogeneic Stem Cell Transplantation

  • Jennifer L. McNeer

      Affiliations

    • University of Chicago, Department of Pediatrics, Section of Hematology/Oncology, Chicago, Illinois
    • ,
  • Morris Kletzel

      Affiliations

    • Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Feinberg School of Medicine, Chicago, Illinois
    • Children's Memorial Hospital, Chicago, Illinois
    • ,
  • Alfred Rademaker

      Affiliations

    • Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Feinberg School of Medicine, Chicago, Illinois
    • ,
  • Kavita Alford

      Affiliations

    • Children's Memorial Hospital, Chicago, Illinois
    • ,
  • Kathleen O'Day

      Affiliations

    • University Medical Center at Princeton, Princeton, New Jersey
    • ,
  • Colleen Schaefer

      Affiliations

    • Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Feinberg School of Medicine, Chicago, Illinois
    • Children's Memorial Hospital, Chicago, Illinois
    • ,
  • Reggie Duerst

      Affiliations

    • Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Feinberg School of Medicine, Chicago, Illinois
    • Children's Memorial Hospital, Chicago, Illinois
    • ,
  • David A. Jacobsohn

      Affiliations

    • Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Feinberg School of Medicine, Chicago, Illinois
    • Children's Memorial Hospital, Chicago, Illinois
    • Corresponding Author InformationCorrespondence and reprint requests: David A. Jacobsohn, MD, Northwestern University School of Medicine, Stem Cell Transplant Program, Children's Memorial Hospital, 2300 Children's Plaza, Box #30, Chicago, IL 60614.

Received 16 September 2009 ,Accepted 20 October 2009.

  • Image Result

    Scatter plot with medians of maximum day 0-7 CRP by severe infection or NRM.

    Scatter plot with medians of maximum day 0-7 CRP by severe infection or NRM.

  • Image Result

    (A) ROC curve for the outcome of severe infection. The AUC is 0.742. The arrow indicates a CRP of 4.35 mg/dL, which corresponds to a sensitivity of 70% and specificity of 72% for severe infection. (B)

    (A) ROC curve for the outcome of severe infection. The AUC is 0.742. The arrow indicates a CRP of 4.35 mg/dL, which corresponds to a sensitivity of 70% and specificity of 72% for severe infection. (B) ROC curve for the outcome of NRM. The AUC is 0.742. The arrow indicates a CRP of 7.05 mg/dL, which corresponds to a sensitivity of 72% and specificity of 78% for NRM.

  • Image Result
    Cumulative incidence of NRM according to maximum CRP during days 0-7 of HSCT.

    Cumulative incidence of NRM according to maximum CRP during days 0-7 of HSCT.

 Financial disclosure: See Acknowledgments on page 356.

PII: S1083-8791(09)00589-8

doi: 10.1016/j.bbmt.2009.10.036

Biology of Blood and Marrow Transplantation
Volume 16, Issue 3 , Pages 350-357 , March 2010

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