Biology of Blood and Marrow Transplantation
Volume 16, Issue 7 , Pages 1005-1017 , July 2010

Defibrotide for the Treatment of Severe Hepatic Veno-Occlusive Disease and Multiorgan Failure after Stem Cell Transplantation: A Multicenter, Randomized, Dose-Finding Trial

  • Paul G. Richardson

      Affiliations

    • Department of Adult Oncology, Center for Hematologic Oncology, Dana-Farber Cancer Institute, Beth Israel Deaconess Medical Center, Massachusetts General Hospital; Children's Hospital, and Harvard Medical School, Boston, Massachusetts
    • Corresponding Author InformationCorrespondence and reprint requests: Paul G. Richardson, MD, Dana-Farber Cancer Institute, 44 Binney Street, Dana 1B02, Boston, MA 02115.
    • ,
  • Robert J. Soiffer

      Affiliations

    • Department of Adult Oncology, Center for Hematologic Oncology, Dana-Farber Cancer Institute, Beth Israel Deaconess Medical Center, Massachusetts General Hospital; Children's Hospital, and Harvard Medical School, Boston, Massachusetts
    • ,
  • Joseph H. Antin

      Affiliations

    • Department of Adult Oncology, Center for Hematologic Oncology, Dana-Farber Cancer Institute, Beth Israel Deaconess Medical Center, Massachusetts General Hospital; Children's Hospital, and Harvard Medical School, Boston, Massachusetts
    • ,
  • Hajime Uno

      Affiliations

    • Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts
    • ,
  • Zhezhen Jin

      Affiliations

    • Department of Biostatistics, Columbia University, New York, New York
    • ,
  • Joanne Kurtzberg

      Affiliations

    • Duke University Medical Center, Durham, North Carolina
    • ,
  • Paul L. Martin

      Affiliations

    • Duke University Medical Center, Durham, North Carolina
    • ,
  • Gideon Steinbach

      Affiliations

    • Fred Hutchinson Cancer Research Center, Seattle, Washington
    • ,
  • Karen F. Murray

      Affiliations

    • Seattle Children's Hospital, Seattle, Washington
    • ,
  • Georgia B. Vogelsang

      Affiliations

    • Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland
    • ,
  • Allen R. Chen

      Affiliations

    • Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland
    • ,
  • Amrita Krishnan

      Affiliations

    • City of Hope Cancer Center, Duarte, California
    • ,
  • Nancy A. Kernan

      Affiliations

    • Memorial Sloan-Kettering Cancer Center, New York, New York
    • ,
  • David E. Avigan

      Affiliations

    • Department of Adult Oncology, Center for Hematologic Oncology, Dana-Farber Cancer Institute, Beth Israel Deaconess Medical Center, Massachusetts General Hospital; Children's Hospital, and Harvard Medical School, Boston, Massachusetts
    • ,
  • Thomas R. Spitzer

      Affiliations

    • Department of Adult Oncology, Center for Hematologic Oncology, Dana-Farber Cancer Institute, Beth Israel Deaconess Medical Center, Massachusetts General Hospital; Children's Hospital, and Harvard Medical School, Boston, Massachusetts
    • ,
  • Howard M. Shulman

      Affiliations

    • Fred Hutchinson Cancer Research Center, Seattle, Washington
    • ,
  • Donald N. Di Salvo

      Affiliations

    • Department of Radiology, Harvard Medical School, Dana-Farber Cancer Institute, and Brigham and Women's Hospital, Boston, Massachusetts
    • ,
  • Carolyn Revta

      Affiliations

    • Department of Adult Oncology, Center for Hematologic Oncology, Dana-Farber Cancer Institute, Beth Israel Deaconess Medical Center, Massachusetts General Hospital; Children's Hospital, and Harvard Medical School, Boston, Massachusetts
    • ,
  • Diane Warren

      Affiliations

    • Department of Adult Oncology, Center for Hematologic Oncology, Dana-Farber Cancer Institute, Beth Israel Deaconess Medical Center, Massachusetts General Hospital; Children's Hospital, and Harvard Medical School, Boston, Massachusetts
    • ,
  • Parisa Momtaz

      Affiliations

    • Department of Adult Oncology, Center for Hematologic Oncology, Dana-Farber Cancer Institute, Beth Israel Deaconess Medical Center, Massachusetts General Hospital; Children's Hospital, and Harvard Medical School, Boston, Massachusetts
    • ,
  • Gary Bradwin

      Affiliations

    • Department of Laboratory Medicine, Children's Hospital, Boston, Massachusetts
    • ,
  • L.J. Wei

      Affiliations

    • Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts
    • ,
  • Massimo Iacobelli

      Affiliations

    • Gentium SpA, Villa Guardia, Como, Italy
    • ,
  • George B. McDonald

      Affiliations

    • Fred Hutchinson Cancer Research Center, Seattle, Washington
    • ,
  • Eva C. Guinan

      Affiliations

    • Department of Pediatrics, Dana-Farber Cancer Institute and Division of Hematology/Oncology, Children's Hospital, Boston, Massachusetts

Received 28 October 2009 ,Accepted 9 February 2010.

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 Financial disclosure: See Acknowledgments, page 1016.

PII: S1083-8791(10)00065-0

doi: 10.1016/j.bbmt.2010.02.009

Biology of Blood and Marrow Transplantation
Volume 16, Issue 7 , Pages 1005-1017 , July 2010

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